Heterogeneity in Subcutaneous Adipose Tissue Morphology and Metabolic Complications in Overweight and Obese Women

Vargas, Gracie; Chandalia, Manisha; Jiang, Yongquan; Davila, Himara; Abate, Nicola

doi:10.1089/met.2013.0024

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Many reports have shown a negative association between SC FCS and adiponectin release 19,61,69,103,105,106 , even after adjustment for SC adipose tissue area 19 . One study reported no association between OM FCS or SC FCS and adiponectin levels 24 .…”

Section: Adiponectin and Leptinmentioning

confidence: 99%

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

Laforest¹,

Labrecque²,

Michaud³

et al. 2015

Critical Reviews in Clinical Laboratory Sciences

174

148

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Obesity is a heterogeneous disease and is associated with comorbidities such as type 2 diabetes mellitus, cardiovascular disease and cancer. Several studies have examined the role of dysfunctional adipose tissue in the pathogenesis of obesity, highlighting the contrasting properties and impact of distinct fat compartments, sometimes with contradictory results. Dysfunctional adipose tissue involves enlargement, or hypertrophy, of pre-existing fat cells, which is thought to confer increases in cardiometabolic risk, independent of the level of obesity per se. In this article, we critically analyze available literature that examined the ability of adipocyte cell size to predict metabolic disease and adipose tissue dysfunction in humans. Many studies demonstrate that increased fat cell size is a significant predictor of altered blood lipid profiles and glucose-insulin homeostasis independent of adiposity indices. The contribution of visceral adiposity to these associations appears to be of particular importance. However, available studies are not unanimous and many fat depot-specific aspects of the relationship between increased fat cell size and cardiometabolic risk or parameters of adipose tissue dysfunction are still unresolved. Methodological factors such as the approach used to express the data may represent significant confounders in these studies. Additional studies should consider the fact that the relationship between fat cell size and common adiposity indices is non-linear, particularly when reaching the obese range. In conclusion, our analysis demonstrates that fat cell size is a significant predictor of the cardiometabolic alterations related to obesity. We propose that adipocyte hypertrophy, especially in the visceral fat compartment, may represent a strong marker of limited hyperplasic capacity in subcutaneous adipose tissues, which in turn is associated with the presence of numerous cardiometabolic alterations.

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Section: Adiponectin and Leptinmentioning

confidence: 99%

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

Laforest¹,

Labrecque²,

Michaud³

et al. 2015

Critical Reviews in Clinical Laboratory Sciences

174

148

View full text Add to dashboard Cite

show abstract

“…Adipocyte cell size correlates positively with secretion of proinflammatory adipocytokines, e.g., leptin, inteleukin 6 and 8 (IL-6, IL-8), and monocyte chemoattractant protein-1 (MCP-1), as shown by data from cultured adipocytes [ 81 ]. In humans, visceral adipocyte size correlates directly with leptin [ 45 ] and inversely with adiponectin [ 82 ]. Adipose tissue expansion is regulated by storage-related genes like DGAT2, SREBP1c and cell death activator (CIDEA).…”

Section: Dysfunctional Adipose Tissue: Accumulation and Remodelingmentioning

confidence: 99%

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

et al. 2015

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Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease.

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“… 64 Furthermore, the fraction of DPP4+ fibroblasts (FAC3) 56 , 57 , 58 is increased with AT hypertrophy, which supports the finding that adipocyte hypertrophy is associated with the thickening of pericellular collagen. 101 In addition, trajectory inference and RNA velocity analyses also revealed that FAC2 fibroadipogenic progenitors in AT hypertrophy are predicted to become FAC fibroblasts instead of FAC1 preadipocytes in AT hyperplasia, thus highlighting the potential role of FAC2 programming in mature adipocyte morphology and AT fibrosis. Because increased pericellular collagen deposition may hinder adipocyte expansion, increased number of fibroblasts may also contribute to ectopic fat accumulation and insulin resistance by limiting further fat storage expansion in hypertrophied subcutaneous adipocytes.…”

Section: Discussionmentioning

confidence: 94%

Adipocyte hypertrophy associates with in vivo postprandial fatty acid metabolism and adipose single-cell transcriptional dynamics

Ye,

Montastier,

Frisch

et al. 2024

iScience

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Heterogeneity in Subcutaneous Adipose Tissue Morphology and Metabolic Complications in Overweight and Obese Women

Abstract: In overweight/obese premenopausal women, larger adipocyte diameter in s.c. abdominal, but not gluteal, AT associates with low plasma adiponectin and systemic insulin resistance, and suggests that increased collagen thickness (obesity-related scarring) could contribute to these findings.

Cited by 6 publications

References 21 publications

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

Adipocyte hypertrophy associates with in vivo postprandial fatty acid metabolism and adipose single-cell transcriptional dynamics

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