Heterogeneity in Malignant Soft Tissue Tumors

Kosmehl, Hartwig

doi:10.1007/978-3-642-77289-4_7

Cited by 4 publications

(1 citation statement)

References 160 publications

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“…São identificadas mais de 20 proteínas, dividas em tipo I (relativamente ácido, K9-K20) e tipo II (relativamente básica, kl-K8) (Fuchs & Weber, 1994). O anticorpo anti-AE1/AE3 reconhece proteínas do tipo I e do tipo II, sendo considerado como específico para identificação de diferenciação celular epitelial, sendo, desse modo, útil para a diferenciação de sarcomas e tumores malígnos de origem epitelial (Katenkamp & Kosmehl, 1995). Em RMSs a marcação para AE1/AE3 foi descrita variando entre O e 14,9% (Coindre et al, 1988;Folpe et ai., 2002;Hicks & Flaitz, 2002).…”

Section: Análise Imunohistoquímicaunclassified

Analises clinica, histopatologica e imunohistoquimica de rabdomiossarcomas da região de cabeça e pescoço

Andrade¹,

Lopes²

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Rhabdomyosarcoma is the most common soft tissue malignant tumor arising in children and young adults and it is rare in people older than 45 years. Many studies o f this tumor have been providing improvement of the prognosis. However, importance of the immunohistochemical expression of some proteins needs to be clarified. Therefore, the objectives o f this study were to analyze the clinicopathological and immunohistochemical features o f head and neck rhabdomyosarcomas and its relationship with the prognosis o f the patients. From 1954 to 2002, twenty-nine patients with head and neck rhabdomyosarcoma treated in the Department of Head and Neck Surgery and Otorhinolaryngology, CancerHospital AC Camargo, Sao Paulo, Brazil, were selected for this study. Clinicai data were obtained from the medicai records, and the histological slides were reviewed and the tumors were classified according to Enzinger and Weiss (2001). Immunohistochemical analysis was performed using primary antibodies anti vimentin, desmin, myogenin, MyoD1 and AE1/AE3 for diagnostic and p53, PCNA, Ki67, C-erbB2, FAS and CDK4 for prognostic significance by immunoperoxidase technique. The tumors were more frequent in the first two decades of life (mean age of 14.3 years) with a discreet male predilection (58.6%). The extraoral region was the most common location (62.1%) with prevalence on the nose. Intraoral involvement was observed in 37.9% of the cases, being the buccal mucosa the most frequent site. The predominant clinicai stage was T2b (9 cases, 31 %).Most patients did not show metastasis at the moment o f the diagnosis, however 1 O patients presented regional metastasis and two displayed distant metastasis. Microscopically, 18 cases (62.1%) were classified as embryonal, 10 (34.5%) as alveolar and 1 (3.4%) as pleomorphic. Immunohistochemical analysis for diagnosis showed positivity for desmin in

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Section: Análise Imunohistoquímicaunclassified

Analises clinica, histopatologica e imunohistoquimica de rabdomiossarcomas da região de cabeça e pescoço

Andrade¹,

Lopes²

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Die Bedeutung von Referenzzentren in Diagnose und Therapie von Weichgewebssarkomen der Extremitäten

Lehnhardt

Daigeler

Homann

et al. 2008

Chirurg

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Correct histopathologic diagnosis is essential for adequate treatment of soft tissue sarcomas. Due to the disorder's rarity, multitude of subgroups, sometimes varying histopathologic appearance, and occasionally inadequate biopsy specimens, diagnosis and grading are challenging. The records of 603 patients with soft tissue tumors of the extremities were reviewed concerning mismatches in primary and definite diagnoses relating to entity, evaluation of primary or recurrent tumor specimens, and the diagnosing pathology institution. For second opinions we referred to the Institute of Pathology of the Ruhr University at the Bergmannsheil Hospital in Bochum, Germany, and to the Pathology Institute of the University of Jena, also in Germany. Liposarcoma and malignant fibrous histiocytoma were the most often diagnosed subgroups at 24% and 22.6%, respectively. In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively. The diagnostic error ratio for nonspecialized pathologists in practice, community hospital pathologists, and academic medical centers was over 60%. For optimal treatment of soft tissue sarcomas, we suggest obtaining expert second opinion to ensure adequate surgical therapy and precise indications for radiation and chemotherapy.

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CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients

Greither

Wedler

Rot

et al. 2017

IJMS

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The capillary morphogenesis gene 2 (CMG2), also known as the anthrax toxin receptor 2 (ANTXR2), is a transmembrane protein putatively involved in extracellular matrix (ECM) adhesion and tissue remodeling. CMG2 promotes endothelial cell proliferation and exhibits angiogenic properties. Its downregulation is associated with a worsened survival of breast carcinoma patients. Aim of this study was to analyze the CMG2 mRNA and protein expression in soft tissue sarcoma and their association with patient outcome. CMG2 mRNA was measured in 121 tumor samples of soft tissue sarcoma patients using quantitative real-time PCR. CMG2 protein was evaluated in 52 tumor samples by ELISA. CMG2 mRNA was significantly correlated with the corresponding CMG2 protein expression (rs = 0.31; p = 0.027). CMG2 mRNA expression was associated with the mRNA expressions of several ECM and tissue remodeling enzymes, among them CD26 and components of the uPA system. Low CMG2 mRNA expression was correlated with a worsened patients’ disease-specific survival in Kaplan-Meier analyses (mean patient survival was 25 vs. 96 months; p = 0.013), especially in high-stage tumors. A decreased CMG2 expression is a negative prognostic factor for soft tissue sarcoma patients. CMG2 may be an interesting candidate gene for the further exploration of soft tissue sarcoma genesis and progression.

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Heterogeneity in Malignant Soft Tissue Tumors

Cited by 4 publications

References 160 publications

Analises clinica, histopatologica e imunohistoquimica de rabdomiossarcomas da região de cabeça e pescoço

Analises clinica, histopatologica e imunohistoquimica de rabdomiossarcomas da região de cabeça e pescoço

Die Bedeutung von Referenzzentren in Diagnose und Therapie von Weichgewebssarkomen der Extremitäten

CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients

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