Herpesvirus simplex Infection

Hunt, Ronald D.

doi:10.1007/978-3-642-84906-0_13

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Once brought into a colony, the disease spread rapidly and had high morbidity and mortality. 9 Because humans are the natural or reservoir host for the virus, contact with symptomatically and subclinically HHV-infected humans should always be avoided. Infected persons can excrete the virus even in the absence of visible lesions.…”

Section: Pathologymentioning

confidence: 99%

“…These lesions cannot be differentiated from herpesvirus T infection, which leads to a systemic infection with identical gross and microscopic lesions. 1,9 Herpes tamarinus (HVT) was originally isolated from moribund marmosets (tamarins) and owl monkeys. Squirrel monkeys are the natural host for this virus, 13 which is distantly related to the other primate herpesviruses (HHV-1, HHV-2, SA8, and B virus).…”

Section: Pathologymentioning

confidence: 99%

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Fatal Herpes simplex Infection in a Group of Common Marmosets (Callithrix jacchus)

Mätz‐Rensing¹,

Jentsch

Rensing³

et al. 2003

Vet Pathol

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Abstract. An outbreak of classical herpetic infection causing vesicoulcerative stomatitis in a family group (eight animals) of Callithrix jacchus is described. In all eight infected animals, human herpesvirus 1 (HHV-1) was identified as the causative agent. This was confirmed by histologic, immunohistologic, and molecular biologic investigations, as well as by virus isolation. The clinical picture, the macroscopic appearance, and the histologic results indicated a herpes infection as the cause of mortality. Alterations of the oral mucous membranes were erosive to ulcerative with typical intranuclear inclusions. Immunohistologic and molecular biologic techniques clearly identified the HHV-1 virus and excluded other possible primate herpesviruses such as Bvirus, SA8, HVP-2, and Herpes tamarinus. The significance of this herpesvirus infection for colony management is discussed.

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Section: Pathologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

Fatal Herpes simplex Infection in a Group of Common Marmosets (Callithrix jacchus)

Mätz‐Rensing¹,

Jentsch

Rensing³

et al. 2003

Vet Pathol

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“…Lesions vary from local to generalized vesicles and ulcers, conjunctivitis, encephalitis and death. Owl monkeys, lemurs, marmosets, gibbons, gorillas and tamarins have been reported with generalized disease (high morbidity and mortality), whereas chimpanzees usually have localized disease confined to the genitals, labia, skin and oral cavity 56,57 …”

Section: Introductionmentioning

confidence: 99%

Nonhuman primate dermatology: a literature review

Bernstein¹,

Didier

2009

Veterinary Dermatology

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In general, veterinary dermatologists do not have extensive clinical experience of nonhuman primate (NHP) dermatoses. The bulk of the published literature does not provide an organized evidence-based approach to the NHP dermatologic case. The veterinary dermatologist is left to extract information from both human and veterinary dermatology, an approach that can be problematic as it forces the clinician to make diagnostic and therapeutic decisions based on two very disparate bodies of literature. A more cohesive approach to NHP dermatology – without relying on assumptions that NHP pathology most commonly behaves similarly to other veterinary and human disease – is required. This review of the dermatology of NHP species includes discussions of primary dermatoses, as well as diseases where dermatologic signs represent a significant secondary component, provides a first step towards encouraging the veterinary community to study and report the dermatologic diseases of nonhuman primates.

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“…The use of potentially pathogenic, replication-competent viruses in humans for tumor therapy is dependent upon the demonstration that the mutant viruses will not cause additional disease. The New World owl monkey, Aotus nancymae (karyotype 1, formerly believed to be Aotus trivirgatus [18]), was selected as a nonhuman primate model to test the safety of G207 because of its exquisite sensitivity to HSV (20,24,38). Peripheral inoculation of 100 PFU of wild-type HSV-1 or -2 is lethal (37).…”

mentioning

confidence: 99%

Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation of Intracerebral Injection in Nonhuman Primates

Hunter¹,

Martuza²,

Feigenbaum³

et al. 1999

J Virol

173

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This study examined the safety of intracerebral inoculation of G207, an attenuated, replication-competent herpes simplex virus type 1 (HSV-1) recombinant, in nonhuman primates. Sixteen New World owl monkeys (Aotus nancymae [karyotype 1, formerly believed to be A. trivirgatus]), known for their exquisite susceptibility to HSV-1 infection, were evaluated. Thirteen underwent intracerebral inoculation with G207 at doses of 107 or 109 PFU, two were vehicle inoculated, and one served as an infected wild-type control and received 103 PFU of HSV-1 strain F. HSV-1 strain F caused rapid mortality and symptoms consistent with HSV encephalitis, including fever, hemiparesis, meningitis, and hemorrhage in the basal ganglia. One year after G207 inoculation, seven of the animals were alive and exhibited no evidence of clinical complications. Three deaths resulted from nonneurologic causes unrelated to HSV infection, and three animals were sacrificed for histopathologic examination. Two animals were reinoculated with G207 (107 PFU) at the same stereotactic coordinates 1 year after the initial G207 inoculation. These animals were alive and healthy 2 years after the second inoculation. Cerebral magnetic resonance imaging studies performed both before and after G207 inoculation failed to reveal radiographic evidence of HSV-related sequelae. Despite the lack of outwardly observable HSV pathology, measurable increases in serum anti-HSV titers were detected. Histopathological examination of multiple organ tissues found no evidence of HSV-induced histopathology or dissemination. We conclude that intracerebral inoculation of up to 109 PFU of G207, well above the efficacious dose in mouse tumor studies, is safe and therefore appropriate for human clinical trials.

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Herpesvirus simplex Infection

Cited by 7 publications

References 10 publications

Fatal Herpes simplex Infection in a Group of Common Marmosets (Callithrix jacchus)

Fatal Herpes simplex Infection in a Group of Common Marmosets (Callithrix jacchus)

Nonhuman primate dermatology: a literature review

Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation of Intracerebral Injection in Nonhuman Primates

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