Abstract:Tumor-derived p53 mutants activate transcription from promoters of various growth-related genes. We tested whether this transactivation function of the mutant protein is sucient to induce tumorigenesis (`gain of function'). Tumor-derived mutant p53-281G transactivates the promoters of human epidermal growth factor receptor (EGFR) and human multiple drug resistance gene . To determine whether the C-terminal domain functions only as an oligomerization domain in mutant p53-mediated transactivation, we have replac… Show more
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