Heterogeneity of circulating calcitonin levels: relations with calcitonin biosynthesis in medullary thyroid carcinomas

Guliana, J. M.; Taboulet, J.; Calmettes, C; Milhaud, G; Moukhtar, M.S.; Jullienne, A.

doi:10.1016/0969-8051(94)90059-0

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…It was assumed that secreted monomeric CT forms polymeric molecules or binds to other proteins in the peripheral blood [1,19]. This phenomenon is one reason for the existence of high molecular-weight forms of CT in the peripheral blood of patients suffering from MTC [19].…”

Section: Discussionmentioning

confidence: 99%

Calcitonin kinetics in the early postoperative period of medullary thyroid carcinoma

Brauckhoff

Gimm

Brauckhoff

et al. 2001

Langenbeck's Arch Surg

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Using a highly sensitive calcitonin assay, we demonstrated that normalisation of basal calcitonin levels may be delayed in patients suffering from medullary thyroid carcinoma. The lack of correlation of preoperative levels and the time to normalisation of the basal calcitonin levels, as well as the positive pentagastrin test in some of the patients, argues that this phenomenon is not simply due to prolonged biochemical calcitonin elimination. Nevertheless, a prognostic influence could not be shown in this study due to the short follow up-period. Further investigations and a longer follow-up are necessary to determine the nature and the prognostic impact of delayed normalisation of calcitonin levels.

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Section: Discussionmentioning

confidence: 99%

Calcitonin kinetics in the early postoperative period of medullary thyroid carcinoma

Brauckhoff

Gimm

Brauckhoff

et al. 2001

Langenbeck's Arch Surg

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show abstract

“…It has been assumed that secreted monomeric calcitonin forms polymeric molecules or binds to other proteins in the peripheral blood [27, 28]. This phenomenon is one reason for the existence of high molecular‐weight forms of calcitonin in the peripheral blood of MTC patients [28]. However, whether these high molecular weight or bonded forms have a longer half‐life based on a higher stability is not known [29].…”

Section: Discussionmentioning

confidence: 99%

“…The reason for the inadequate IO‐CT decrease in more of 20 % of the patients (5 of 23) who had undetectable serum calcitonin levels, should be sought in the different half‐lives of the serum calcitonin [26], which are probably related to the well‐known existence of polymeric forms of serum calcitonin [27, 28]. It has been assumed that secreted monomeric calcitonin forms polymeric molecules or binds to other proteins in the peripheral blood [27, 28]. This phenomenon is one reason for the existence of high molecular‐weight forms of calcitonin in the peripheral blood of MTC patients [28].…”

Section: Discussionmentioning

confidence: 99%