Hesperidin nanoparticles for prostate cancer therapy: preparation, characterization and cytotoxic activity
Mohammad Amin Bakhshan,
Sanaz Sheikhzadeh,
Nowruz Delirezh
Abstract:Hesperidin, a phytochemical renowned for its therapeutic effects including anticancer, antioxidant, and anti-inflammatory properties, encounters a significant limitation in its application due to its low bioavailability and restricted solubility in water. To surmount these challenges, we employed a spontaneous emulsification method to produce hesperidin nanoparticles. These nanoparticles, averaging 197.2±2.8 nm, exhibited uniform dispersion (Polydispersity index (PDI): 0.13), a zeta potential (ZP) of -28 mV, e… Show more
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