Heterochromatin in the 4<sup>th</sup>Chromosome of<i>D. Melanogaster</i>

Barigozzi, Claudio; Fraccaro, M.; Halfer, C.

doi:10.1080/00087114.1977.10796692

Cited by 6 publications

(2 citation statements)

References 8 publications

(2 reference statements)

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“…However, l(1)mbn blood cells phagocytose and encapsulate their own tissues and resemble thus the blood cell behavior of melanotic pseudotumor mutants (39). Mutant blood cells often encapsulate and melanize the posterior fat body which leads to the formation of melanotic masses.…”

Section: Malignant Blood Cell Neoplasmsmentioning

confidence: 99%

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Gateff

1978

Science

445

309

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Malignant neoplasms that develop in 12 recessive-lethal, larval mutants of Drosophila melanogaster are discussed. These mutations affect the adult optic neuroblasts and ganglion-mother cells in the larval brain, the imaginal discs, and the hematopoietic organs. The malignant neoplasms exhibit fast, autonomous growth, loss of the capacity for differentiation, increased mobility and invasiveness, lethality in situ and after transplantation, and histological, fine structural, and karyotypic abnormalities. Intermediate neoplasms are also found. These combine both benign and malignant qualities. They grow in a noninvasive, compact fashion, typical of benign tumors, yet they also exhibit malignant qualities such as fast, autonomous, and lethal growth, loss of differentiation capacity, changes in cellular morphology, and lethal growth after transplantation into wild-type hosts. Thus Drosophila and vertebrate neoplasms show striking similarities.

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Section: Malignant Blood Cell Neoplasmsmentioning

confidence: 99%

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Gateff

1978

Science

445

309

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“…We could not confirm that the heterochromatic regions of D. melanogaster chromosomes during mitosis are permanently asynapsed (Halfer & Barigozzi, 1972) because we observed disturbance of pairing in these regions (26.6%; 7,4%; 6,4% for the pairs of metaphase chromosomes X, 2 and 3, respectively) only in part of the cells. At the same time, the low frequency of pairing of chromosomes 4 argues in favour of their being fused mostly in euchromatic regions (Barigozzi et al, 1977).…”

Section: The Unity Of Honologous and Heterologous Association Of Chrmentioning

confidence: 99%

Somatic synapsis of eu- and heterochromatic regions of Drosophila melanogaster chromosomes

Semionov

Smirnov

1984

Genetica

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Quantitative cytogenetical analysis has been used to study the synapsis of D. melanogaster neuroblast mitotic chromosomes from normal females, flies with heterozygous deletions, duplications or inversions in the heterochromatic regions of chromosome 2 and in triploid females. In all these genotypes chromocentric fusion of heterochromatic regions of heterologous chromosomes is observed. Eu-and heterochromatic regions of homologous chromosomes are intimately paired at the same time during the cell cycle. The structural rearrangements lead to reduced frequencies of chromocentric association as well as of homologous synapsis compared with the frequencies in the wild-type. The results obtained are discussed with respect to the general problem of the homologous interaction of chromosomes and the significance of heterochromatin for these processes.

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Karyotypic evolution in an originally XY cell line of Drosophila melanogaster

Halfer

1978

Chromosoma

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The cell line Ca of Drosophila melanogaster, characterized initially by a nearly diploid and normal male karyotype (XY), was used to study chromosomal variation over a period of 5 years of cultivation in vitro. Some general aspects of cell population dynamics which are in accordance with previous findings are pointed out. Various phenomena regarding chromosomal changes leading to karyotype polymorphism are outlined, with a particular emphasis being given to the sex chromosomes. Accordingly, with the aid of fluorescence analysis, some features of the Y and the X chromosomes providing evidence of an enlargement of the heterochromatin (due to addition and to saltatory replication) are described. Moreover, a case of variation in cell morphology accompanied by karyotypic changes was observed, as well as the emergence of a new cell subline of XX type derived from the original of XY type.

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Heterochromatin in the 4^thChromosome ofD. Melanogaster

Cited by 6 publications

References 8 publications

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Somatic synapsis of eu- and heterochromatic regions of Drosophila melanogaster chromosomes

Karyotypic evolution in an originally XY cell line of Drosophila melanogaster

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Heterochromatin in the 4thChromosome ofD. Melanogaster

Cited by 6 publications

References 8 publications

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

Somatic synapsis of eu- and heterochromatic regions of Drosophila melanogaster chromosomes

Karyotypic evolution in an originally XY cell line of Drosophila melanogaster

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Heterochromatin in the 4^thChromosome ofD. Melanogaster