Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice

Jing, Shangwen; Wang, Xinyue; Zhang, Zerong; Cao, Deliang; Huang, Kaixun; Wang, Y G; Liu, Z.G.; Su, Shijie; Wang, Qi

doi:10.1007/s11011-023-01250-2

Cited by 8 publications

(5 citation statements)

References 51 publications

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“…Therefore, the capability of Citrus flavonoids to counteract inflammatory proce was observed to occur through a modulation of SIRT6. Along this line, LU suppresse vitro TNF-α-induced inflammatory injury and senescence via the SIRT6/NF-κB [189] support the well-known anti-inflammatory effects of HSP, Jing and co-workers sugges that it counteracts neuro-inflammation in vivo, by mitigating oxidative stress SIRT6/NLRP3 in mice [190]. In the same field, the CAPE appeared to play a key rol neurological complication after anesthesia and surgery though a mechanism involv SIRT6/Nrf2 activation, reducing oxidative stress and favoring microglia-protec Structurally, You and colleagues reported that QUE-based compounds activate as well as inhibit SIRT6 through the isoform-specific binding site for pyrrolo[1,2-a]quinoxalines, which can be considered as a versatile allosteric site for the modulation of SIRT6 [187].…”

Section: Sirt6mentioning

confidence: 84%

“…Along this line, LU suppressed in vitro TNF-α-induced inflammatory injury and senescence via the SIRT6/NF-κB [189]. To support the well-known anti-inflammatory effects of HSP, Jing and co-workers suggested that it counteracts neuro-inflammation in vivo, by mitigating oxidative stress via SIRT6/NLRP3 in mice [190]. In the same field, the CAPE appeared to play a key role in neurological complication after anesthesia and surgery though a mechanism involving SIRT6/Nrf2 activation, reducing oxidative stress and favoring microglia-protective polarization [191].…”

Section: Sirt6mentioning

confidence: 92%

“…Mitigation of diabetic inflammation through the modulation of TLR/MyD88/NF-κB signaling pathways, increasing SIRT6 expression [158] THP-1 cells LU/FIS Inhibition of ROS production through the elevation of SIRT6 and FOXO3a expression [159] Enzymatic assay/U2OS cells QUE, LU Modulation of SIRT6 activity [187] HUVEC cells ISL Decrease in vascular endothelial cell pyroptosis via the upregulation of SIRT6 [188] HNPC cells LU Anti-inflammatory effect by upregulating SIRT6 and hindering the downstream activation of NF-κB pathway [189] C57BL/6J mice HSP Counteraction of neuroinflammation and oxidative stress by increasing SIRT6 levels [190] C57BL/6J mice/BV2 cells CAPE Mitigation of post-operative cognitive dysfunction, hindering oxidative stress by enhancing the SIRT6/Nrf2 pathway [191] C57BL/6 mice/Human HEK-293T and mouse HT-22 cells FA Reduction in depression-like behaviors by suppressing AKT/CRMP2 and acting as downregulator of SIRT6 [192] Caffeic acid phenethyl ester (CAPE), ferulic acid (FA), fisetin (FIS), hesperetin (H isoliquiritigenin (ISL), luteolin (LU), quercetin (QUE).…”

Section: Thp-1 Cells Hspmentioning

confidence: 99%

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Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Lombardo,

Russo,

Maugeri

et al. 2024

IJMS

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Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer. Nowadays, it is well-known that Citrus fruits, typical of the Mediterranean diet, are an important source of bioactive compounds, such as polyphenols. Among these, flavonoids are recognized as potential agents endowed with a wide range of beneficial properties, including antioxidant, anti-inflammatory, hypolipidemic, and antitumoral ones. On these bases, we offer a comprehensive overview on biological effects exerted by Citrus flavonoids via targeting SIRTs, which acted as modulator of several signaling pathways. According to the reported studies, Citrus flavonoids appear to be promising SIRT modulators in many different pathologies, a role which might be potentially evaluated in future therapies, along with encouraging the study of those SIRT members which still lack proper evidence on their support.

