Abstract:Background
The origin of human Innate Lymphoid Cells (ILCs) remains less well characterised compared to mice. Single-cell RNA-sequencing recently revealed a population of ILC precursors (ILCP) expressing CD62L and CD45RA, which shows diversity in frequencies among blood, tonsil and intestine.
Objective
We set out to determine the differentiation capacity and epigenetic landscape of blood, tonsil and intestinal ILCP.
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