2003
DOI: 10.1128/mcb.23.19.6922-6935.2003
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Hes6 Promotes Cortical Neurogenesis and Inhibits Hes1 Transcription Repression Activity by Multiple Mechanisms

Abstract: Hes1 is a mammalian basic helix-loop-helix transcriptional repressor that inhibits neuronal differentiation together with corepressors of the Groucho (Gro)/Transducin-like Enhancer of split (TLE) family. The interaction of Hes1 with Gro/TLE is mediated by a WRPW tetrapeptide present in all Hairy/Enhancer of split (Hes) family members. In contrast to Hes1, the related protein Hes6 promotes neuronal differentiation. Little is known about the molecular mechanisms that underlie the neurogenic activity of Hes6. It … Show more

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Cited by 111 publications
(159 citation statements)
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“…Together, our experiments showed that, in contrast to what has been observed in other regions of the nervous system (Bae et al, 2000;Koyabi-Nakagawa et al, 2000;Gratton et al, 2003), Hes6 is not sufficient to induce the expression of hair cell-specific or neuronal-specific markers in the cochlear tissue culture. The elusive role of Hes6 in the inner ear may indicate the complexity and the redundancy of the regulation of inner ear development necessary to ensure the precise …”
Section: Potential Role Of Hes6 In Inner Ear Developmentcontrasting
confidence: 62%
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“…Together, our experiments showed that, in contrast to what has been observed in other regions of the nervous system (Bae et al, 2000;Koyabi-Nakagawa et al, 2000;Gratton et al, 2003), Hes6 is not sufficient to induce the expression of hair cell-specific or neuronal-specific markers in the cochlear tissue culture. The elusive role of Hes6 in the inner ear may indicate the complexity and the redundancy of the regulation of inner ear development necessary to ensure the precise …”
Section: Potential Role Of Hes6 In Inner Ear Developmentcontrasting
confidence: 62%
“…6), it is capable of promoting expression of neuronal genes in vitro, as well as expanding the myotome in Xenopus embryos (Bae et al, 2000;Koyabi-Nakagawa et al, 2000;Gao et al, 2001;Cossins et al, 2002;Gratton et al, 2003). It was further demonstrated that Hes6 antagonizes and releases the transcriptional repression of Hes1 in both the neuronal and muscle lineages to promote the expression of positively acting bHLH genes, or to promote the action of positively acting bHLH factors (Bae et al, 2000;Koyabi-Nakagawa et al, 2000;Gao et al, 2001;Cossins et al, 2002;Gratton et al, 2003). Of interest, Hes1 is expressed in the cochlear epithelium adjacent to the organ of Corti Zine et al, 2001), and the number of hair cells is increased in Hes1 knockout animals Zine et al, 2001).…”
Section: Hes6 Is Not Sufficient For Hair Cell Differentiation In Cochmentioning
confidence: 99%
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“…Coupling of angiogenesis and neurogenesis after stroke H Teng et al in the levels of Sox2 mRNA, a gene involved in the maintenance of neural progenitor cell identity (Bani-Yaghoub et al, 2006;Graham et al, 2003), and an increase in the levels of Hes6 mRNA, a gene that promotes neuronal differentiation but inhibits astrocyte differentiation (Gratton et al, 2003;Jhas et al, 2006) (Figure 3). However, when normal SVZ cells were cocultured with stroke RBECs in the growth or differentiation medium in the presence of SU1498, a VEGFR2 antagonist, the number of BrdU + (Figures 2C to E) and Tuj1 + ( Figures 2I, 2J, and 2O) cells was significantly reduced, while the number of GFAP + cells did not significantly change (26.8% ± 1.8% versus 23.5% ± 4.0% in the SU1498 group, Figures 2M, 2N, and 2P).…”
Section: Endothelial Cells Activated By Stroke Increase Proliferationmentioning
confidence: 99%