Hesperidin loaded Zn2+@ SA/PCT nanocomposites inhibit the proliferation and induces the apoptosis in colon cancer cells (HCT116) through the enhancement of pro-apoptotic protein expressions

Yang, Zhen; Yang, Hongwei; Dong, Xinhua; Pu, Minglong; Ji, Feihong

doi:10.1016/j.jphotobiol.2019.111767

Cited by 19 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Next, we intersected the ferroptosis gene set obtained from FerrDb with the 19 genes and finally obtained the SLC2A1 gene (Figures 2(b) - 2(c) ). In previous studies, researchers used all-trans retinoic acid (ATRA) to treat different lung cancer cells and found that the most significant reduction in the transcription level of SLC2A1 was found in SLC2A1 and the genes in the same family, thus excluding other gene families [ 5 ]. Therefore, we determined that the SLC2A1 gene not only plays an important role in ferroptosis but also plays an indispensable role in autophagy in colon cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Colon cancer is the third most common malignant tumor in the world, the second most common cancer among females, and the third most common cancer among males, with 1.2 million new cases and more than 600,000 deaths. Survival rates have improved over the past three decades due to early detection, but the 5-year survival rate for patients diagnosed at a later stage of the disease is still only 14% [2][3][4][5]. Colon cancer remains a relatively di cult disease to treat, although advanced treatments are available which can improve survival rates for the disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methylation Drives SLC2A1 Transcription and Ferroptosis Process Decreasing Autophagy Pressure in Colon Cancer

Zou

Xie

et al. 2022

Journal of Oncology

View full text Add to dashboard Cite

Colon cancer is a common malignant tumor in the digestive tract, with relatively high rates of morbidity and mortality. It is the third most common type of tumor in the world. The effective treatment of advanced colon cancer is limited, so it is particularly important to study the new pathogenesis of colon cancer. Ferroptosis is a nonapoptotic regulated cell death mode driven by iron-dependent lipid peroxidation, a process which has been discovered in recent years. Autophagy involves lysosomal degradation pathways that promote or prevent cell death. High levels of autophagy are associated with ferroptosis, but a clear association has not yet been made between ferroptosis and autophagy in colon cancer. Through the analysis of transcriptome expression profiling data in colon cancer, we obtained the common upregulated genes and downregulated genes by recording the intersection of the differentially expressed genes in each dataset. Solute Carrier Family 2 Member 1 (SLC2A1) was identified by combining autophagy genes obtained from GeneCards and ferroptosis genes obtained from FerrDb. In order to explore the clinical significance and prognostic value of SLC2A1, we utilized massive databases to conduct an in-depth exploration of the methylation of SLC2A1, and we also investigated the differences in immune infiltration between tumor and normal tissues. We found that there are abundant methylation sites in SLC2A1 and that the methylation of SLC2A1 is correlated with the immunosuppression of tumor tissue. We discovered that during the induction of environmental factors, the transcription and methylation levels of SLC2A1 were greatly increased, autophagy and ferroptosis were inhibited, and the immune system was defective, resulting in a poor prognosis for patients. These results suggest that the autophagy and ferroptosis-related gene SLC2A1 is involved in the tumor immune regulation of colon cancer, and SLC2A1 may become a new therapeutic target for colon cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methylation Drives SLC2A1 Transcription and Ferroptosis Process Decreasing Autophagy Pressure in Colon Cancer

Zou

Xie

et al. 2022

Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…Zn 2+ is essential for innate and adaptive immune activation and proper function of innate and adaptive immune cells, including the cytotoxic activity of NK cells and T cells [ 133 ]. Taking advantage of the excellent bioavailability of encapsulated ionotropic drugs, hesperidin-loaded Zn 2+ @ sodium alginate/pectin (SA/PCT) nanocomposites were designed to inhibit the proliferation of colon carcinoma cells and induce apoptosis under in vitro conditions [ 134 ].…”

Section: Several Breakthroughs Of Nanometallic Materials In Cancer Im...mentioning

confidence: 99%

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Shen

Fang

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years. Graphical Abstract

show abstract

“…Tangeretin and 5-FU synergistically up-regulate P21 in HCT-116 cells, which in turn activates the P53-mediated DNA damage response and triggers apoptosis via the JNK pathway, suggesting that the combination of tangeretin and 5-FU suppresses the autophagy pathway, enabling cancer cells susceptible to oxidative stress-induced programmed cell death [ 146 ]. Inhibition of colon cancer by hesperidin involves multiple alterations, including caspase-3-mediated apoptosis, the autophagy program initiated by PI3K/Akt/GSK-3c and mTOR pathway and, down-regulation of NF-κB and its target molecules iNOS and COX-2 to attenuate oxidative stress and enhance antioxidants to fight tumor-induced inflammation [ 147 , 148 , 149 , 150 ]. The above phenomenon also occurred in naringin-treated CRC cells, where the suppression of the PI3K/AKT/mTOR pathway resulted in ameliorated abnormal proliferation and apoptosis [ 151 ].…”

Section: Inhibitory Effect Of Crp and Its Active Components On Cancermentioning

confidence: 99%

Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review

et al. 2022

View full text Add to dashboard Cite

Citri Reticulatae Pericarpium (CRP), also known as “chenpi”, is the most common qi-regulating drug in traditional Chinese medicine. It is often used to treat cough and indigestion, but in recent years, it has been found to have multi-faceted anti-cancer effects. This article reviews the pharmacology of CRP and the mechanism of the action of flavonoids, the key components of CRP, against cancers including breast cancer, lung cancer, prostate cancer, hepatic carcinoma, gastric cancer, colorectal cancer, esophageal cancer, cervical cancer, bladder cancer and other cancers with a high diagnosis rate. Finally, the specific roles of CRP in important phenotypes such as cell proliferation, apoptosis, autophagy and migration–invasion in cancer were analyzed, and the possible prospects and deficiencies of CRP as an anticancer agent were evaluated.

show abstract

Hesperidin loaded Zn2+@ SA/PCT nanocomposites inhibit the proliferation and induces the apoptosis in colon cancer cells (HCT116) through the enhancement of pro-apoptotic protein expressions

Cited by 19 publications

References 32 publications

Methylation Drives SLC2A1 Transcription and Ferroptosis Process Decreasing Autophagy Pressure in Colon Cancer

Methylation Drives SLC2A1 Transcription and Ferroptosis Process Decreasing Autophagy Pressure in Colon Cancer

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review

Contact Info

Product

Resources

About