Heterogeneity and diversity of ABO and Rh blood group genes in select Saudi Arabian populations

AlSuhaibani, Entissar S.; Kizilbash, Nadeem; Malik, Sajid

doi:10.4238/2015.july.14.11

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…Most of this study's participants (89%) were RhD-positive. These results are comparable to previous results of other studies from other regions of KSA 22, 23, 24, 25, 26, 27…”

Section: Discussionsupporting

confidence: 92%

Relation between ABO blood groups and obesity in a Saudi Arabian population

Alwasaidi

Alrasheed

Alhazmi

et al. 2017

Journal of Taibah University Medical Sciences

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Objectives ABO blood groups have been shown to be associated with different diseases. Very few studies have attempted to detect the association of ABO blood groups with obesity. The goal of this study is to find any potential relation between ABO blood groups and high body mass index (BMI) among a Saudi population, which may contribute to underlying genetic disorders. Methods A cross-sectional descriptive study was conducted using a structured questionnaire that contained general demographic data, including weight, height, type of ABO blood group and the participants' opinion, to determine the association between the ABO blood groups and obesity. Results Our study included 1171 participants, including 596 (50.9%) women. A plurality of participants' ages (47%) was between 15 and 25 years. The prevalence of obesity was 35.7% in men and 20.3% in women, while the prevalence of overweight was 30% in men and 25.3% in women. Blood group O was reported to be the most common blood group (46%), followed by blood group A (31.4%), while blood groups B and AB were found in 16.1% and 6.5% of participants, respectively. The prevalence of obesity (BMI ≥ 30) among participants based on blood group O, A, B, and AB was 13.7%, 9%, 4.8%, and 2.2%, respectively. There was no statistically significant difference between the prevalence of obesity or high BMI and ABO blood groups. Conclusion Overall, our study did not show a significant relation between overweight and obesity and ABO blood groups. However, the elevation of the prevalence of overweight and obesity, mainly among the younger generations of the Saudi population, requires more awareness and educational programs.

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“…Most of this study's participants (89%) were RhD-positive. These results are comparable to previous results of other studies from other regions of KSA 22, 23, 24, 25, 26, 27…”

Section: Discussionsupporting

confidence: 92%

Relation between ABO blood groups and obesity in a Saudi Arabian population

Alwasaidi

Alrasheed

Alhazmi

et al. 2017

Journal of Taibah University Medical Sciences

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“…Furthermore, the loss of heterozygosity observed in rs2066845 may be because of widespread consanguinity in the Saudi population. Similar observations were made by AlSuhaibani et al (2015) in their study on ABO and Rh blood group polymorphisms in a Saudi population (AlSuhaibani et al, 2015).…”

Section: Discussionsupporting

confidence: 85%

Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection

Al-Anazi

Nazir

Abdo

et al. 2019

Saudi Journal of Biological Sciences

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Objectives: Nucleotide oligomerization domain 2 (NOD2) and myeloid differentiation protein 2 (MD-2) have crucial roles in the innate immune system. NOD2 is a member of the NOD-like receptor (NLR) family of pattern recognition receptors (PRRs), while MD-2 is a co-receptor for Toll-like receptor 4 (TLR4), which comprises another group of PRRs. Genetic variations in the NOD2 and MD-2 genes may be susceptibility factors to viral pathogens including hepatitis B virus (HBV). We investigated whether polymorphisms at NOD2 (rs2066845 and rs2066844) or at MD-2 (rs6472812 and rs11466004) were associated with susceptibility to HBV infection and advancement to related liver complications in a Saudi Arabian population. Methods: A total of 786 HBV-infected patients and 600 healthy uninfected controls were analyzed in the present study. HBV-infected patients were categorized into three groups based on the clinical stage of the infection: inactive HBV carriers, active HBV carriers, and patients with liver cirrhosis + hepatocellular carcinoma (HCC). Results: All four SNPs were significantly associated with susceptibility to HBV infection although none of the SNPs tested in NOD2 and MD-2 were significantly associated with persistence of HBV infection. We found that HBV-infected patients that were homozygous CC for rs2066845 in the NOD2 gene were at a significantly increased risk of progression to HBV-related liver complications (Odds Ratio = 7.443 and P = 0.044). Furthermore, haplotype analysis found that the rs2066844-rs2066845 C-G and T-G haplotypes at the NOD2 gene and four rs6472812-rs11466004 haplotypes (G-C, G-T, A-C, and A-T) at the MD-2 gene were significantly associated with HBV infection in the affected cohort compared to those found in our control group. Conclusion: We found that the single nucleotide polymorphisms rs2066844 and rs2066845 at NOD2 and rs6472812 and rs11466004 at MD-2 were associated with susceptibility to HBV infection in a Saudi population.

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“…However, reports of blood group phenotypes in Saudi Arabia are limited to the ABO and RhD blood group systems. [3][4][5][6][7] No reports on the distribution of the various blood group phenotypes are available in the Eastern region of Saudi Arabia. Saudi Arabia is a large and multi-national country with a diverse ethnic background, particularly in the East and West because of its proximity to the sea, resulting in a long history of immigration.…”

Section: Introductionmentioning

confidence: 99%

<p>Phenotype Frequencies of Major Blood Group Systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) Among Blood Donors in the Eastern Region of Saudi Arabia</p>

Owaidah¹,

Naffaa²,

Alumran³

et al. 2020

JBM

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Introduction: The understanding of blood group phenotypes in Saudi Arabia is limited to the ABO and Rh blood groups. Data for the other major blood group phenotypes in different populations have been widely studied and used as a reference for identifying antigennegative blood in hospital blood banks. Such information is crucial for facilitating the challenging task of providing antigen-negative blood for patients with multiple antibodies. Objective: The aim of this study was to determine the frequency of the major blood group phenotypes in the Eastern region of Saudi Arabia and compare them to phenotypes in other populations. Methods: A total of 100 volunteer Saudi donors were included in this study. Red blood cells from the donors were subjected to antigen typing of the major blood group systems (Rh, Kell, Kidd, Duffy, MNS, Lewis, Lutheran, and P) using the gel microtube technique. Results: From the Rh blood group system, the e antigen was found in 97% of donors, followed by c at 86%. The Cellano (k) antigen of the Kell system was found in all donors, whereas the Kell (K) antigen was only found in 8 % of donors. The K+k-phenotype was not detected in our study. Unexpectedly, for the Duffy blood group system, the null phenotype Fy (a-b-) was found in 61% of donors. In the MNS blood group system, M+N-S+s+ was the most common phenotype at 24%. Conclusion: The frequency of blood group phenotypes in the Eastern region of Saudi Arabia differs from that in other populations because of the diverse ethnic backgrounds of those living in that region. The findings of this study can be used to establish a local donor registry to help provide antigen-negative blood for patients with unexpected antibodies or to create an in-house antibody identification panel to add to the commercial panel that would be useful for confirming antibody identification results.

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Heterogeneity and diversity of ABO and Rh blood group genes in select Saudi Arabian populations

Cited by 8 publications

References 11 publications

Relation between ABO blood groups and obesity in a Saudi Arabian population

Relation between ABO blood groups and obesity in a Saudi Arabian population

Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection

<p>Phenotype Frequencies of Major Blood Group Systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) Among Blood Donors in the Eastern Region of Saudi Arabia</p>

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