Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation

Abstract

Eight hetereocyclic compounds conflamides B-I with an unprecedented skeleton and their precursor conflamide A were isolated from the mushroom Albatrellus confluens. Their structures and absolute configurations were determined by use of NMR studies, total synthesis, and calculated ECD spectra. Conflamides D and E were found to exhibit potent inhibition against LPS-induced B lymphocyte cell proliferation with IC values 1.48 and 5.71 μM, respectively.

Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica

“…Compounds 1 and 2 showed no cytotoxicity against five human cancer cell lines (HL-60, A-549, SMMC-7721, SW480, MCF-7). They were evaluated for their in vitro inhibition activities on concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B cell proliferation. , Compound 2 was found to exhibit potent inhibitions against concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation with IC 50 values 13.3 and 7.5 μM, respectively. Compound 1 exhibited significant inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC 50 value 18.6 μM.…”

Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana

“…In another way, based on the relative configuration as deduced above, the stereochemistry of C-18 was established by gauge-independent atomic orbital (GIAO) 13 C NMR calculations. 18 As given in Table 2 and shown in Figure 4, the calculated data for 2a matched the experiment data with much better values of mean absolute errors (MSE) and root-mean-square (RMS), suggesting an S* form for C-18. Subsequently, the ECD calculations established the absolute configuration of 2 (Figure 5).…”

Trichothecrotocins A–C, Antiphytopathogenic Agents from Potato Endophytic Fungus Trichothecium crotocinigenum

“…In spite of this, several potato diseases caused by plant pathogens, such as Phytophthora infestans (late blight), Alternaria solani (early blight), Rhizoctonia solani (black scurf), and Fusarium oxysporum (blast), have caused substantial problems in the production of potatoes. , Nowadays, common “fighters” against the microorganisms are numerous synthetic fungicides that, besides benefits, have also side effects on host and environment and can cause the development of fungicide resistance in the pathogens. − Therefore, it is urgent to look for new and effective natural fungicides. Recently we have reported chemically various natural products with different activities from fungi; − in this Letter, we focused on the secondary metabolites of the potato endophytic fungi and their antifungal activity against the potato pathogens.…”

“…On the basis of the relative configuration, the absolute configuration of 1 was established by calculating electronic circular dichroism (ECD) using the methods we reported previously with minor modifications (Figure , see the Supporting Information). , The ECD spectra of the major conformers were calculated using the mPW1PW91/6-311G­(d) level of theory with the IEF-PCM solvent model (MeOH). The calculated ECD spectra of 1a were quite similar to the experimental data.…”