Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils

Decot, Véronique; Woerly, G.; Loyens, Marc; Loiseau, Sylvie; Quatannens, Brigitte; Capron, Moníque; Dombrowicz, David

doi:10.4049/jimmunol.174.2.628

Cited by 39 publications

(21 citation statements)

References 43 publications

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“…However, because of the strong disparity between human and mouse eosinophils (8,38), those results were not totally relevant to clinical situations. Several studies attempted to assess the prognostic value of TATE to support, even indirectly, the tumoricidal properties of eosinophils and the benefit that they might provide to patients.…”

Section: Discussionmentioning

confidence: 98%

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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Eosinophils are multifunctional leukocytes that are involved in innate and adaptive immune responses through the expression of various receptors and mediators. Previously, we showed that human eosinophils and T cells shared cytotoxic activities against tumor cells that involved the γ-δ TCR and cell–cell contact. In this study, we investigated the molecules involved in eosinophil–tumor cell interactions. Given the role of IL-18 in cell adhesion and in protecting against colon cancer, we evaluated its role in eosinophil-mediated cytotoxicity against Colo-205, a human colon carcinoma cell line. We found that human eosinophils exerted dose- and time-dependent tumoricidal activity against Colo-205 cells. Neutralization of IL-18 significantly reduced eosinophil-mediated Colo-205 apoptosis and inhibited cell–cell adhesion. Moreover, addition of rIL-18 led to upregulation of CD11a and ICAM-1 adhesion molecules, which were involved in the contact between eosinophils and Colo-205 cells. Our results indicated that IL-18 was involved in the eosinophil-mediated death of Colo-205 by facilitating contact between effector and target cells. These data underscored the involvement of an additional mediator in eosinophil-mediated antitumor cytotoxicity. Our findings support existing evidence that eosinophils could play a beneficial role in the context of colon cancer.

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Section: Discussionmentioning

confidence: 98%

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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“…There are substantial differences in IgA-mediated immunity between mice and humans regarding the IgA receptors that they express (8). Although IgA was not required to clear B. pertussis and B. parapertussis in the mouse model, this isotype may be important in humans.…”

Section: Discussionmentioning

confidence: 99%

Comparative Role of Immunoglobulin A in Protective Immunity against the Bordetellae

Wolfe¹,

Kirimanjeswara²,

Goebel

et al. 2007

Infect Immun

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The genus Bordetella includes a group of closely related mammalian pathogens that cause a variety of respiratory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans (B. pertussis and B. parapertussis). While past research has examined how these pathogens are eliminated from the lower respiratory tract, the host factors that control and/or clear the bordetellae from the upper respiratory tract remain unclear. We hypothesized that immunoglobulin A (IgA), the predominant mucosal antibody isotype, would have a protective role against these mucosal pathogens. IgA ؊/؊ mice were indistinguishable from wild-type mice in their control and clearance of B. pertussis or B. parapertussis, suggesting that IgA is not crucial to immunity to these organisms. However, naïve and convalescent IgA ؊/؊ mice were defective in reducing the numbers of B. bronchiseptica in the upper respiratory tract compared to wild-type controls. Passively transferred serum from convalescent IgA ؊/؊ mice was not as effective as serum from convalescent wild-type mice in clearing this pathogen from the tracheae of naive recipient mice. IgA induced by B. bronchiseptica infection predominantly recognized lipopolysaccharide-containing O-antigen, and antibodies against O-antigen were important to bacterial clearance from the trachea. Since an IgA response contributes to the control of B.

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“…sIgA is the most abundant class of antibodies at mucosal surfaces where eosinophils carry out many of their effector functions [32,33]. Thus, future studies with recombinant, antigen-specific sIgA will provide more insights into the roles of sIgA in eosinophil activation in mucosal tissues.…”

Section: Discussionmentioning

confidence: 99%

Antigen-Specific IgG and IgA, but Not IgE, Activate the Effector Functions of Eosinophils in the Presence of Antigen

Muraki

Gleich

Kita

2010

Int Arch Allergy Immunol

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Background: Activated eosinophils are thought to play an important role in allergic inflammation. Prior reports suggest that eosinophils have receptors recognizing IgA, IgG and IgE; however, little is known regarding the direct effects of antigens and antigen-specific immunoglobulins on the functions of eosinophils. Methods: To investigate eosinophil activation by antigens mediated by the various antigen-specific immunoglobulins, we used dansyl-conjugated bovine serum albumin (DNS-BSA) and recombinant dansyl-specific antibodies (human IgG 1–4, IgA and IgE). Eosinophils from healthy donors were incubated in the wells coated with dansyl-specific immunoglobulins with or without DNS-BSA. Eosinophil activation was monitored by superoxide production and eosinophil-derived neurotoxin (EDN) release. Results: Superoxide production and EDN release by eosinophils were induced by the dansyl-specific reaction via all IgG subclasses (IgG 1–4) and IgA in the presence of DNS-BSA; the responses were not observed in the absence of antigen, DNS-BSA. The immune complexes (ICs) of DNS-BSA and dansyl-specific IgE did not induce these responses. Furthermore, IgE ICs did not enhance eosinophil activation stimulated with various immunoglobulins, IL-5 or platelet-activating factor. Conclusion: These data suggest that ICs of antigens and antigen-specific IgGs and IgA, but not IgE, in inflamed tissues may activate eosinophils and play an important role in allergic inflammation.

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Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils

Cited by 39 publications

References 43 publications

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Comparative Role of Immunoglobulin A in Protective Immunity against the Bordetellae

Antigen-Specific IgG and IgA, but Not IgE, Activate the Effector Functions of Eosinophils in the Presence of Antigen

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