Heterogeneity in presentation of hyperglycaemia during COVID-19 pandemic: A proposed classification

Exacerbation of hyperglycemia in patients with type 2 diabetes after vaccination for COVID19: Report of three cases

“…Fortunately, in all cases hyperglycemia was self-limiting, not requiring major changes in treatment, further strengthening transient immuno-inflammation as the cause. In difference to this, case of hyperosmolar hyperglycemic state after vaccination as described by Abu-Rumaileh et al [ 3 ] may be due to several factors including damage to beta cells as previously described [ 4 ].…”

Diabetes and COVID19: a bidirectional relationship

“…A global registry has now been established to study the link between COVID19 and new-onset diabetes [ 24 ]. Misra et al [ 25 ] have recently attempted to broadly classify new-onset hyperglycemia during the COVID pandemic into those with documented COVID19 infection and those without. Among individuals with documented COVID19 infection, more severe hyperglycemia was found in those with severe infection, probably due to a combination of factors such as cytokine storm, corticosteroid use, and direct beta-cell damage.…”

“…They found that individuals with new-onset diabetes during the COVID pandemic had higher fasting and postprandial glucose levels and glycated hemoglobin compared to those diagnosed before the pandemic, even though the two groups did not differ significantly in any other respect including exposure to COVID (as measured by SARS-CoV2 antibody levels). Interestingly, based on data from multiple studies, Misra et al [ 25 ] have stated that individuals without COVID19 infection who were diagnosed with either type 1 or type 2 diabetes during the pandemic, tended to present with more severe hyperglycemia than was the case prior to the pandemic (with a higher frequency of DKA in those presenting with type 1 diabetes). The worse metabolic profile of new-onset diabetes during the COVID pandemic is probably a reflection of increased stress, reduced physical activity and access to healthy foods and delayed diagnosis due to reluctance to visit physicians and hospitals during the pandemic and subsequent lockdown.…”

Majorly Resurgent and Uncontrolled Diabetes During COVID19 Era, and in the Future Can Be Contained in India

“…In previously published research and reviews related to COVID19 and diabetes, we and others had emphasised various ways that COVID19 can cause de novo hyperglycemia or exacerbate it in patients with diabetes ( 1 , 2 , 3 ). Several factors are responsible for it; systemic stress, effects of cytokine storm, enhanced PKA signalling, direct damage to beta cells by SARS-CoV2, and use of corticosteroids.…”