Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury

Kosari‐Nasab, Morteza; Shokouhi, Ghaffar; Ghorbanihaghjo, Amir; Abbasi, Mehran Mesgari; Salari, Ali-Akbar

doi:10.1016/j.lfs.2018.10.040

Cited by 49 publications

(29 citation statements)

References 58 publications

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“…The effect of hesperidin on depression‐like behavior is in accordance with previous reports. [ 42 ] Reversal of protective effect of hesperidin with concomitant administration of BADGE on depression‐like behavior suggests the possible involvement of PPAR‐γ receptor.…”

Section: Discussionmentioning

confidence: 99%

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Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

Jaiswal

Mandal

Mishra

2020

J Biochem & Molecular Tox

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Fluoride is the second largest contaminant of drinking water. Fluoride toxicity is a major concern in the endemic areas where a high amount of fluoride is present in ground water. Oxidative stress has been proposed to be one of the mechanisms of fluoride‐induced toxicity. Antioxidant‐rich food has been found to alleviate fluoride‐induced toxicity. Therefore, in this study, we have examined the effect of hesperidin on fluoride‐induced neurobehavioral changes in rats. In the current study, male Sprague‐Dawley rats were exposed to sodium fluoride through drinking water (120 ppm). Hesperidin (200 mg kg−1 d−1; per os) was administered either alone or in combination with fluoride‐containing drinking water. Bisphinol A diglycidyl ether (BADGE) was used as peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) antagonist and was administered (10 mg kg−1 d−1; intraperitoneal injection) with/without hesperidin along with fluoride‐containing drinking water. The behavioral changes in the animals were assessed by analyzing rotarod test, novel object recognition test, and forced swim test (FST). After 8 weeks, animals were killed to isolate blood and brain for monitoring biochemical changes. The 8‐week exposure of fluoride resulted in motor impairment as observed with reduced fall time in rotarod test, memory impairment as observed with reduced preference index in novel object recognition test, and depression‐like behavior as observed with reduced mobility index in the FST. Treatment with hesperidin improved neurobehavioral impairment along with restoration in brain biochemical changes (ie, acetylcholinesterase activity and antioxidant and oxidative stress parameters). The protective effect of hesperidin was reversed by coadministration of BADGE. The neuroprotective effect of hesperidin appears to be contributed through PPAR‐γ receptor.

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Section: Discussionmentioning

confidence: 99%

“…The observation with hesperidin is in accordance with previous literature suggesting its antioxidant potential in vivo. [ 42,54,55 ]…”

Section: Discussionmentioning

confidence: 99%

Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

Jaiswal

Mandal

Mishra

2020

J Biochem & Molecular Tox

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“…Furthermore, hesperetin enhanced synaptic integrity, cognition and memory processes by increasing the levels p-CREB, postsynaptic density protein-95 (PSD-95) and syntaxin proteins [ 229 ] and naringenin decreased the acetylcholinesterase (AChe) activity [ 230 ]. Other mental stresses such as social defeat stress, depression and autistic-like behaviors can also be counteract with flavanones in rodent models [ 231 , 232 , 233 ]. Hesperidin and naringenin have demonstrated positive effects by increasing the resilience through a reduction in the levels of interleukins and corticosterone thus suppressing the chronic inflammation caused by kynurenine pathway related to depression [ 234 ] and inhibiting the AChe activity, the oxidative stress as well as neuroinflammation [ 235 ].…”

Section: Flavanonesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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“…A lot of studies also prove that hesperidin has an effect on depression (Antunes et al, 2016;Morteza et al, 2018;Morteza et al, 2018;Fu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

Xie

Liu

et al. 2020

Front. Pharmacol.

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There is increasing evidence showing that inflammation is associated with depression in humans. Hesperidin, a natural bioflavonoid, has performed excellent effects on depression. The aim of this research was to investigate the therapeutic effect of hesperidin on chronic unpredictable mild stress (CUMS)-induced rats. The sucrose preference test (SPT), forced swimming test (FST), and open field test (OFT) were performed to measure the depression-related symptoms. The enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of interleukin (IL)-1b, IL-6, and tumor necrosis factor (TNF)-a in the prefrontal cortex (PFC) of rats and cellular supernatant. PCR and Western blot were used to monitor the differences of NLRP3, caspase-1, ASC activation in the levels of genes and proteins in the PFC of rats and microglia. The activation of microglia was determined using immunofluorescence staining and flow cytometry assay. Our results show that hesperidin treatment significantly relieved depressive like behaviors in CUMS rats. In addition, hesperidin decreased the expression levels of IL-1b, IL-6, TNF-a, NLRP3, caspase-1, and ASC in the PFC and microglia. This study investigated that hesperidin treatment ameliorated CUMS-induced depression by suppressing microglia and inflammation.

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Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury

Cited by 49 publications

References 58 publications

Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

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