Heterogeneity of cockroach allergen-specific T cell responses in allergic sensitized children
Ricardo da Silva Antunes,
Aaron Sutherland,
April Frazier
et al.
Abstract:BACKGROUND: Characterization of allergic responses to cockroach (CR), a
common aeroallergen associated with asthma, has focused mainly on IgE
reactivity, but little is known about T cell responses, particularly in
children. We conducted a functional evaluation of CR allergen-specific T
cell reactivity in a cohort of CR allergic children with asthma.
METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from
71 children, with mild-to-moderate asthma who were enrolled in a CR
immunotherapy (IT) clini… Show more
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