Hesperidin-Loaded Solid Lipid Nanoparticles: Development and Physicochemical Properties Evaluation

Ferrari, Priscileila Colerato; Correia, Mariana Kossatz; Somer, Aloisi; Ribeiro, Maurício A.; Astrath, N. G. C.; Sato, Francielle; Novatski, Andressa

doi:10.1166/jnn.2019.16355

Cited by 14 publications

(4 citation statements)

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“…Once isolated EVs from Citrus limon juice, we characterized flavonoids, limonoids and lipids, and we found that among the identified compounds, LEVs contain hesperidin and eriocitrin, two flavonoids with well‐recognized beneficial properties 27,30,31 . The great interest in their use as anti‐inflammatory agents is paralleled to studies aimed at encapsulating these natural compounds in lipid structures to increase their stability and availability 43–45 . Since EVs are naturally occurring nanoparticles, they may represent an advantage in transporting biomolecules to target cells 46 .…”

Section: Discussionmentioning

confidence: 99%

“… 27 , 30 , 31 The great interest in their use as anti‐inflammatory agents is paralleled to studies aimed at encapsulating these natural compounds in lipid structures to increase their stability and availability. 43 , 44 , 45 Since EVs are naturally occurring nanoparticles, they may represent an advantage in transporting biomolecules to target cells. 46 Moreover, our data indicated that LEVs contain several flavonoids that simultaneously interact with target cells; their synergic or additive actions define EV biological properties.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

Raimondo

Urzì

Meraviglia

et al. 2022

J Cellular Molecular Medi

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Chronic inflammation is associated with the occurrence of several diseases. However, the side effects of anti‐inflammatory drugs prompt the identification of new therapeutic strategies. Plant‐derived extracellular vesicles (PDEVs) are gaining increasing interest in the scientific community for their biological properties. We isolated PDEVs from the juice of Citrus limon L. (LEVs) and characterized their flavonoid, limonoid and lipid contents through reversed‐phase high‐performance liquid chromatography coupled to electrospray ionization quadrupole time‐of‐flight mass spectrometry (RP‐HPLC–ESI‐Q‐TOF‐MS). To investigate whether LEVs have a protective role on the inflammatory process, murine and primary human macrophages were pre‐treated with LEVs for 24 h and then were stimulated with lipopolysaccharide (LPS). We found that pre‐treatment with LEVs decreased gene and protein expression of pro‐inflammatory cytokines, such as IL‐6, IL1‐β and TNF‐α, and reduced the nuclear translocation and phosphorylation of NF‐κB in LPS‐stimulated murine macrophages. The inhibition of NF‐κB activation was associated with the reduction in ERK1‐2 phosphorylation. Furthermore, the ability of LEVs to decrease pro‐inflammatory cytokines and increase anti‐inflammatory molecules was confirmed ex vivo in human primary T lymphocytes. In conclusion, we demonstrated that LEVs exert anti‐inflammatory effects both in vitro and ex vivo by inhibiting the ERK1‐2/NF‐κB signalling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

Raimondo

Urzì

Meraviglia

et al. 2022

J Cellular Molecular Medi

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“…Further to develop new targeting strategies Ferrari et al. 108 have developed Hesp-coated solid lipid nanoparticles and evaluated there various physiochemical properties for optimum-targeted delivery for the treatment of several disorders. Praveen Kumar et al.…”

Section: Synergistic Interaction Of Hesperidin With Different Compoundsmentioning

confidence: 99%

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

Aggarwal

Tuli

Thakral

et al. 2020

Exp Biol Med (Maywood)

131

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Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-spectrum applicability to prevent dreadful diseases such as cardiovascular disease, neurodegeneration, and cancer. The reported anticancer effects of hesperidin have been found to be associated with its anti-oxidant and anti-inflammatory activities. Hesperidin interacts with numerous recognized cellular targets and inhibits cancer cell proliferation by inducing apoptosis and cell cycle arrest. In addition, evidence has suggested its promising role in inhibiting tumor cell metastasis, angiogenesis, and chemoresistance. The present mini-review highlights the ongoing development to identify hesperidin targets in cancer. Furthermore, the potential of nano technology-based hesperidin combinations and delivery systems will also be discussed. Overall, this review highlights all the possible molecular targets affected by hesperidin in tumor cells on a single platform. Impact statement Experimental findings from numerous studies have demonstrated the anticancer effects of hesperidin (Hesp) to be associated with anti-oxidant and anti-inflammatory activities along with its potential role in inhibiting the tumor cell metastasis and angiogenesis. Additionally, Hesp can also reverse drug resistance of cancer cells, which make it a promising candidate to be used in combination with existing anti-cancer drugs. This review will be helpful for upcoming researchers and scientific community to find out complete capsular package about cancer drug targets of Hesp and its role in modulating various important hallmarks of cancer.

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“…Hesperidin stability during formulation and analysis is also an issue related to its sensitivity that can harm its therapeutic potential. Several nanocarrier techniques, like liposomes, solid lipid nanoparticles (Ferrari et al, 2019), nanoemulsions (Somasundaram et al, 2018, and nanoparticles have been studied to overcome these obstacles. The nanotransferosome (Yuan et al, 2022) is the most useful vesicular system among these nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of stability indicating RP-HPLC method for estimation of hesperidin in nanotransferosome and Madhiphala rasayana—An Ayurvedic marketed product

Chimagave¹,

Jalalpure²,

Patil³

et al. 2022

J App Pharm Sc

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Hesperidin (4′-methoxy3′,5,7-trihydroxy flavanone) is a bioflavonoid molecule with remarkable wound healing properties as well as anticancer, antibacterial, antidiabetic, hepatoprotective, anti-inflammatory, and chemoprevention action. As a result, the current study used a stability-indicated reverse phase-high performance liquid chromatography (RP-HPLC) approach to synthesize and analyze hesperidin nanotransferosome. The important elements of the RP-HPLC method for hesperidin-based nanotransferosome stability highlighted were the retention time of 5.45 minutes, the limit of detection (LOD) of 0.008 μg/ml, the limit of quantification (LOQ) of 0.024 μg/ml, and the % relative standard deviation (RSD) of less than 2%. Hesperidin-loaded nanotransferosome were successfully demonstrated using the current RP-HPLC method, which has been proven to be stable. All vital factors, such as accuracy, linearity, LOD, LOQ, precision, and % RSD, were within the appropriate limits. Hesperidin was successfully quantified and estimated using the specified RP-HPLC method, and hesperidin-based nano transferosome confirmed hesperidin stability. This approach will be vital in evaluating the presence of hesperidin-containing therapeutic formulations.

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Hesperidin-Loaded Solid Lipid Nanoparticles: Development and Physicochemical Properties Evaluation

Cited by 14 publications

References 1 publication

Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

Development and validation of stability indicating RP-HPLC method for estimation of hesperidin in nanotransferosome and Madhiphala rasayana—An Ayurvedic marketed product

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