Herpetic gingivostomatitis in a patient with COVID‐19: Is this mutual relationship possible?

Santana, Lucas Alves da Mota; Pinho, John Nadson Andrade; Oliveira, Eduardo Morato de; Lessa, A; Trento, Cléverson Luciano

doi:10.1111/ors.12609

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2023

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“…Nevertheless, it seems unusual for the patient to develop similar symptoms of HSV-1 as the second case. Both COVID-19-associated oral and gingival ulcer and inflammation (Wu et al 2021;da Mota et al 2021) and COVID-19-associated herpetic gingivostomatitis Kämmerer et al (2021) have been described. Disease course and MRI findings are compatible with our primary diagnosis in this case; however, HSV-I reactivation in the setting of SARS-CoV-2 infection might explain presence of HSV-I DNA in the CSF and encephalopathy symptoms.…”

Section: Discussionmentioning

confidence: 99%

Central nervous system reactivation of herpesviridae family in patients with COVID-19

et al. 2023

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The objective of this study is to describe our COVID-19 patients with herpesviridae reactivation in the central nervous system (CNS). Four patients were described including two with acute encephalitis and two with acute encephalomyelitis. Three of four patients had abnormal findings on neuroimaging studies. One of four patients died, one survived with major neurological sequelae, and two others fully recovered. Herpesviridae reactivation in the CNS in patients with COVID-19 is a rare but serious coincidence. The optimal therapeutic management has not been investigated and until more information is available, it is prudent to treat these patients with appropriate antivirals with or without anti-inflammatory agents.

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Section: Discussionmentioning

confidence: 99%