Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways

Zhao, Jun; Li, Yali; Gao, Jinfang; De, Yinshan

doi:10.3892/ol.2017.6873

Cited by 23 publications

(16 citation statements)

References 37 publications

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“…Hesperidin was also proved to inhibit ovarian cancer cell viability and increase cytotoxicity in a dose- and time-dependent manner. The mechanism of action involved induction of apoptosis through activation of protein expression of antigrowth arrest- and DNA damage-inducible gene 153, anti-CCAAT’enhancer-binding protein homologous protein, glucose-regulated protein 78, and cytochrome c. This mechanism may shed new light on a potential role of this dietary flavonoid in the prediction of ovarian carcinoma [121].…”

Section: Dietary Polyphenols—natural Substances Beneficial In the mentioning

confidence: 99%

Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review

2019

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The improvement of the social and economic conditions of society has eliminated the threat of death from the majority of infectious diseases. However, the rapid progress of civilization has created new possibilities for the appearance of factors with adverse effects for the health of society. This has led to increased morbidity from certain diseases, the presence of which had not been observed several centuries ago. Chronic noncommunicable diseases (e.g., cancers, cardio-vascular disorders, diabetes, obesity, neurodegenerative diseases) result from an inappropriate relationship between people and their environment. The common characteristic for all chronic diseases is a “new” form of inflammation, very often called metaflammation, which is considered as a subclinical, permanent inflammation. As a result, metabolic cascade, including cellular oxidative stress, atherosclerotic process, and insulin resistance, occurs, which slowly generates significant deterioration in the organism. Polyphenols are the major group of non-nutrients, considering their diversity, food occurrence, and biological properties. The current review aims to present a wide spectrum of literature data, including the molecular mechanism of their activity and experimental model used, and summarize the recent findings on the multitude of physiological effects of dietary polyphenols towards the prevention of several chronic diseases. However, despite several studies, the estimation of their dietary intake is troublesome and inconclusive, which will be also discussed.

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Section: Dietary Polyphenols—natural Substances Beneficial In the mentioning

confidence: 99%

Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review

2019

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“…The findings of the study revealed that hesperidin and neohesperidin notably aggravated indomethacin-induced gastric damage as evidenced by increased ulcer index and histopathological alteration [ 93 ]. Recently, hesperidin showed strong inhibition against ovarian cancer cell viability and caused apoptosis mediated through endoplasmic reticulum stress signaling pathways [ 94 ]. Hafidh et al [ 95 ] observed the potent anticancer effects of limonene in hepatocellular carcinoma and HepG2, and the cell line caused the modulation of cancer-inducing genes.…”

Section: Pharmacological Profilementioning

confidence: 99%

An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent

Süntar

Khan

Patel

et al. 2018

Oxidative Medicine and Cellular Longevity

122

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Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological effects and great variation in chemical composition depending on growing locations but mostly contained limonene, linalool, and β-myrcene. Phytochemically, C. aurantium is rich in p-synephrine, an alkaloid, and many health-giving secondary metabolites such as flavonoids. Animal studies have demonstrated a low affinity of p-synephrine for adrenergic receptors and an even lower affinity in human models. The present review focuses on the different biological activities of the C. aurantium in animal and human models in the form of extract and its pure secondary metabolites. Finally, it is concluded that both the extract and isolated compounds have no unwanted effects in human at therapeutic doses and, therefore, can confidently be used in various dietary formulations.

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“…[ 49 ] In this sense, several studies in cancer models have shown that hesperidin can delay cell proliferation, [ 50 ] inhibit cell viability, and induce apoptosis in cancer cells. [ 51 ] Therefore, studies of hesperidin supplementation in rats with cancer and its effects on the proteome are needed to provide more robust evidence and to clarify whether hesperidin could be a tumor suppressor.…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

Pla‐Pagà

Guirro

Gual‐Grau

et al. 2020

Molecular Nutrition Food Res

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Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg −1 day −1 ), MS rats without HS, and MS rats administered with HS (100 mg kg −1 day −1 ) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.

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Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways

Cited by 23 publications

References 37 publications

Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review

Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review

An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

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