Abstract:<p>El origen, la función y el repertorio de las células B de memoria IgM humanas (caracterizadas por ser positivas para CD27 IgM e IgD) son controvertidos, y se ha propuesto que esta población es heterogénea. Aunque algunas veces contradictorias, las evidencias actuales apuntan a la existencia de por lo menos dos subpoblaciones de dichas células en sangre: por un lado, células B circulantes de la zona marginal del bazo, con algunas características similares a las células innatas y probablemente responsab… Show more
“…IgM hi B cells have characteristics of MZB cells with features of post-germinal center Bmem cells, the frequency of which may increase with age (56), as B cells entering germinal centers. These characteristics of IgM hi B cells are in agreement with the current literature concerning IgM + IgD + CD27 + B cells (10)(11)(12)(13) and are consistent with the concept that their heterogeneity is generated by gradual recruitment of MZB cells into germinal center responses (35). In contrast, our findings with IgM lo B cells seem novel: IgM lo B cells display markers of MZPc (26,27), the frequencies of which decrease with age (26,56), have some clonal relationships with IgM hi B cells, and appear less differentiated, suggesting that IgM lo B cells may be the precursors of IgM hi B cells.…”
Section: Discussionsupporting
confidence: 92%
“…Human circulating IgM + IgD + CD27 + B cells are considered a heterogeneous population (9)(10)(11)(12)(13)(14)(15), probably composed at least by B cells of the marginal zone (MZB cells) of the spleen circulating in peripheral blood (13,16) and by IgM Bmem cells with an adaptive function that entered the germinal centers (17,18). However, it is debatable if these cells are generated from germinal center responses or independently of T-cell help (14,16,18,19).…”
“…IgM hi B cells have characteristics of MZB cells with features of post-germinal center Bmem cells, the frequency of which may increase with age (56), as B cells entering germinal centers. These characteristics of IgM hi B cells are in agreement with the current literature concerning IgM + IgD + CD27 + B cells (10)(11)(12)(13) and are consistent with the concept that their heterogeneity is generated by gradual recruitment of MZB cells into germinal center responses (35). In contrast, our findings with IgM lo B cells seem novel: IgM lo B cells display markers of MZPc (26,27), the frequencies of which decrease with age (26,56), have some clonal relationships with IgM hi B cells, and appear less differentiated, suggesting that IgM lo B cells may be the precursors of IgM hi B cells.…”
Section: Discussionsupporting
confidence: 92%
“…Human circulating IgM + IgD + CD27 + B cells are considered a heterogeneous population (9)(10)(11)(12)(13)(14)(15), probably composed at least by B cells of the marginal zone (MZB cells) of the spleen circulating in peripheral blood (13,16) and by IgM Bmem cells with an adaptive function that entered the germinal centers (17,18). However, it is debatable if these cells are generated from germinal center responses or independently of T-cell help (14,16,18,19).…”
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