Heterogeneity of dermal OKT6+ cells in inflammatory and neoplastic skin diseases

Berti, Emilio; Cavicchini, S.; Cusini, Marco; Monti, M.; Parolini, F; Caputo, Ruggero

doi:10.1016/s0190-9622(85)70071-0

Cited by 13 publications

(3 citation statements)

References 28 publications

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“…A T6 positive cell population of Langerhans and indeterminate cells was seen in the dermis. Earlier studies have shown T6+ cells in normal dermis (Murphy et al, 1983) and increased numbers of T6+ cells in the allergic patch test reactions (Ralflciaer&Wantzin, 1984^ Berti c;a/., 1985) and other delayed-type responses (Konttinen et al, 1983) including natural lesions in atopic eczema (Leung et al, 1983;Zachary et al, 1985).…”

Section: Discussionmentioning

confidence: 96%

Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens

et al. 1986

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To determine whether inhalant allergens could induce eczematous lesions we studied 17 patients with atopic eczema (with or without allergic rhinitis), 13 patients with allergic rhinitis without atopic eczema and 10 healthy control subjects. The allergens, birch pollen (Betula verrucosa) and house dust mite (Dermatophagoides pteronyssinus), were applied in aluminium chambers for 48 h on clinically normal skin. In 17 patients with atopic eczema, six epicutaneous test reactions of the delayed type to birch pollen and three to house dust mite were seen at 48 or 72 h. In 13 patients with allergic rhinitis without eczema there was one delayed reaction to birch pollen and none to house dust mite. No delayed type test reactions to either allergen were seen in the controls. Biopsies of the positive test sites revealed an eczematous reaction with epidermal spongiosis and microvesiculation. Immunostaining of cryostat sections showed dermal cell infiltrates consisting of mainly T lymphocytes (ratio of T4:T8, 2-6:I) and to a lesser degree Langerhans and indeterminate T6+ cells. 50-90% of the cells were Ia+. The numbers of basophils and mast cells did not exceed 10-15%.

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Section: Discussionmentioning

confidence: 96%

Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens

et al. 1986

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“…A sitnilar phenominon is noted in many other cutaneous reactive processes. Furthermore, 90-95% of the dermal OKT-6-positive cells in contact dermatitis (13) were found to lack Birbeck granules. Thus, in immunomediated inflammatory lesions, many of these indeterminate cells appear to play a role in antigen processing.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, however, some histiocytic cells were S-100 positive and OKT-6 positive but laeked Birbeck gratiules. Therefore, they are considered to be indeterminate cells or Langerhans cell precursors (13).…”

Section: Discussionmentioning

confidence: 99%

Generalized eruptive histiocytoma: a report of a variant case showing the presence of dermal indeterminate cells

et al. 1991

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We describe a 14-year-old Japanese girl with a variant of generalized eruptive histiocytoma. She presented with the characteristic features of classical generalized eruptive histiocytoma but with the following minor differences. Clinically, some of the papular eruptions tended to coalesce to form plaques. Histoligically, some of the histiocytic cells were S-100 protein- and OKT-6-positive; these were thought to be indeterminate cells because they lacked Birbeck granules. In addition, PAS-positive cells were few and there were some intermingled lymphocytes and a few eosinophils.

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Congenital self-healing histiocytosis (Hashimoto-Pritzker): An ultrastructural and immunohistochemical study

Kanitakis

Zambruno

Schmitt

et al. 1988

Cancer

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Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cells were found to bear the immunohistochemical phenotype of normal epidermal Langerhans cells (LC) and histiocytosis X (HX) cells (CD1a/c+, CD1b-, CD4+/-, human leukocyte antigen [HLA]-DR/DQ+, S-100+). However, an electron microscope showed a paucity of Birbeck granule (BG)-containing cells. This contrasted with their immunophenotype. This finding, along with other ultrastructural characteristics of CSHH cells, suggests that histologic differences exist between CSHH and HX. However, because no absolute histologic criterion is known that allows unequivocally the differential diagnosis between the two diseases, this distinction currently has to rely on clinical criteria, mainly the regressive course observed within a few months in CSHH. The precise nosologic position of CSHH among other histiocytic syndromes remains unsettled.

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Heterogeneity of dermal OKT6+ cells in inflammatory and neoplastic skin diseases

Cited by 13 publications

References 28 publications

Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens

Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens

Generalized eruptive histiocytoma: a report of a variant case showing the presence of dermal indeterminate cells

Congenital self-healing histiocytosis (Hashimoto-Pritzker): An ultrastructural and immunohistochemical study

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