Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells

Choi, In Young; Kim, Su Jin; Jeong, Hyun Ja; Park, Seong Heak; Song, Yong Sun; Lee, Ji Hyun; Kang, Tae Hee; Park, Jin Han; Hwang, Gab Soo; Lee, Eon Jeong; Hong, Seongin; Kim, Hyung Min; Um, Jae Young

doi:10.1007/s11010-007-9539-x

Cited by 67 publications

(42 citation statements)

References 41 publications

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“…In a study by Xiaoting et al, 8 hesperidin was able protect the retinal cells by inhibiting nitric oxide production, through inducible nitric oxide synthase inhibition. Recent studies also demonstrate their antiangiogenic activity through the inhibition of the expression of platelet-endothelial cell adhesion molecule-1 9 and hypoxia-inducible factor-1a, 10 which have been implicated in vasculogenesis and angiogenesis. Additionally, hesperidin and hesperetin demonstrate strong antioxidant properties.…”

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confidence: 99%

Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

Srirangam

Hippalgaonkar

Avula

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The objective of this study was to determine the ocular bioavailability of hesperidin and hesperetin, especially with respect to their distribution into the posterior segment of the eye, following systemic and topical administration in rabbits. Methods: Hesperidin and hesperetin were administered either intravenously or topically to male New Zealand white (NZW) rabbits. Vitreous humor and plasma samples were collected after intravenous administration and analyzed to estimate the concentrations of the parent compounds and their metabolites. Ocular tissue concentrations, obtained on topical administration of hesperidin and hesperetin, were also determined. Results: In the systemic circulation, hesperidin and hesperetin were rapidly metabolized into their glucuronides, which are extremely hydrophilic in nature. Vitreal samples did not demonstrate any detectable levels of hesperidin/hesperetin following intravenous administration. Topical administration produced significant concentrations of hesperidin/hesperetin in all the ocular tissues tested at the 1 and 3 hours time points postdosing, with hesperetin showing higher levels compared to hesperidin. However, only low levels were generated in the vitreous humor. Inclusion of a penetration enhancer, benzalkonium chloride (BAK), improved the back-ofthe-eye hesperetin levels. Conclusions: Ocular delivery of hesperidin/hesperetin via the systemic route does not seem to be feasible considering the rapid generation of the hydrophilic metabolites. Topical application appears to be more promising and needs to be further developed/refined.

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confidence: 99%

Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

Srirangam

Hippalgaonkar

Avula

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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“…Choi et al [27] reported that hesperidin reduced the expression of TNF-α by suppressing HIF-1α in mast cells. TNF-α is released from mast cells by degranulation and aggravates allergic symptoms by inducing neutrophil chemotaxis and the production of other inflammatory cytokines [28,29,30].…”

Section: Discussionmentioning

confidence: 99%

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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Background: Anaphylaxis is associated with systemic vasodilation that causes low blood pressure and induces hypoxic brain damage. The sound of a Buk (Korean traditional drum) is similar to the human heart beat and affects blood pressure, heart rate, and the nervous system by increasing physiological excitation and sympathetic nervous system activity. So, this study focused on the effect of Buk music as a means of treating anaphylaxis. Methods: Mice were given an intraperitoneal injection of compound 48/80 (6.5 mg/kg, a mast cell degranulator). After compound 48/80 injection, mice were exposed to Buk music and white noise for 5 min in a sound isolation booth. The mortality rate was checked over the next 40 min. Levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the serum and brain tissues were analyzed by Western blotting, quantitative real-time PCR, and ELISA methods. Results: Exposure to Buk music significantly reduced compound 48/80-induced mortality and histamine release, as well as HIF-1α and VEGF levels compared with the compound 48/80 group or compound 48/80 and white noise group. Buk music also reduced levels of tumor necrosis factor-α, and significantly increased estrogen receptor-β mRNA levels. Conclusion: These results indicate that Buk music has potential for the treatment of anaphylaxis.

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“…Citrus unshiu is minister medicinal of KMP6 as called 'Jinpi' in Korea. Citrus unshiu has many ingredients such as hesperidin, limonene, naringin, nobiletin, b-sitosterol, stigmasterol, Terpinen-4-ol, and vitamin C. Hesperidin (approximately 4.5 -10%), a main component of Citrus unshiu, has been reported to exhibit anti-inflammatory and antioxidant effects (Arafa et al, 2009;Choi et al, 2007). In addition, previous studies have revealed that citrus flavonoids such as naringin and nobiletin were found in anti-cancer, cardiovascular and anti-inflammatory activities (Benavente-García et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…The activation of MAPK induced TSLP expression (Choi et al, 2007). To determine the effect of KMP6 and hesperidin on MAPK activation induced by PMACI, Western blot analysis for phosphorylated p38 and JNK was performed.…”

Section: Effect Of Kmp6 On Mapk Phosphorylation In Hmc-1 Cellsmentioning

confidence: 99%

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

Song¹,

Nam²,

Choi³

et al. 2012

TANG [HUMANITAS MEDICINE]

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The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

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Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells

Cited by 67 publications

References 41 publications

Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

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