Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA: Analysis of cancer registry data by the AC3

Auguste, Aviane; Gathere, Samuel; Pinheiro, Paulo Sérgio; Adebamowo, Clement; Akintola, Adeola; Alleyne-Mike, Kellie; Anderson, Simon; Ashing, Kimlin Tam; Awittor, Fred Kwame; Awuah, Baffour; Bhakkan, Bernard; Deloumeaux, Jacqueline; Plessis, Maira du; Ekanem, Ima-Obong; Ekanem, Uwemedimbuk Smart; Ezeome, Emmanuel; Felix, Nkese; Gachii, Andrew; Gaëte, Stanie; Gibson, TN; Hage, Robert; Harrison, Sharon; Igbinoba, Festus; Iseh, Kufre Robert; Kiptanui, Evans; Korir, Anne; Lawson-Myers, Heather-Dawn; Llanos, Adana A.M.; Luce, Danièle; McNaughton, D; Odutola, Michael; Omonisi, Abidemi; Otu, Theresa; Péruvien, Jessica; Raheem, Nasiru; Roach, Veronica; Sobers, Natasha; Uamburu, Nguundja; Ragin, Camille

doi:10.1016/j.canep.2021.102053

Cited by 3 publications

(3 citation statements)

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“…While limited data are currently available on cancer incidence among disaggregated NHB groups (18,19), a handful of studies show significant heterogeneity in cancer mortality by NHB subgroup in the US (20)(21)(22)(23). African-born NHBs have higher incidence of infection-related cancers (18) and Caribbean-born NHBs have lower risk of cancer mortality (20-23) compared to American-born NHBs, suggesting that the aggregation of all NHBs into a singular group in cancer surveillance masks withingroup differences and limits the ability to inform targeted intervention needs for higher-risk communities.…”

Section: Introductionmentioning

confidence: 99%

Variation in Cancer Incidence Rates Among Non-Hispanic Black Individuals Disaggregated by Nativity and Birthplace, 2005-2017: A Population-Based Cancer Registry Analysis

Llanos

Tsui

et al. 2022

Front. Oncol.

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ObjectivesCompared to other racial and ethnic groups, little to no disaggregated cancer incidence data exist for subgroups of non-Hispanic Blacks (NHBs), despite heterogeneity in sociodemographic characteristics and cancer risk factors within this group. Our objective was to examine age-adjusted cancer incidence by nativity and birthplace among NHB cancer cases diagnosed in New Jersey.MethodsRace, ethnicity, and birthplace data from the New Jersey State Cancer Registry were used to classify NHB cancer cases diagnosed between 2005-2017. Thirteen waves of population estimates (by county, nativity, gender, age-group) were derived from the American Community Survey using Integrated Public-Use Microdata to approximate yearly demographics. Age-adjusted cancer incidence rates (overall and by site) by birthplace were generated using SEER*Stat 8.3.8. Bivariate associations were assessed using chi-square and Fisher’s exact tests. Trend analyses were performed using Joinpoint 4.7.ResultsBirthplace was available for 62.3% of the 71,019 NHB cancer cases. Immigrants represented 12.3%, with African-born, Haitian-born, Jamaican-born, ‘other-Caribbean-born’, and ‘other-non-American-born’ accounting for 18.5%, 17.7%, 16.5%, 10.6%, and 36.8%, respectively. Overall, age-adjusted cancer incidence rates were lower for NHB immigrants for all sites combined and for several of the top five cancers, relative to American-born NHBs. Age-adjusted cancer incidence was lower among immigrant than American-born males (271.6 vs. 406.8 per 100,000) and females (191.9 vs. 299.2 per 100,000). Age-adjusted cancer incidence was lower for Jamaican-born (114.6 per 100,000) and other-Caribbean-born females (128.8 per 100,000) than African-born (139.4 per 100,000) and Haitian-born females (149.9 per 100,000). No significant differences in age-adjusted cancer incidence were observed by birthplace among NHB males. Age-adjusted cancer incidence decreased for all sites combined from 2005-2017 among American-born males, immigrant males, and American-born females, while NHB immigrant female rates remained relatively stable.ConclusionsThere is variation in age-adjusted cancer incidence rates across NHB subgroups, highlighting the need for more complete birthplace information in population-based registries to facilitate generating disaggregated cancer surveillance statistics by birthplace. This study fills a knowledge gap of critical importance for understanding and ultimately addressing cancer inequities.

