Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome

Prasatthong, Patoomporn; Meephat, Sariya; Rattanakanokchai, Siwayu; Bunbupha, Sarawoot; Prachaney, Parichat; Maneesai, Putcharawipa; Pakdeechote, Poungrat

doi:10.1007/s00394-020-02291-4

Cited by 20 publications

(13 citation statements)

References 55 publications

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“…In addition, the treatment with 500-mg hesperidin significantly reduced the plasma levels of C-reactive protein and serum amyloid A in individuals with MS (Homayouni et al, 2017). Moreover, hesperidin reduced symptoms of MS and improved cardiac function in HFDinduced MS in rats (Prasatthong et al, 2021). Indeed, treatment with hesperidin (15 or 30 mg/kg) ameliorated cardiac dysfunction and hypertrophy in rats, restored the insulin signaling pathway, and IRS/Akt/GLUT4 protein expression.…”

Section: Antibacterial Effectmentioning

confidence: 94%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Antibacterial Effectmentioning

confidence: 94%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…The suppression of AMPK and IRS-1/GLUT4 has been proven to be associated with dysregulated glucose and lipid metabolism in IR-related models [9][10][11]. Conversely, molecules that could upregulate IRS-1/GLUT4 signaling or activate AMPK always display great effects on IR [10,12,13].…”

Section: Introductionmentioning

confidence: 99%

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD‐Induced Insulin Resistance by Modulating IRS‐1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways

Jian

Ding

et al. 2021

Oxidative Medicine and Cellular Longevity

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Loquat (Eriobotrya japonica Lindl.), a subtropical fruit tree native to Asia, is not only known to be nutritive but also beneficial for the treatment of diabetes in the south of China. To expand its development, this study was undertaken concerning the potential therapeutic role of total sesquiterpene glycosides (TSGs) from loquat leaves in insulin resistance (IR), the major causative factor of type 2 diabetes mellitus (T2DM). Male C57BL/6 mice were fed on high-fat diet (HFD) to induce IR and then were given TSG by oral administration at 25 and 100 mg/kg/day, respectively. TSG notably improved metabolic parameters including body weight, serum glucose, and insulin levels and prevented hepatic injury. Moreover, inflammatory response and oxidative stress were found to be remarkably alleviated in IR mice with TSG supplement. Further research in liver of IR mice demonstrated that TSG repaired the signalings of insulin receptor substrate-1 (IRS-1)/glucose transporter member 4 (GLUT4) and AMP-activated protein kinase (AMPK), which improved glucose and lipid metabolism and prevented lipid accumulation in liver. It was also observed that TSG suppressed the expression of transient receptor potential vanilloid 1 (TRPV1), whereas the signaling pathway of sirtuin-6 (SIRT6)/nuclear factor erythroid 2-related factor 2 (Nrf2) was significantly promoted. Based on the results, the current study demonstrated that TSG from loquat leaves potentially ameliorated IR in vivo by enhancing IRS-1/GLUT4 signaling and AMPK activation and modulating TRPV1 and SIRT6/Nrf2 signaling pathways.

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“…In this context, it is interesting to note that good results have been obtained in clinical studies with the integration of orange juice, polyphenols and particularly with both hesperidin and quercetin, with antioxidant and antihypertensive effects, and by regulating glucose metabolism and lipid profiles. A recent experimental study showed that hesperidin (15 or 30 mg/kg) improved biochemical alterations and cardiac dysfunction in a high-fat diet-induced MetS model in rats [156].…”

Section: Comorbiditiesmentioning

confidence: 99%

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

Bellavite¹

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Food polyphenols constitute a large family of substances with beneficial properties in a large group of communicable and non-communicable diseases. These compounds support and improve the body’s defences against oxidative stress and are helpful in the prevention of pathologies related to metabolic syndrome. Furthermore, they exhibit anti-inflammatory, antiviral, and antimicrobial properties. This chapter draws attention to certain nutritional components such as hesperidin and quercetin, which are emerging as good candidates for a complementary beneficial effect in the case of diseases caused by viruses, including COVID-19. These nutraceuticals have a complex mechanism of action, which involves both cellular defence against oxidative stress and the modulation of inflammation, which although normally is a defence, repair and activation mechanism of the immune system, it can elude its controls and become a systemic and destructive pathology (cytokine storm, respiratory distress syndrome). Furthermore, recent in silico simulation tests suggest that both hesperidin and quercetin may interfere with SARS-CoV-2 by binding to cell receptors and the proteolytic enzymes involved in its replication. In addition to the inhibitory effects on the virus at cellular level, the two flavonoids can have indirect effects in respiratory infectious diseases as they prevent or improve metabolic and vascular comorbidities that can complicate the clinical course. This brief review focuses on biochemical and pharmacological mechanisms of action of polyphenols in the context of the revaluation of dietary approaches to the prevention and treatment of infectious diseases caused by viruses, with a special application to COVID-19.

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Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome

Cited by 20 publications

References 55 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD‐Induced Insulin Resistance by Modulating IRS‐1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

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