Heterocyclic synthesis via enaminones: Regioselective synthesis of some novel pyrazole, isoxazole, pyrimidine, pyrido[1,2-a]benzimidazole and pyrazolo[1,5-a]-pyrimidine derivatives

Dawood, Kamal M.; Kandeel, Zaghloul E.; Farag, Ahmad M.

doi:10.1002/(sici)1098-1071(1999)10:5<417::aid-hc12>3.0.co;2-3

Cited by 15 publications

(1 citation statement)

References 19 publications

(18 reference statements)

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“…Pyrimidines and pyridazines have been known for chemists 1,2 and functionalized pyrimidopyridazines are known in the recent years to attract much attention due to their importance in biological and pharmaceutical research. [3][4][5] Several reports on synthesis and biological evaluation of pyrimido [4,5-d]pyridazine-8(7H)-ones are available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate

Karami

Akrami²,

Khodabakhshi³

2013

Bulletin of the Korean Chemical Society

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Novel tri-and tetra-substituted pyrimido [4,5-d]pyridazines-2(1H,3H,7H)-ones have been synthesized via the regiospecific condensation reaction of hydrazine derivatives with 5-acetyl-4-aryloyl-6-methyl-3,4-dihydropyrimidinones in the presence of SiO 2 -Y(NO 3 ) 3 as a green and recyclable catalyst under solvent-free conditions. All products were obtained in high yields and short reaction time. Employing this method is in accord with green chemistry principles.

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Section: Introductionmentioning

confidence: 99%

Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate

Karami

Akrami²,

Khodabakhshi³

2013

Bulletin of the Korean Chemical Society

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ChemInform Abstract: Heterocyclic Synthesis via Enaminones: Regioselective Synthesis of Some Novel Pyrazole, Isoxazole, Pyrimidine, Pyrido[1,2‐a]benzimidazole, and Pyrazolo[1,5‐a]pyrimidine Derivatives

1999

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L‐Proline‐Catalyzed Activation of Methyl Ketones or Active Methylene Compounds and DMF‐DMA for Syntheses of (2E)‐3‐Dimethylamino‐2‐ propen‐1‐ones

et al. 2012

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A cascade organocatalysis is reported for the nucleophilic and electrophilic dual activation taking place in the reaction of methyl ketones or active methylene compounds with DMF‐DMA (N,N‐dimethylformamide dimethyl acetal). L‐Proline serves as an efficient organocatalyst in the covalent and noncovalent synchronous mode for the ambiphilic activation of various aryl, heteroaryl, and styryl methyl ketones, cyclic ketones, and 1,3‐diketones with DMF‐DMA to achieve the convenient syntheses of the versatile synthons (2E)‐1‐aryl/heteroaryl/styryl‐3‐(dimethylamino)‐2‐propen‐1‐ones, (E)‐α‐[(dimethylamino)formylidene]cycloalkanones, and (E)‐2‐(dimethylamino)formylidene‐1,3‐diketones in high yields under solvent‐free conditions.

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Heterocyclic synthesis via enaminones: Regioselective synthesis of some novel pyrazole, isoxazole, pyrimidine, pyrido[1,2-a]benzimidazole and pyrazolo[1,5-a]-pyrimidine derivatives

Cited by 15 publications

References 19 publications

Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate

Novel Tri- and Tetra-substituted Pyrimido[4,5-d]pyridazines: Regiospecific Synthesis Catalyzed by Silica Supported Yttrium Trinitrate

ChemInform Abstract: Heterocyclic Synthesis via Enaminones: Regioselective Synthesis of Some Novel Pyrazole, Isoxazole, Pyrimidine, Pyrido[1,2‐a]benzimidazole, and Pyrazolo[1,5‐a]pyrimidine Derivatives

L‐Proline‐Catalyzed Activation of Methyl Ketones or Active Methylene Compounds and DMF‐DMA for Syntheses of (2E)‐3‐Dimethylamino‐2‐ propen‐1‐ones

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