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Section: Introductionmentioning

confidence: 99%

Variation in Cancer Incidence Rates Among Non-Hispanic Black Individuals Disaggregated by Nativity and Birthplace, 2005-2017: A Population-Based Cancer Registry Analysis

Llanos

Tsui

et al. 2022

Front. Oncol.

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“…In addition, the incidence ratio greatly increases for patients greater than 55 years of age. 18 Studies of the employment status of treated HNC patients in high-income countries report rates of discontinuing work of 34% -53%. 19,20 Others reported that 67% -83% of employed patients under the age of 65 years returned to work following diagnosis and treatment and 48% had reduced their workload.…”

Section: Discussionmentioning

confidence: 99%

Pain in head and neck cancer survivors in South Africa: A cross-sectional study

Patel,

Fung,

Gardiner

et al. 2024

Journal of the Colleges of Medicine of South Africa

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Background: Pain is often a significant symptom in patients with head and neck cancer (HNC). The objective of this study was to determine the prevalence of pain, factors limiting effective pain management, and whether differences in pain management exist between the public and private health sectors in South Africa in HNC patients after they have completed treatment.Methods: A cross-sectional survey using the Brief Pain Inventory was performed on adults over the age of 18 years treated for HNC of any subsite in both a public and private hospital in Cape Town, South Africa.Results: Overall pain scores indicated mild levels of pain and impact on daily activities. The domains of life most affected by pain were general activity, sleep and mood. There was no difference in pain scores between public hospital patients versus those with private insurance. Less than half of the patients reported receiving all their necessary medications. Most of the postoperative pain was managed with paracetamol, tramadol and ibuprofen, with only 12.8% of patients using morphine.Conclusion: This study provides a survey of pain experiences in HNC patients in a middle-income country. Insurance status did not significantly impact pain experiences, indicating equitable access to pain management resources. However, the overall utilisation of morphine and medications used to treat neuropathic pain is low. Further research is needed into the complex factors associated with pain in HNC patients.Contribution: This article is an example of a standard clinical study on patient-reported outcome measures.

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“…Head and neck cancer is a public health concern across the world, counting 700,000 new cases every year [ 1 ]. This incidence is particularly elevated in Guadeloupe and Martinique which have one of the highest rates among men in Latin America and the Caribbean [ 1 , 2 ] despite low prevalence of tobacco and alcohol [ 3 ]. Oral HPV infection is a prominent risk factor of head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Association between sexual behaviour and head and neck cancer in the French West Indies: a case-control study based on an Afro-Caribbean population

et al. 2023

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Background Worldwide, a significant proportion of head and neck cancers is attributed to the Human papillomavirus (HPV). It is imperative that we acquire a solid understanding of the natural history of this virus in head and neck squamous cell carcinoma (HNSCC) development. Our objective was to investigate the role of sexual behaviour in the occurrence of HNSCC in the French West Indies. Additionally, we evaluated the association of high risk of HPV (Hr-HPV) with sexual behaviour in risk of cancer. Methods We conducted a population-based case-control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds-ratios (OR), and their 95% confidence intervals (CI). Results Compared to persons who never practiced oral sex, those who practiced at least occasionally had a lower HNSCC risk. First sexual intercourse after the age of 18 year was associated with a 50% reduction of HNSCC risk, compared to those who began before 15 years. HNSCC risk was significantly reduced by 60% among persons who used condoms at least occasionally. The associations for ever condom use and oral sex were accentuated following the adjustment for high-risk HPV (Hr-HPV). Oral Hr-HPV was associated with several sexual behaviour variables among HNSCC cases. However, none of these variables were significantly associated with oral HPV infections in the population controls. Conclusion First intercourse after 18 years, short time interval since last intercourse and ever condom use were inversely associated with HNSCC independently of oral Hr-HPV infection. Sources of transmission other than sexual contact and the interaction between HPV and HIV could also play a role in HNSCC etiology.

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Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA: Analysis of cancer registry data by the AC3

Cited by 3 publications

References 41 publications

Variation in Cancer Incidence Rates Among Non-Hispanic Black Individuals Disaggregated by Nativity and Birthplace, 2005-2017: A Population-Based Cancer Registry Analysis

Variation in Cancer Incidence Rates Among Non-Hispanic Black Individuals Disaggregated by Nativity and Birthplace, 2005-2017: A Population-Based Cancer Registry Analysis

Pain in head and neck cancer survivors in South Africa: A cross-sectional study

Association between sexual behaviour and head and neck cancer in the French West Indies: a case-control study based on an Afro-Caribbean population

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