Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings

Battisti, Antonio; Franco, Alessia; Merialdi, G.; Hasman, Henrik; Iurescia, Manuela; Lorenzetti, Raniero; Feltrin, Fabiola; Zini, Maurizio; Aarestrup, Frank Møller

doi:10.1016/j.vetmic.2009.10.008

Cited by 136 publications

(147 citation statements)

References 32 publications

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“…Most of the CA-MRSA strains circulating in our country were included in USA300 clone or its Latin American variant mainly due to the large population exchanges with American continent in recent years. 24,25 The presence of this clone was low (five isolates) in our hospital environment. Three isolates, belonging to Bolivian patients, contained the lukF/lukS-PV genes.…”

Section: Discussionmentioning

confidence: 76%

Antimicrobial resistance, virulence factors and genetic lineages of hospital-onset methicillin-resistant Staphylococcus aureus isolates detected in a hospital in Zaragoza

González-Domínguez

Seral

Potel

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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Please cite this article in press as: González-Domínguez M, et al. b s t r a c tIntroduction: MRSA population dynamics is undergoing significant changes, and for this reason it is important to know which clones are circulating in our nosocomial environment. Materials and methods: A total of 118 MRSA isolates were collected from clinical samples from patients with previous hospital or healthcare contact (named as hospital-onset MRSA (HO-MRSA)) during a one year period. Susceptibility testing was performed by disk diffusion and microdilution. The presence of resistance genes and virulence factors were tested by PCR. All isolates were typed by SCCmec, spa and agr typing. PFGE and MLST were applied to a selection of them.Results: Eighty-three HO-MRSA isolates (70.3%) were resistant to any antibiotic included in the macrolide-lincosamide-streptogramin B group. Among these isolates, the M phenotype was the most frequent (73.5%). One hundred and seven of HO-MRSA isolates (90.7%) showed aminoglycoside resistance. The combination aac(6 )-Ie-aph(2 )-Ia + ant (4 ) El CC5 fue el más prevalente (88,1%) seguido de CC8 (5,9%), CC22 (2,5%), CC398 (2,5%) y CC1 (0,8%). Conclusión: La línea clonal CC5/ST125/t067 fue la más habitual. Esta línea se relacionó con resistencia a aminoglucósidos, y, en menor medida, con macrólidos. La presencia de clones internacionales como EMRSA-15 (CC22/ST22), clones europeos como CC5/ST228, clones comunitarios relacionados con CC1 o CC8 y clones asociados al ganado, como el CC398, se observaron en un bajo porcentaje. ARTICLE IN PRESSG Model EIMC 1282 1-7 2 M. González-Domínguez et al. / Enferm Infecc Microbiol Clin. 2015;xxx(xx):xxx-xxx

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Section: Discussionmentioning

confidence: 76%

Antimicrobial resistance, virulence factors and genetic lineages of hospital-onset methicillin-resistant Staphylococcus aureus isolates detected in a hospital in Zaragoza

González-Domínguez

Seral

Potel

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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“…The first time an ST9 strain was found in Europe was in 2008, in Italy, although the most prevalent ST was the typical European ST398 [3]. Since then, LA-MRSA ST9 isolates have been detected in pigs [48] and poultry [69] from Germany and in retail meat from the UK [70].…”

Section: Cc9mentioning

confidence: 99%

“…According to EspinosaGongora et al [71], the first European CC9 isolates were discovered between 1973 and 2009 and carried diverse spa types (t337, t526, t899, t1334, t2498, t3446). The European isolates found recently carry mainly spa types t337 [48], t1430 [48,69], t1939 [70], and t4794 [3]. CC9 Asian isolates carry diverse spa types, such as t899, t4358, and t337 [17].…”

Section: Cc9mentioning

confidence: 99%

“…MRSA ST97 was first discovered in Italy in pigs [3]. Later, CC97 was found in Spain, being the first isolate of a new single locus variant of ST97, namely, ST1379 [84].…”

Section: Cc97mentioning

confidence: 99%

“…The number of staphylococcal protein A gene (spa) types within CC398 is nowadays increasing [2•]. Furthermore, other S. aureus lineages among animals have acquired methicillin resistance [3]. Moreover, it is obvious that the spread of MRSA in livestock differs geographically, with CC398 being the most prevalent CC in Europe and USA and CC9 predominating in LA-MRSA cases in Asia.…”

Section: Introductionmentioning

confidence: 99%

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Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Evolution, Characteristics, and Clonal Expansion of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA): Global Perspectives

Hamza

Sivaraman

Mothadaka

2023

Handbook on Antimicrobial Resistance

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Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings

Cited by 136 publications

References 32 publications

Antimicrobial resistance, virulence factors and genetic lineages of hospital-onset methicillin-resistant Staphylococcus aureus isolates detected in a hospital in Zaragoza

Antimicrobial resistance, virulence factors and genetic lineages of hospital-onset methicillin-resistant Staphylococcus aureus isolates detected in a hospital in Zaragoza

Livestock-Associated MRSA and Its Current Evolution

Evolution, Characteristics, and Clonal Expansion of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA): Global Perspectives

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