Heterocyclic substituted ureas. II. Immunosuppressive and antiviral activity of benzothiazolyl- and benzoxazolylureas

Fe3O4@SiO2–ZrCl2‐MNPs: A novel magnetic catalyst for the clean and efficient cascade synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthol derivatives in the absence of solvent

“…[3] Benzothiazole and its derivatives are of interesting compounds because they found in many natural products and pharmaceuticals. [4] These compounds were reported to possess anti-inflammatory, [5] anti-tumor, [6] anti-convulsant, [7] anti-bacterial, [8] anti-fungal, [9] and topoisomerase II inhibitory activities. [10] Among them, 1-(benzothiazolylamino)phenyl-methyl-2-naphthols have two biologically active parts, 2-aminobenzothiazole and Betti 0 s base.…”

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“…As an intermediate 2-aminobenzothiazoles are broadly found in bioorganic and medicinal chemistry with applications in drug discovery and development for the treatment of diabetes [7][8][9][10][11][12][13][14][15][16] , epilepsy [17][18][19][20][21][22][23] , inflammation, 24 analgesia, 25,26 amyotrophic lateral sclerosis, 27 and viral infections 28 . They also exhibits antitumor [29][30][31][32][33][34][35][36][37][38][39][40][41][42] , antitubercular 43 , antibacterial 44,45 , antifungal [46][47] , antimalarial 48 , antihelmintic 49 .…”

Synthesis of 2-Arylbenzothiazoles Catalyzed by Biomimetic Catalyst, β-Cyclodextrin

“…2 Their significance is also due to their applications in the treatment of autoimmune, inflammatory, epilepsy, analgesia, viral, cancer, tuberculosis diseases, and the prevention of organ transplant rejection. [3][4][5][6][7][8][9] Also, they have been widely used in industry as antioxidants and vulcanization accelerators that highlight their synthetic necessity. 10 Numerous methods have been reported in the literature for the synthesis of benzothiazoles.…”