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Section: Sirt6mentioning

confidence: 84%

Section: Sirt6mentioning

confidence: 92%

Section: Thp-1 Cells Hspmentioning

confidence: 99%

See 1 more Smart Citation

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Lombardo,

Russo,

Maugeri

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…According to the previous study, 23 the novel object recognition test was performed to assess the memory function in mice. The test comprised adaptation, familiarization, and test phases.…”

Section: Methodsmentioning

confidence: 99%

Identification of differential m6A RNA methylomes and ALKBH5 as a potential prevention target in the developmental neurotoxicity induced by multiple sevoflurane exposures

Meng,

Wang,

Zhao

et al. 2024

The FASEB Journal

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Sevoflurane, as a commonly used inhaled anesthetic for pediatric patients, has been reported that multiple sevoflurane exposures are associated with a greater risk of developing neurocognitive disorder. N6‐Methyladenosine (m6A), as the most common mRNA modification in eukaryotes, has emerged as a crucial regulator of brain function in processes involving synaptic plasticity, learning and memory, and neurodevelopment. Nevertheless, the relevance of m6A RNA methylation in the multiple sevoflurane exposure‐induced developmental neurotoxicity remains mostly elusive. Herein, we evaluated the genome‐wide m6A RNA modification and gene expression in hippocampus of mice that received with multiple sevoflurane exposures using m6A‐sequencing (m6A‐seq) and RNA‐sequencing (RNA‐seq). We discovered 19 genes with differences in the m6A methylated modification and differential expression in the hippocampus. Among these genes, we determined that a total of nine differential expressed genes may be closely associated with the occurrence of developmental neurotoxicity induced by multiple sevoflurane exposures. We further found that the alkB homolog 5 (ALKBH5), but not methyltransferase‐like 3 (METTL3) and Wilms tumor 1‐associated protein (WTAP), were increased in the hippocampus of mice that received with multiple sevoflurane exposures. And the IOX1, as an inhibitor of ALKBH5, significantly improved the learning and memory defects and reduced neuronal damage in the hippocampus of mice induced by multiple sevoflurane exposures. The current study revealed the role of m6A methylated modification and m6A‐related regulators in sevoflurane‐induced cognitive impairment, which might provide a novel insight into identifying biomarkers and therapeutic strategies for inhaled anesthetic‐induced developmental neurotoxicity.

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“…The progression of neurodegenerative diseases is generally accompanied by mitochondrial dysfunction, which leads to the excessive generation of reactive oxygen species (ROS) and to oxidative stress in the central nervous system (CNS) [ 2 ]. ROS-mediated oxidative damage can lead to serious damage to cellular structures [ 3 ] and can enhance the release of proinflammatory mediator proteins, such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), these proteins can regulate the secretion of nitric oxide (NO) and prostaglandin E2 (PGE 2 ) [ 4 ], thus leading to neuroinflammation [ 5 ]. Microglia are crucial immune cells in neuroinflammation and change their phenotypic and function in response to environmental signals [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Liu,

Yoon,

Lee

et al. 2024

IJMS

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Lindera erythrocarpa, a flowering plant native to eastern Asia, has been reported to have neuroprotective activity. However, reports on the specific bioactive compounds in L. erythrocarpa are finite. The aim of this study was to investigate the anti-neuroinflammatory and neuroprotective effects of the compounds isolated from L. erythrocarpa. Dihydropashanone, a compound isolated from L. erythrocarpa extract, was found to have protected mouse hippocampus HT22 cells from glutamate-induced cell death. The antioxidant and anti-inflammatory properties of dihydropashanone in mouse microglial BV2 and HT22 cells were explored in this study. The results reveal that dihydropashanone inhibits lipopolysaccharide-induced inflammatory response and suppresses the activation of nuclear factor (NF)-κB in BV2 cells. In addition, dihydropashanone reduced the buildup of reactive oxygen species in HT22 cells and induced activation of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling pathway in BV2 and HT22 cells. Our results suggest that dihydropashanone reduces neuroinflammation by decreasing NF-κB activation in microglia cells and protects neurons from oxidative stress via the activation of the Nrf2/HO-1 pathway. Thus, our data suggest that dihydropashanone offers a broad range of applications in the treatment of neurodegenerative illnesses.

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Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice

Cited by 8 publications

References 51 publications

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Identification of differential m6A RNA methylomes and ALKBH5 as a potential prevention target in the developmental neurotoxicity induced by multiple sevoflurane exposures

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

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