Hetero-nuclear NMR-based Metabolomics

Kikuchi, Jun; Hirayama, Takashi

doi:10.1007/3-540-29782-0_7

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…NMR spectra experiments were performed as described previously (Kikuchi and Hirayama 2006;Tian et al 2007 C chemical shifts were referenced to DSS. The spectra were processed using NMRPipe software package (Delaglio et al 1995).…”

Section: Nmr Experimentsmentioning

confidence: 99%

Metabolic movement upon abscisic acid and salicylic acid combined treatments

Okamoto

Tsuboi

Chikayama

et al. 2009

Plant Biotechnology

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Section: Nmr Experimentsmentioning

confidence: 99%

Metabolic movement upon abscisic acid and salicylic acid combined treatments

Okamoto

Tsuboi

Chikayama

et al. 2009

Plant Biotechnology

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“…Table 2. Comparison between NMR and MS spectroscopy for methods in metabolomics analysis (Kikuchi and Hirayama, 2006;Khoo and Al-Rubeai, 2007;Teng, 2013;Emwas et al, 2013).…”

Section: Metabolomics Approachmentioning

confidence: 99%

Quality control of herbal medicines in hyperlipidaemia: Metabolomics approach

Sajak¹,

Azlan²,

Abas³

et al. 2023

IFRJ

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Hyperlipidaemia is one of the essential public health risk factors that can cause other metabolic diseases such as cardiovascular diseases and diabetes. Dieting and healthy lifestyle have been among the primary approaches. However, medication is required to regulate the lipid profile in some instances. Therefore, there has been an increase in interest in using or integrating herbal medicine with modern medicine in treating hyperlipidaemia. Nonetheless, preparing standardised herbal extract or products has been one of the major challenges in the herbal industry. Standardising herbal extract or product (single plant-based or mixture of multiple herbs) is needed to ensure the quality, safety, and efficacy of the herbal maintained from batch to batch before it is released to the market. The present review thus evaluates several herbal plants with anti-hyperlipidaemic activities, quality control using chemical markers, and metabolomics application in herbal plants.

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“…To study the dynamic movement of metabolites, the stable isotope technique is an emerging method in which 1 H, 13 C, 15 N and 31 P nuclei are used to track metabolites by NMR spectroscopy . Compounds containing these labelled nuclei are used in the media for the culture of cell lines.…”

Section: Sample Preparation For Nmr Analysismentioning

confidence: 99%

Nuclear magnetic resonance (NMR)‐based metabolomics for cancer research

Ranjan

Sinha

2018

NMR in Biomedicine

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Nuclear magnetic resonance (NMR) has emerged as an effective tool in various spheres of biomedical research, amongst which metabolomics is an important method for the study of various types of disease. Metabolomics has proved its stronghold in cancer research by the development of different NMR methods over time for the study of metabolites, thus identifying key players in the aetiology of cancer. A plethora of one-dimensional and two-dimensional NMR experiments (in solids, semi-solids and solution phases) are utilized to obtain metabolic profiles of biofluids, cell extracts and tissue biopsy samples, which can further be subjected to statistical analysis. Any alteration in the assigned metabolite peaks gives an indication of changes in metabolic pathways. These defined changes demonstrate the utility of NMR in the early diagnosis of cancer and provide further measures to combat malignancy and its progression. This review provides a snapshot of the trending NMR techniques and the statistical analysis involved in the metabolomics of diseases, with emphasis on advances in NMR methodology developed for cancer research.

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Hetero-nuclear NMR-based Metabolomics

Cited by 4 publications

References 30 publications

Metabolic movement upon abscisic acid and salicylic acid combined treatments

Metabolic movement upon abscisic acid and salicylic acid combined treatments

Quality control of herbal medicines in hyperlipidaemia: Metabolomics approach

Nuclear magnetic resonance (NMR)‐based metabolomics for cancer research

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