Heterocyclic chalcone (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(thiophen-2-yl) prop-2-en-1-one derived from a natural product with antinociceptive, anti-inflammatory, and hypoglycemic effect in adult zebrafish

Ferreira, Maria Kueirislene Amâncio; Freitas, William Rodrigues de; Barbosa, Italo Moura; Rocha, Matheus Nunes da; Silva, Antônio Wlisses da; Rebouças, Emanuela de Lima; Mendes, Francisco Rogênio da Silva; Alves, Carlúcio Roberto; Nunes, Paulo Iury Gomes; Marinho, Márcia Machado; Furtado, Roselayne Ferro; Santos, Flávia Almeida; Marinho, Emanuelle Machado; Menezes, Jane Eire Silva Alencar de; Santos, Hélcio Silva dos

doi:10.1007/s13205-023-03696-8

3 Biotech

2023

DOI: 10.1007/s13205-023-03696-8

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Heterocyclic chalcone (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(thiophen-2-yl) prop-2-en-1-one derived from a natural product with antinociceptive, anti-inflammatory, and hypoglycemic effect in adult zebrafish

Maria Kueirislene Amâncio Ferreira

William Rodrigues de Freitas

Italo Moura Barbosa

et al.

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2024

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Cited by 2 publications

References 107 publications

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Withanicandrin Isolated from Datura Ferox Promotes Antinociception by Modulating the Asics and TRPS Channels and Anti‐Inflammation in Adult Zebrafish

Maciel,

Liberato,

da Silva

et al. 2024

Chemistry & Biodiversity

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This is the first study to analyze the anti‐inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ‐Carrageenan 1.5% and a Molecular Docking study. As a result, withanicandrin reduced nociceptive behavior by capsaicin at a dose of 40 mg/kg and by acid saline at doses of 4 and 40 mg/kg, through neuromodulation of TRPV1 channels and ASICs, identified through blocking the antinociceptive effect of withanicandrin by the antagonists capsazepine and naloxone. Furthermore, withanicandrin caused an anti‐inflammatory effect through the reduction of abdominal edema, absence of leukocyte infiltrate in the liver tissue and reduction of ROS in thel liver tissue and presented better affinity energy compared to control morphine (TRPV1) and ibuprofen (COX‐1 and COX‐2).

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Withanicandrin Isolated from Datura Ferox Promotes Antinociception by Modulating the Asics and TRPS Channels and Anti‐Inflammation in Adult Zebrafish

Maciel,

Liberato,

da Silva

et al. 2024

Chemistry & Biodiversity

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Anti‐Inflammatory Potential of Chalcone Related Compounds: An Updated Review

Yadav,

Sharma,

Singh

2024

ChemistrySelect

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Inflammation is a physiological process that involves a variety of inflammatory mediators such as PGE2, Nitric oxides, PLA2 etc., blocking these mediators could be helpful in designing and development of promising anti‐inflammatory compounds. Non‐steroidal anti‐inflammatory drugs (NSAIDs) have been used for the treatment of inflammatory‐related disorders via variety of pathways that include inhibition of COX‐1, COX‐2, LOX, NO etc. Chalcone derivatives, characterized by their unique chemical structure, have emerged as potential candidates for modulating inflammatory pathways. Literature suggested that modifications in chalcone derivatives by targeting different molecular targets could leads to the development of potential anti‐inflammatory agents. In this review, we have summarised representative chalcone derivatives against different anti‐inflammatory targets and discussed their structure‐activity relationship along with relevant data.

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Heterocyclic chalcone (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(thiophen-2-yl) prop-2-en-1-one derived from a natural product with antinociceptive, anti-inflammatory, and hypoglycemic effect in adult zebrafish

Cited by 2 publications

References 107 publications

Withanicandrin Isolated from Datura Ferox Promotes Antinociception by Modulating the Asics and TRPS Channels and Anti‐Inflammation in Adult Zebrafish

Withanicandrin Isolated from Datura Ferox Promotes Antinociception by Modulating the Asics and TRPS Channels and Anti‐Inflammation in Adult Zebrafish

Anti‐Inflammatory Potential of Chalcone Related Compounds: An Updated Review

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