Herpesviruses excretion in saliva of pediatric transplant recipients

Sierra, C.; Cardellá, Vivian Kourí; Santos, Lissette Pérez; Silverio, César E.; Hondal, Norma; Florín, José

doi:10.1111/tid.12771

Cited by 6 publications

(9 citation statements)

References 32 publications

(36 reference statements)

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“…Although those authors suggest the existence of such a relationship, it is not causal. Moreover, they found no relationship between CMV viral load in saliva and active disease 17 . Immunosuppressive protocol, reduced sample size, pediatric patients, type of transplantation (renal and hepatic) and methodology techniques can explain the higher frequency of participants with CMV viremia compared to ours, that is, 37% versus 12%.…”

Section: Discussioncontrasting

confidence: 62%

“…A study with 27 pediatric kidney‐liver transplant patients reported that herpesviruses were detected in 88.9% and 37.0% of the samples of saliva and blood, respectively, with the majority (22/27) having more than one virus at the same time 17 . A similar pattern was also found in our study, but contrary to our results, those authors found a relationship between salivary excretion and CMV viremia.…”

Section: Discussioncontrasting

confidence: 54%

“…In fact, valganciclovir reduced the incidence of EBV from 61.3% to 17.8% as well as the amount of virus detected 29 . It was also reported that prophylaxis with ganciclovir for 1‐3 months after transplantation accounts for a significant reduction in the detection of CMV in saliva 17 …”

Section: Discussionmentioning

confidence: 94%

“…Our results showed that herpesviruses were co‐detected in the participants’ saliva before renal transplantation (32.8%) as well as 15‐20 (56.1%) and 45‐60 (52%) days after transplantation. In terms of prognosis of transplantation, the salivary shedding of several herpesviruses simultaneously and the association with active diseases are not well understood 13,14,17 . Association and high co‐circulation of herpesviruses in the saliva samples after transplantation may be the result of the opportunistic additive character of herpesviruses in association with trans‐activation, immunosuppression and modulation of cytokines from the use of immunosuppressive drugs 27,28 …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study

Sarmento

Tozetto‐Mendoza

Souza

et al. 2020

Transplant Infectious Dis

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Background The objective was to assess the oral shedding and viremia of human herpesviruses in renal transplant recipients. Methods This is a cohort study in which the participants were examined in three different periods: the first within 24 hours before renal transplantation and the second and third ones 15‐20 and 45‐60 days after the transplantation. Mouthwash and blood samples were collected in each period and then submitted to screening for the presence of eight types of human herpesviruses by using multiplex PCR. Results HSV‐1 and EBV were more frequent in the saliva after renal transplantation, 15‐ to 20‐day period after the transplant. EBV was found in the saliva of 26 (35.6%) patients before renal transplantation and in 56.2% and 46.6% of them, in the 15‐ to 20‐day and 45‐ to 60‐day periods after the transplant, respectively. High detection rates (75.3%‐78.1%) were found for HHV‐7 despite the lack of significant variations between the study periods. There was no concordance between herpesviruses oral shedding and viremia. Conclusion We concluded that the pattern of excretion of HSV‐1 and EBV in saliva is changed immediately after renal transplantation, increasing in the 15‐ to 20‐day period after the transplant surgery. No concordance between herpesviruses oral shedding and viremia was observed.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study

Sarmento

Tozetto‐Mendoza

Souza

et al. 2020

Transplant Infectious Dis

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“…Oral CMV DNA shedding is frequent in allo‐HSCT recipients and may precede the detection of CMV DNA in blood . Recently published data suggest that this may indeed be the case in pediatric solid organ transplant recipients, in which patients with CMV DNA detectable in their saliva are more likely to develop CMV DNAemia . Based on these studies, in addition to assessing the frequency of CMV DNA detection in saliva, we examined the kinetics of oral CMV DNA shedding and that of plasma CMV DNAemia in a cohort of allo‐HSCT and assessed to what extent serial screening of saliva specimens for the presence of CMV DNA by using a highly sensitive real‐time PCR would allow anticipation of the occurrence of plasma CMV DNAemia.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of oral cytomegalovirus DNA shedding for the prediction of viral DNAemia in allogeneic hematopoietic stem cell transplant recipients

Pascual

Solano

Torres

et al. 2018

Journal of Medical Virology

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Preemptive antiviral therapy based on detecting cytomegalovirus (CMV) DNAemia above a preestablished threshold is the mainstay strategy for the prevention of CMV disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients; nevertheless, CMV DNAemia, even at low levels, may increase mortality. We investigated whether surveillance of saliva for the presence of CMV DNA may anticipate the occurrence of CMV DNAemia. This was a prospective observational study with 53 consecutively enrolled allo-HSCT recipients. Saliva and plasma specimens were collected on a weekly basis from Day 0 to Day 100 after transplantation. CMV DNA was quantified in both specimen types using the Abbott Real-Time PCR assay (Abbott Molecular, Des Plaines, IL). CMV DNA was quantifiable in 44 (83%) patients: either in saliva (n = 1) or plasma (n = 12) only, or in both specimen types (n = 31). CMV oral shedding preceded the occurrence of CMV DNAemia in eight patients (18.2%), while the opposite pattern was observed in 21 patients (47.7%). The CMV DNA loads quantified in saliva and plasma correlated modestly (P = 0.33; P = 0.013) and did not differ in magnitude (P = 0.527). No transplantation factors, other than recipient CMV seropositivity, were associated with oral CMV DNA shedding; serum CMV IgG levels were comparable, regardless of the timing of the detection of CMV DNA at both sites. In summary, screening of saliva specimens for the presence of CMV DNA appear to be of limited value for anticipating the occurrence of CMV DNAemia in allo-HSCT recipients.

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Herpesviruses in the oral cavity of patients subjected to allogeneic hematopoietic stem cell transplantation and its relationship with oral mucositis

et al. 2020

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Objectives This study was performed to characterise oral shedding of herpesviruses in patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) and to investigate its relationship with oral mucositis (OM). Materials and Methods PCR and enzymatic digestion were conducted to identify oral shedding of herpesviruses and its correlation with OM development in 31 patients. The samples were collected at three sites in the oral cavity and at 5 times during follow-up; two additional collections were made from patients who developed ulcerative OM.

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Herpesviruses excretion in saliva of pediatric transplant recipients

Cited by 6 publications

References 32 publications

Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study

Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study

Monitoring of oral cytomegalovirus DNA shedding for the prediction of viral DNAemia in allogeneic hematopoietic stem cell transplant recipients

Herpesviruses in the oral cavity of patients subjected to allogeneic hematopoietic stem cell transplantation and its relationship with oral mucositis

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