Herpetic trigeminal trophic syndrome in an infant

Lyon, C. C.; Mughal, M Z; Muston, Haydn L.

doi:10.1177/014107680109400311

Cited by 25 publications

(24 citation statements)

References 13 publications

(1 reference statement)

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“…6 The age of TTS presentation varies, with patients as young as 14 months and as old as 94 years. 6,7 However, the mean age of presentation is reported at 57, with a female predominance of 2.2 : 1. 6 This female preponderance corresponds to the presentation of trigeminal neuralgia, which also has a female predilection.…”

Section: Epidemiologymentioning

confidence: 99%

“…Yacoumettis et al 28 Ala nasi Ulcer Mishriki et al 31 Ala nasi Erosion Arasi et al 5 Ala nasi Erosion George et al 32 Ala nasi Ala nasi atrophy Thomas et al 33 Ala nasi Destruction of ala nasi Litschel et al 34 Ala nasi Lesion Ziccardi et al 27 Ala nasi Ulceration with peripheral inflamation Bauer 35 Ala nasi Ulcer Lyon et al 7 Ala nasi Crusting ulcer Goodnight et al 36 Ala nasi (2) Ulcer with erosion and crusting Tollefson et al 30 Ala nasi (5) Ulcer and erosion Monrad et al 4 Ala nasi, canthus Crusted ulcer and erosion Preston et al 29 Ala nasi (2), Cheek Ulcer Finlay et al 1 Ala nasi, cheek Ulcer with clean base Sadeghi et al 37 Ala nasi, cheek Expanding ulcer and inflammation Cheek, canthus Non-healing ulcer Ala nasi, cheek Ulcer and erosion Ala nasi, scalp, preauricular skin, tragus Ulcer, erosion, crusting, and serosanguinous drainage Tada et al 38 Ala nasi, forehead Deep ulceration and destruction. Spillane et al 8 Ala nasi (2), septum Ulcer and erosion Walton et al 39 Ala nasi (4), septum (2), upper lip Ulcer Owen et al 40 Ala nasi, septum Ulcer Weintraub et al 6 Ala nasi, upper lip, cheek One continuous lesion of a shallow well circumscribed ulcer with shallow bleeding base and erosion Loveman 3 Ala nasi, temple, forehead, angle of eye Carcinomatous-like ulcer and trophic ulcer Karnosh et al 41 Forehead, temple, lip, cheek, nose Well demarcated erythematous plaque Ala nasi, angle of the mouth, cheek, eyelid, chin Red patches of indurated crusted skin.…”

Section: Study Lesion Location (N) Descriptionmentioning

confidence: 99%

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Trigeminal trophic syndrome

Rashid

Khachemoune

2007

Acad Dermatol Venereol

136

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Trigeminal trophic syndrome (TTS) is a rare cause of facial ulceration, which is believed to develop after insult to the trigeminal ganglia or other parts of the peripheral/central nervous system in the trigeminal pathway. The pathogenesis of TTS is poorly understood. Developing a better understanding of TTS will allow early recognition and improved treatment. Although the ulcers develop predominantly on the ala nasi, the literature on ulcer locations is limited. In this article, we review the epidemiologic aspects of TTS, expand on our knowledge of the anatomic location of the ulcers, and discuss current theories for its aetiology and briefly review the approaches to its management.

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Section: Epidemiologymentioning

confidence: 99%

Section: Study Lesion Location (N) Descriptionmentioning

confidence: 99%

Trigeminal trophic syndrome

Rashid

Khachemoune

2007

Acad Dermatol Venereol

136

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“…Of these cases, 70% were iatrogenic and occurred as a complication after surgical treatment of trigeminal neuralgia. We reviewed another 21 additional cases of TTS [1,5,4,7,12,16,17,19,21,23,28] (Table 1). Twenty-seven cases were associated with injections of alcohol into the gasserian ganglion and four cases with electrocoagulation.…”

Section: R Litschel · H Winkler · S Dazert · H Sudhoffmentioning

confidence: 99%

“…The highest incidence of TTS was related to trigeminal rhizotomy (39 cases). However, if we leave out the youngest patient, a 14-month-old boy suspected to have TTS after herpes simplex labialis [12], the mean age increases to 64 years (range: 25 to 87 years). About 11% (11 cases) de-veloped after ischemic lesions in the trigeminal ganglion, e.g., stroke [6,14] or Wallenberg's syndrome [19].…”

Section: R Litschel · H Winkler · S Dazert · H Sudhoffmentioning

confidence: 99%

Herpes zoster-associated trigeminal trophic syndrome: a case report and review

Litschel

Winkler

Dazert

et al. 2003

Eur Arch Otorhinolaryngol

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The case of a 75-year-old Caucasian woman with a trigeminal trophic syndrome (TTS) is presented and discussed. TTS of the ala nasi subsequent to a herpes zoster infection has not been described previously. We provide a review of the literature with insights into the pathogenesis and current therapeutic strategies. Keywords Trigeminal trophic syndrome · Ala nasi lesion · Herpes zoster infection · ReviewCase report A 75-year-old Caucasian woman was referred to our department with a right ala nasi lesion (Fig. 1). She had a history of breast carcinoma, which had been treated with surgery and radio-chemotherapy. Three years ago, herpes zoster affected the second division of the right trigeminal nerve. Subsequently, the patient developed postherpetic neuralgia, which was treated with carbamazepine. The initial anterior rhinoscopy showed a small mucosal fissure of the right nasal ala. Treatment consisted of local application of polymyxin-B ointment. Three months later, the patient returned with a distinct lesion, which expanded within weeks and was associated with recurrent bleeding. The following physical examination revealed a crescent lesion of about 2 cm in length with a concomitant loss of a significant portion of the right ala nasi and a complete anesthesia of the maxillary dermatome. The patient complained about numbness, paresthesia and the psychosocial impact of the lesion. We ruled out a malignant lesion with biopsies, and computed tomography was performed (Fig. 2). Two biopsies from the remaining ala and the lateral nasal margin confirmed the lack of malignancy. Histopathologically, the hyperkeratotic epidermis did not have any irregularities or signs of malignant transformation. Considering the patient's history of herpes zoster in the same right maxillary dermatome and the persistence of anesthesia, we assumed a trophic malfunction, e.g., trigeminal trophic syndrome (TTS). To our knowledge, TTS of the ala nasi has not been previously reported subsequent to a herpes zoster infection. After a thorough assessment and review of the literature, we decided to Eur Arch Otorhinolaryngol (2003) 260 : 86-90

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“…4 Trigeminal trophic syndrome manifests itself as a unilateral crescent-shaped ulceration around the nasal ala, but in severe cases, there may be involvement of the jaw, forehead, cheek, and lip. We know of only 3 previously reported pediatric cases, [5][6][7] and, to our knowledge, TTS has never been successfully treated with a vacuum-dressing device.…”

Section: Commentmentioning

confidence: 99%

Successful Treatment of Trigeminal Trophic Syndrome in a 6-Year-Old Boy With Negative Pressure Wound Therapy

Fredeking¹

2008

Arch Dermatol

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Herpetic trigeminal trophic syndrome in an infant

Cited by 25 publications

References 13 publications

Trigeminal trophic syndrome

Trigeminal trophic syndrome

Herpes zoster-associated trigeminal trophic syndrome: a case report and review

Successful Treatment of Trigeminal Trophic Syndrome in a 6-Year-Old Boy With Negative Pressure Wound Therapy

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