Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4–MyD88–NF-κB signaling pathway

Wang, Naigang; Geng, Cuiping; Sun, Haiyun; Wang, Xia; Li, Fangmin; Liu, Xunchao

doi:10.1007/s12272-019-01200-6

Cited by 47 publications

(38 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current results showed that paeonol exerted anti‐inflammatory effects on IR testes by downregulating TNF‐α gene expression as well as IL‐1β and IL‐6 protein expression. Paeonol displayed the same anti‐inflammatory effects in monosodium urate‐induced arthritis in rats (Chen et al, 2019) and lipopolysaccharides‐induced acute lung injury in mice (Wang, Zhu, et al, 2019). Moreover, paeonol protected against endoplasmic reticulum stress‐associated inflammation in lead‐stimulated kidneys (Liu et al, 2018) and IL‐1β‐induced inflammatory response in human primary chondrocytes (Wang, Xu, Kang, Zhang, & Li, 2019).…”

Section: Discussionmentioning

confidence: 91%

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

et al. 2020

View full text Add to dashboard Cite

Ischaemia‐reperfusion (IR) is the most common form of testicular injury that results in oxidative damage and inflammation ending by subinfertility. Paeonol, a natural phenolic compound, exhibits antioxidant and anti‐inflammatory effects. Thus, the present study investigated the role of paeonol in rat testicular IR injury. Thirty adult Wistar rats were randomly divided into five groups; sham, sham treated with paeonol, IR injury, and IR pre‐treated with paeonol at low and high doses. Serum testosterone and testicular levels of malondialdehyde and reduced glutathione (GSH) besides superoxide dismutase (SOD) activity were determined. Gene quantifications for tumour necrosis factor‐α (TNF‐α), hypoxia‐inducible factor‐1α (HIF‐1α) and heat shock protein 70 (HSP70) were also assessed. Histopathological pictures and the immunohistochemical expression of testicular nuclear factor erythroid 2‐related factor 2 (Nrf2), interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) were shown. Pre‐treatment with paeonol prevented the drop in serum testosterone, alongside with improvement of testicular malondialdehyde and GSH levels plus SOD activity. Paeonol regained the normal spermatogenesis with prevention of IR‐induced increase in TNF‐α, HIF‐1α and HSP70 gene expression besides IL‐1β and IL‐6 immunostaining and reduction in Nrf2 protein expression. Paeonol exerted a dose‐dependent beneficial effect on testicular IR injury. This effect was achieved by its antioxidant and anti‐inflammatory effects.

show abstract

Section: Discussionmentioning

confidence: 91%

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hespertein plus naringenin has a protective capacity against lung fibrosis by reducing airway inflammation in murine chronic asthma model. In addition, the anti-fibrotic effects of hespertein have been indicated in the liver and kidney [155,156]. Hespertin exerted inhibitory effect on the intracellular replication of transmitted Chikungunya virus (CHIKV) and exhibits drug-like properties which maybe a potential as a therapeutic option for CHIKV infection [157].…”

Section: Hesperetinmentioning

confidence: 99%

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Khalil

Tazeddinova

2020

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Polyphenols are a large family of more than 10,000 naturally occurring compounds, which exert countless pharmacological, biological and physiological benefits for human health including several chronic diseases such as cancer, diabetes, cardiovascular, and neurological diseases. Their role in traditional medicine, such as the use of a wide range of remedial herbs (thyme, oregano, rosemary, sage, mint, basil), has been well and long known for treating common respiratory problems and cold infections. This review reports on the most highlighted polyphenolic compounds present in up to date literature and their specific antiviral perceptive properties that might enhance the body immunity facing COVID-19, and other viral infectious diseases. In fact, several studies and clinical trials increasingly proved the role of polyphenols in controlling numerous human pathogens including SARS and MERS, which are quite similar to COVID-19 through the enhancement of host immune response against viral infections by different biological mechanisms. Thus, polyphenols ought to be considered as a potential and valuable source for designing new drugs that could be used effectively in the combat against COVID‐19 and other rigorous diseases.

show abstract

“…Relative expression of TLR4 mRNA 0 [55] and IL-1β-induced human fibroblast-like synoviocyte rheumatoid arthritis [56]. Stimulation of TLR4 produces the activation of NF-κB, which induces the generation of proinflammatory cytokines including TNF-α and IL-6 [17].…”

Section: Groupsmentioning

confidence: 99%

Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway

Al‐Taher

Morsy

Rifaai

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Methotrexate (MTX) is a commonly used chemotherapeutic agent. Oxidative stress and inflammation have been proved in the development of MTX toxicity. Paeonol is a natural phenolic compound with various pharmacological activities including antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of paeonol against MTX-induced cardiac toxicity in rats and to evaluate the various mechanisms that underlie this effect. Paeonol (100 mg/kg) was administered orally for 10 days. MTX cardiac toxicity was induced at the end of the fifth day of the experiment, with or without paeonol pretreatment. MTX-induced cardiac damage is evidenced by a distortion in the normal cardiac histological structure, with significant oxidative and nitrosative stress shown as a significant increase in NADPH oxidase-2, malondialdehyde, and nitric oxide levels along with a decrease in reduced glutathione concentration and superoxide dismutase activity compared to the control group. MTX-induced inflammatory effects are evidenced by the increased cardiac toll-like receptor 4 (TLR4) mRNA expression and protein level as well as increased cardiac tumor necrosis factor- (TNF-) α and interleukin- (IL-) 6 levels along with increased nuclear factor- (NF-) κB/p65 immunostaining. MTX increased apoptosis as shown by the upregulation of cardiac caspase 3 immunostaining. Paeonol was able to correct the oxidative and nitrosative stress as well as the inflammatory and apoptotic parameters and restore the normal histological structure compared to MTX alone. In conclusion, paeonol has a protective effect against MTX-induced cardiac toxicity through inhibiting oxidative and nitrosative stress and suppressing the TLR4/NF-κB/TNF-α/IL-6 inflammatory pathway, as well as causing an associated reduction in the proapoptotic marker, caspase 3.

show abstract

Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4–MyD88–NF-κB signaling pathway

Cited by 47 publications

References 30 publications

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway

Contact Info

Product

Resources

About