Biochemical Pharmacology volume 76, issue 8, P974-986 2008 DOI: 10.1016/j.bcp.2008.07.038 View full text
Katsuya Iuchi, Yukichi Hatano, Tatsuo Yagura

Abstract: We have synthesized novel heterocyclic organobismuth compounds that have potent antibacterial properties. In this study, we examined their anticancer activity and addressed the cellular mechanisms involved. Heterocyclic organobismuth compounds showed anticancer activities in various human cancer cell lines. These compounds have particularly potent anticancer activities against leukemia cell lines. One of them, bi-chlorodibenzo [c,f][1,5] thiabismocine (compound 3), inhibited the growth of the human promyelocyt…

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