Heterogeneity of immunoregulatory T-cell subsets in systemic lupus erythematosus

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In previous studies, we demonstrated that patients with active systemic lupus erythematosus (SLE) had significantly decreased percentages of circulating CD4+ 2H4+ suppressorlinducer cells. The decrease in this T cell subset was most frequent and most marked in patients with active SLE and renal disease. In the present study, we attempted to determine whether SLE patients had plasma antilymphocyte antibodies preferentially reactive with the CD4+2H4+ subset. We found that many SLE patients did have these specifically reactive antibodies. Furthermore, the presence of antilymphocyte antibodies reactive with CD4+2H4+ cells correlated with disease activity in these patients. Also, in vitro functional studies revealed that suppressorlinducer function was eliminated in the pokeweed mitogendriven IgG synthesis system after the treatment of CD4 cells with patient plasma antilymphocyte antibodies and complement. These results suggest that antilymphocyte antibodies play a role in the elimination of CD4+2H4+ cells in patients with active SLE.

Section: Discussionmentioning

confidence: 97%

Antilymphocyte antibodies against CD4+2H4+ cell populations in patients with systemic lupus erythematosus

Tanaka

Matsuyama

Steinberg

et al. 1989

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“…Nonetheless, protective effects of MO on renal disease, demonstrated histologically, were observed in all 3 strains. This suggests that marine lipid diets could be generally beneficial in humans who have systemic lupus erythematosus (SLE), even though different abnormalities in immunoregulation may be present in different patients with that syndrome (21).…”

Section: Discussionmentioning

confidence: 99%

Dietary fish oil reduces progression of established renal disease in (NZB × NZW)F₁ mice and delays renal disease in BXSB and MRL/1 strains

Robinson

Prickett

Makoul

et al. 1986

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126

Previous studies have shown that dietary marine lipids containing large quantities of n-3 polyunsaturated fatty acids, administered to (New Zealand black X New Zealand white)F1 and MRL-lpr/lpr mice before the development of renal disease, reduce the severity of glomerulonephritis in mice of these strains. The present stud,y demonstrated that delayed administration of a marine lipid diet, 25% menhaden oil (MO) by weight, until after the onset of overt renal disease, also resulted in significant improvement in rates of mortality, proteinuria, and histologic evidence of glomerular injury, compared with control animals fed a diet that contained mostly saturated fatty acids, 25% beef tallow. The MO diet also reduced the histologic severity of renal disease in male BXSB/MpJ and male MRL-lpr/lpr mice. In contrast, necrotizing vasculitis was more frequent in From the

“…Morimoto and coworkers have recently reported a selective decrease in OKT8+ cells (13). Smolen and associates were unable to confirm this finding and reported that a decrease in OKT4+ cell subsets was the most frequent abnormality (14).…”

mentioning

confidence: 96%

“…Although B cell function is increased, T cell functions which include delayed hypersensitivity (1-3, mitogenic reactivity (6,7), generation of antigen-specific reactivities (8), and development of nonspecific suppressor (14).…”

mentioning

confidence: 99%

T Lymphocyte Subsets in Systemic Lupus Erythematosus

Bakke

Kirkland

Kitridou

et al. 1983

The contribution of immune regulation to the etiology of systemic lupus erythematosus (SLE) is poorly understood. Using the monoclonal antibodies OKT4 and OKTS, we quantitated, by flow cytometry, T inducer/ helper and T cytotoxicfsuppressor cells in patients with SLE. Serologically active patients, who had clinical manifestations such as arthritis or rash and were not receiving prednisone, were characteristically lymphopenic due to a marked reduction in OKT4+ cells. Prednisone therapy produced the same phenomenon. Untreated patients, who were serologically inactive, demonstrated no abnormalities. These studies have thus revealed two presumably independent factors that can produce similar immunoregulatory aberrations.Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by excessive immunoglobulin and autoantibody production. Although B cell function is increased, T cell functions which include delayed hypersensitivity (1-3, mitogenic reactivity (6,7), generation of antigen-specific reactivities (8), and development of nonspecific suppressor (14).We studied 28 patients with SLE who were divided into groups based on corticosteroid therapy and serologic evidence of disease activity. We will describe clinically significant abnormalities in the absolute number and relative proportions of immunoregulatory T cell subsets based upon this classification. PATIENTS AND METHODSPatients. This study included 28 patients (24 females, 4 males) with SLE according to the American Rheumatism Association ( M A ) preliminary criteria (15). Two to 3 patients were randomly selected in the lupus clinic visits each month from April 1981 to April 1982. These patients were then separated into 2 groups based on existing therapy, one receiving more than 10 mg prednisone per day, the other receiving 10 mg or less of prednisone per day. A special attempt was made to isolate newly diagnosed lupus patients being treated with 10 mg or less prednisone per day. During this 1-year period, 11 newly diagnosed patients were seen, but only 6 had 4 or more ARA preliminary criteria; of these 6, only 5 were treated with less than 10 mg prednisone per day.Control groups consisted of 16 women and 5 men with scleroderma and 16 patients with lepromatous leprosy. They will be described in detail elsewhere. Normal individ-