Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals
Brandon Lu,
Yoel P. Ohayon,
Karol Woloszyn
et al.
Abstract:Metal-mediated DNA (mmDNA) presents a pathway toward
engineering
bioinorganic and electronic behavior into DNA devices. Many chemical
and biophysical forces drive the programmable chelation of metals
between pyrimidine base pairs. Here, we developed a crystallographic
method using the three-dimensional (3D) DNA tensegrity triangle motif
to capture single- and multi-metal binding modes across granular changes
to environmental pH using anomalous scattering. Leveraging this programmable
crystal, we determined 28 … Show more
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