Heterogeneity of chronic lung allograft dysfunction: Insights from protein expression in broncho alveolar lavage

Survival Determinants in Lung Transplant Patients With Chronic Allograft Dysfunction

“…In our patient group, transbronchial biopsies did not specifically contribute to the differential diagnosis between BOS and RAS, as they were mostly nonspecific and were rather used to exclude acute rejection and infection. Also, BAL cell differentiation was not different between these two phenotypes, whereas for instance in the BOS subphenotypes, NRAD, and fybrotic bronchiolitis obliterans syndrome, this is indeed clearly different (3,10).…”

Differential Cytokine, Chemokine and Growth Factor Expression in Phenotypes of Chronic Lung Allograft Dysfunction

“…Similar to our previous study, we could confirm that in non-neutrophilic BOS patients, there is no mediator that is differentially expressed compared to stable patients. 4 As such, BAL does not seem to be the appropriate tool to study the mechanism of non-neutrophilic BOS. It seems more appropriate to rather study tissue for differential protein expressions in this particular condition.…”

State of Art: Clinical ex vivo lung perfusion: Rationale, current status, and future directions

“…65 The same group 66 and others 67 later reported that EVLP could be a valuable technique in finding those lungs within the donor pool that exhibited mildly inferior oxygenation but were still acceptable for transplant. These positive results stimulated several investigators to use animal models to identify therapies that could be used to recondition lungs before implantation.…”