Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease

Abstract

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Training‐induced changes on quadriceps muscle oxygenation measured by near‐infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients

“…Our results are also fully consistent with previously reported data (Boushel et al, 2001) showing training-induced increase in muscle O 2 extraction ratio without changes in lower limb blood flow at submaximal exercise (Louvaris et al, 2017). In the study by Sala et al (Sala et al, 1999), training increased lower limb blood flow at peak exercise both in COPD patients and in healthy sedentary subjects.…”

“…It is well accepted that skeletal muscle de‐oxygenation during CWRE represents the dynamic balance between muscle O 2 delivery/O 2 uptake at the level of the NIRS sensor placement. The current study demonstrates that endurance training further amplifies pretraining StO 2 fall during CWRE, both in healthy subjects and in COPD patients, without relevant changes in muscle blood volume (Louvaris et al ., ).…”

“…Our results are also fully consistent with previously reported data (Boushel et al ., ) showing training‐induced increase in muscle O 2 extraction ratio without changes in lower limb blood flow at submaximal exercise (Louvaris et al ., ). In the study by Sala et al .…”

“…Near-infrared spectroscopy (NIRS) emerged as an non-invasive method to evaluate oxidative capacity and blood flow and metabolism on skeletal muscle in patients with COPD (Adami et al, 2017;Louvaris et al, 2017). Previously, an early study described the potential applicability of NIRS during exercise training programmes (Puente-Maestu et al, 2003).…”

Non-Invasive Ventilation as an Adjunct to Exercise Training in Chronic Ventilatory Failure: A Narrative Review

“…Muscle blood flow and metabolic demand are matched in patients with COPD at submaximal exercise [37]. However, when WOB increases with increasing exercise intensity, blood flow may switch from the limbs to the respiratory muscles, leading to earlier peripheral muscle fatigue.…”