Heterodyne holography with full control of both the signal and reference arms

Gross, Michel

doi:10.1364/ao.55.0000a8

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…In this work, we explore an alternative approach to DCS measurements that employs a holographic method known as heterodyne parallel speckle detection (HPSD). HPSD has been well described in the literature since its inception in 2003 [15][16][17][18]. The experimental configuration of an HPSD system consists of a Mach-Zender interferometer, where the reference and sample arms are recombined and interfere on a digital camera.…”

Section: Holographic Techniquesmentioning

confidence: 99%

“…The sample and reference beams are recombined in a beamsplitter and are interfered on a camera sensor. This recombination occurs slightly off-axis with respect to the camera sensor by a small tilt angle [16].…”

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

“…For phase-shifting with N f = 2, H C is constructed according to Eq. (18), whilst for phase-shifting with N f = 4, H C is constructed as [16]…”

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

“…3). The interested reader is referred to [16] for further information regarding the formation of multiple frame holograms. The expression for the IRF for the first and second heterodyne terms of an HPSD instrument is given by [15,28]…”

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

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Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection

James¹,

Powell²

2020

Biomed. Opt. Express

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We present a new approach to diffuse correlation spectroscopy which overcomes the limited light throughput of single-mode photon counting techniques. Our system employs heterodyne holographic detection to allow parallel measurement of the power spectrum of a fluctuating electric field across thousands of modes, at the shot noise limit, using a conventional sCMOS camera. This yields an order of magnitude reduction in detector cost compared to conventional techniques, whilst also providing robustness to the effects of ambient light and an improved signal-to-noise ratio during in vitro experiments. We demonstrate a GPU-accelerated holographic demodulation system capable of processing the incoming data (79.4 M pixels per second) in real-time, and a novel Fourier domain model of diffuse correlation spectroscopy which permits the direct recovery of flow parameters from the measured data. Our detection and modelling strategy are rigorously validated by modulating the Brownian component of an optical tissue phantom, demonstrating absolute measurements of the Brownian diffusion coefficient in excellent agreement with conventional methods. We further demonstrate the feasibility of our system through in vivo measurement of pulsatile flow rates measured in the human forearm.

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Section: Holographic Techniquesmentioning

confidence: 99%

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

“…For phase-shifting with N f = 2, H C is constructed according to Eq. (18), whilst for phase-shifting with N f = 4, H C is constructed as [16]…”

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

Section: Heterodyne Parallel Speckle Detectionmentioning

confidence: 99%

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Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection

James¹,

Powell²

2020

Biomed. Opt. Express

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“…HPSD has been well described in the literature since its inception in 2003. [10][11][12][13] The experimental configuration consists of a Mach-Zender interferometer, where the reference and sample arms are combined and interfere on a digital camera. Temporal filtering occurs over the camera integration period, and the resulting images record the first-order power spectral density of the scattered electric field, S 1 , at a particular frequency.…”

Section: Introductionmentioning

confidence: 99%

Diffuse correlation spectroscopy in the Fourier domain with holographic camera-based detection

James

Powell

2020

Dynamics and Fluctuations in Biomedical Photonics XVII

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We present a new approach to Diffuse Correlation Spectroscopy (DCS) which overcomes the limited light throughput of single mode photon counting techniques, and operates with continuous wave illumination without disturbance from ambient light. Heterodyne holographic detection allows parallel measurement of the power spectrum of a fluctuating electric field across thousands of modes, from which we may directly compute flow parameters using a novel Fourier domain DCS model. Our detection and modelling strategy are rigorously validated by modulating the Brownian and flow components of an optical tissue phantom, demonstrating absolute measurements of the Brownian diffusion coefficient in excellent agreement with conventional methods. We demonstrate the feasability of in vivo measurement through the recovery of pulsatile flow rates measured in the human forearm.

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Camera-based ultrasound-modulated optical tomography with isometric resolution

Lin,

Wu,

Zhao

et al. 2024

Applied Physics Letters

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Ultrasound-modulated optical tomography (UOT) leverages the strengths of light and sound, enabling deep-tissue imaging with optical absorption contrast and acoustic resolution. Camera-based UOT, with its parallel detection capability, excels at handling weak light–sound interactions. However, the limited frame rate of the camera typically results in poor axial resolution and poses challenges for holographic measurements. In this study, we introduced intersected ultrasonic modulation to address these limitations, thereby achieving equal resolution in both lateral and axial dimensions through referenceless measurements. As a proof of concept, we constructed an imaging system and demonstrated two-dimensional imaging for absorptive targets buried inside a scattering medium. This approach opens avenues for improved imaging resolutions, showcasing the potential for future diagnostic endeavors.

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Heterodyne holography with full control of both the signal and reference arms

Cited by 12 publications

References 40 publications

Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection

Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection

Diffuse correlation spectroscopy in the Fourier domain with holographic camera-based detection

Camera-based ultrasound-modulated optical tomography with isometric resolution

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