Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca2+-dependent myosin phosphorylation

Xiong, Yongjian; Chu, Hang; Lin, Yuan; Fang, Haisheng; Li, Yachan; Wang, Aiguo; Wang, Fujin; Chen, Dapeng; Wang, Jingyu

doi:10.1038/aps.2016.56

Cited by 24 publications

(12 citation statements)

References 35 publications

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“…Studies by ourselves and others showed that intestinal motility disorder is typically accompanied by infiltration of the multiple inflammatory cells not only in the manipulated intestinal segments but also in the distant unmanipulated gastrointestinal segments . And an increase in the expression of several proinflammatory cytokines and chemokines is commonly present in this case . Furthermore, it is well‐known that there is a strong relationship between inflammation and gut barrier (GB) dysfunction.…”

Section: Introductionmentioning

confidence: 96%

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Lin

Zhang

Shen

et al. 2018

Neurogastroenterology Motil

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Section: Introductionmentioning

confidence: 96%

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Lin

Zhang

Shen

et al. 2018

Neurogastroenterology Motil

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“…MLCK protein expression in jejuna of constipated rats was examined using western blot as described previously [ 16 ]. Ardipusilloside-I at doses of 25, 50, 100 mg/kg was gavaged to constipated rats daily respectively as mentioned above.…”

Section: Methodsmentioning

confidence: 99%

Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase

Liang

Zhang

et al. 2017

Korean J Physiol Pharmacol

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Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in vitro and in vivo. The experiment of smooth muscle contraction directly monitored the contractions of the isolated jejunal segment (IJS) in different contractile states, and the effects of ardipusilloside-I on myosin were measured in the presence of Ca2+-calmodulin using the activities of 20 kDa myosin light chain (MLC20) phosphorylation and myosin Mg2+-ATPase. The effects of ardipusilloside-I on gastro emptying and intestinal transit in constipation-predominant rats were observed, and the MLCK expression in jejuna of constipated rats was determined by western blot. The results showed that, ardipusilloside-I increased the contractility of IJS in a dose-dependent manner and reversed the low contractile state (LCS) of IJS induced by low Ca2+, adrenaline, and atropine respectively. There were synergistic effects on contractivity of IJS between ardipusilloside-I and ACh, high Ca2+, and histamine, respectively. Ardipusilloside-I could stimulate the phosphorylation of MLC20 and Mg2+-ATPase activities of Ca2+- dependent phosphorylated myosin. Ardipusilloside-I also stimulated the gastric emptying and intestinal transit in normal and constipated rats in vivo, respectively, and increased the MLCK expression in the jejuna of constipation-predominant rats. Briefly, the findings demonstrated that ardipusilloside-I could effectively excite gastrointestinal motility in vitro and in vivo.

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“…Those rats that were supplemented with doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg prior to lipopolysaccharide-induced endotoxicity showed an improvement in endothelial status with respect to those that were not treated [ 38 ]. The capacity of hesperidin to down-regulate inflammatory status has been reported to improve rat postoperative ileus in a dose-dependent manner between 5 and 80 mg/kg [ 39 ]. A dose of 160 mg/kg in rats reduced lipid peroxidation and improved the activity of endogenous antioxidant enzymes, palliating effects of rheumatoid arthritis [ 40 ].…”

Section: Natural Extracts and Compounds With Anti-inflammatory Promentioning

confidence: 99%

Bioactive Compounds and Extracts from Traditional Herbs and Their Potential Anti-Inflammatory Health Effects

Serrano,

Ros,

Nieto

2018

Medicines

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The inflammatory processes associated with several chronic illnesses like cardiovascular disease and cancer have been the focus of mechanistic studies of the pathogenicity of these diseases and of the use of different pharmacological and natural methods to prevent them. In this study we review the current evidence regarding the effectiveness of natural extracts from as-yet little-studied traditional botanical species in alleviating the inflammation process associated with several chronic diseases. Additionally, the intention is to expose the known pathways of action and the potential synergistic effects of the constituent compounds of the discussed extracts. It is noted that the here-studied extracts, which include black garlic rich in S-allylcystein, polyphenols from cat’s claw (Uncaria tomentosa), devil’s claw (Harpagophytum procumbens), camu-camu (Myrciaria dubia), and blackcurrant (Ribes nigrum), and citrus fruit extracts rich in hesperidin, have similar or greater effects than other, more extensively studied extracts such as tea and cocoa. The combined use of all of these extracts can give rise to synergetic effects with greater biological relevance at lower doses.

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Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca2+-dependent myosin phosphorylation

Abstract: Oral administration of hesperidin effectively alleviates rat POI through inhibition of inflammatory responses and stimulation of Ca(2+)-dependent MLC phosphorylation.

Cited by 24 publications

References 35 publications

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase

Bioactive Compounds and Extracts from Traditional Herbs and Their Potential Anti-Inflammatory Health Effects

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