Herpesviruses

Mettenleiter, Thomas C.; Ehlers, Bernhard; Müller, Thomas; Yoon, Kyoung‐Jin; Teifke, Jens Peter

doi:10.1002/9781119350927.ch35

Cited by 25 publications

(55 citation statements)

References 173 publications

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“…Nearly all other mammals are also thought to be susceptible to the infection, except higher primates, but as dead end hosts (Spickler, ). It is difficult to infect horses and birds; large virus doses are necessary and they must be injected either intracerebrally, subcutaneously or intramuscularly (Mettenleiter et al., ). Higher primates, including humans, are considered non susceptible to the virus, in spite some clinical cases reported in humans (see Section 3.1.1.3).…”

Section: Assessmentmentioning

confidence: 99%

“…The pig ( S. scrofa ) (including wild boar or feral pigs) is the only species that serves as the reservoir host (Mettenleiter et al., ).…”

Section: Assessmentmentioning

confidence: 99%

“…In soil, infectious virus was recovered for 5–6 weeks. Virus dried on sacks and wood persisted for about 10 days in summer and 15 days in winter (Mettenleiter et al., ).…”

Section: Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Aujeszky's disease

More¹,

Bøtner²,

Butterworth

et al. 2017

EFS2

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Aujeszky's disease has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of Aujeszky's disease to be listed, Article 9 for the categorisation of Aujeszky's disease according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to Aujeszky's disease. The assessment has been performed following a methodology composed of information collection and compilation, expert judgement on each criterion at individual and, if no consensus was reached before, also at collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. Details on the methodology used for this assessment are explained in a separate opinion. According to the assessment performed, Aujeszky's disease can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL. The disease would comply with the criteria as in sections 4 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (d) and (e) of Article 9(1). The animal species to be listed for Aujeszky's disease according to Article 8(3) criteria are mainly the species of the family of Suidae as susceptible species, although almost all mammals can be infected, and Sus scrofa as reservoir species.

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Section: Assessmentmentioning

confidence: 99%

“…The pig ( S. scrofa ) (including wild boar or feral pigs) is the only species that serves as the reservoir host (Mettenleiter et al., ).…”

Section: Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Aujeszky's disease

More¹,

Bøtner²,

Butterworth

et al. 2017

EFS2

View full text Add to dashboard Cite

show abstract

“…Aujeszky's disease virus, like other herpesviruses, establishes lifetime infections in swine by inducing specific host cells in order to retain the viral genome (Mettenleiter, Ehlers, Müller, Yoon, & Teifke, ). This particular trait of the herpesviruses is known as viral latency (see Widén et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…This particular trait of the herpesviruses is known as viral latency (see Widén et al, ). Latency is established mainly in cells of nervous ganglia such as the trigeminal ganglia in the head and the sacral ganglia in the lumbar region (Mettenleiter et al, ; Romero, Meade, Homer, Shultz, & Lollis, ). ADV replication can reactivate from latently infected cells after the immune depression of the host or during periods of hormonal imbalance, for example gestation.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Aujeszky's disease virus infection in wild boar in enzootic scenarios

Casades‐Martí

González‐Barrio

Royo-Hernández

et al. 2019

Transbound Emerg Dis

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Aujeszky's disease (AD) virus is enzootic in Iberian wild boar, thus posing a threat to the official eradication of AD on extensive domestic pig farms in Spain. Understanding the dynamics and drivers of ADV infection in wild boar will help prevent viral transmission at the wild boar–pig interface. This study analyses the dynamics of ADV infection in wild boar and tests relevant hypotheses in order to identify drivers of ADV infection dynamics. Wild boar sera (N = 971) and oropharyngeal tonsils (TN, N = 549) collected over 11 consecutive years in south‐western Spain were tested for ADV antibodies and DNA, respectively. We tested the hypotheses that population immunity modulates the risk of ADV infection (H1) and that detecting ADV DNA in TN is a good proxy of the annual ADV infection pressure (H2). This was done by building logistic regression models that were subsequently employed to test the influence of a series of host population and host individual factors—including predictors of ADV immunity in the population—on the annual risk of new ADV infections and on the presence of ADV DNA in TN. The premise of H1 was that there would be a negative association between the proportion of ADV antibody‐positive wild boar in a given year and the risk of ADV infection of naïve individuals. There was, however, a positive association, and H1 was, therefore, rejected. If detecting ADV in TN had been a good indicator of ADV infection pressure, a positive association with the proportion of ADV antibody‐positive wild boar would have been found. However, this was not the case and H2 was also rejected. We confirmed that ADV infection is a dynamic phenomenon. The risk of infection with ADV can change considerably between consecutive years, and these changes are positively associated with the proportion of infected wild boar in the population.

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Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

Najafi

Tan

Aghamiri

et al. 2022

Biomedicine & Pharmacotherapy

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Herpesviruses

Cited by 25 publications

References 173 publications

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Aujeszky's disease

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Aujeszky's disease

Dynamics of Aujeszky's disease virus infection in wild boar in enzootic scenarios

Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

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