Herpesvirus-Associated Neurological Disease in a Donkey

Vengušt, Modest; Wen, Xin; Bienzle, Dorothee

doi:10.1177/104063870802000620

Cited by 22 publications

(19 citation statements)

References 11 publications

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“…2002). A gamma herpesvirus similar to these has been identified in a donkey with neurological disease (Vengust et al . 2008).…”

Section: Equine/asinine Herpesvirusmentioning

confidence: 91%

Respiratory disease in the donkey

Thiemann

2011

Equine Veterinary Education

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Summary The donkey suffers from a similar range of respiratory diseases as the horse; however, there are a number of subtle variations, knowledge of which can influence the success of treatment. As an animal adapted to a semi‐arid terrain, there are variations in physiology, anatomy and disease susceptibility. The nonathletic nature of the donkey means that delayed presentation is common with many diseases and, while there may be enhanced resistance to some transboundary and parasitic diseases, there may be equal or increased severity of illness to some endemic diseases, e.g. equine influenza. Donkeys frequently live to geriatric ages and the clinician should be aware of the increased risk of conditions such as tracheal collapse, fibrosing pneumonia and neoplasia in this age group. As with any condition that causes stress and inappetance, respiratory disease in the donkey may be complicated by hyperlipaemia and good nursing care is an essential component of treatment.

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“…2002). A gamma herpesvirus similar to these has been identified in a donkey with neurological disease (Vengust et al . 2008).…”

Section: Equine/asinine Herpesvirusmentioning

confidence: 91%

Respiratory disease in the donkey

Thiemann

2011

Equine Veterinary Education

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“…The 195 nt sequence obtained showed 98-100% nucleotide identity when compared with AHV-5 sequences available in GenBank using the blastn tool (http://www.ncbi.nlm.nih.gov/blast/Blast.cgi), and between 85–97% nucleotide identity with other available equine herpesviruses originating from domestic or wild equids. In order to gain more sequence information a primer pair designed for gammaherpesvirus also targeting the DNA polymerase gene and including the fragment produced by the consensus PCR was applied to the extracted DNA [21]. The PCR products were sequenced in both directions with the same primers.…”

Section: Introductionmentioning

confidence: 99%

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

et al. 2012

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A standardbred gelding with a history of 10 days pyrexia and lethargy was referred to the Equine Hospital at the Swedish University of Agricultural Sciences in Uppsala, Sweden.The horse had tachypnea with increased respiratory effort and was in thin body condition. Laboratory findings included leukocytosis, hyperfibrinogenemia and hypoxemia. Thoracic radiographs showed signs of pneumonia with a multifocal nodular pattern, which in combination with lung biopsy findings indicated Equine Multinodular Pulmonary Fibrosis (EMPF). EMPF is a recently described disease in adult horses with clinical signs of fever, weight loss and respiratory problems. The pathological findings include loss of functional pulmonary parenchyma due to extensive nodular interstitial fibrosis which has been related to infection with the equine herpesvirus type 5 (EHV-5). In this case, lung biopsy and tracheal wash samples tested positive for both asinine herpesvirus type 5 (AHV-5) and EHV-5 using PCR assays. The horse failed to respond to treatment and was euthanized for humane reasons. Postmortem examination confirmed the diagnosis of EMPF. This case suggests that not only EHV-5 alone should be considered in association with the development of this disease.

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“…However, EHV-2 has been isolated from juvenile and adult horses with upper respiratory tract disease and conjunctivitis; the virus has also been associated with development of pneumonia. 2,8,10 Gammaherpesvirus infections have also been reported in donkeys and mules: A virus similar to asinine herpesvirus 5 was isolated from a pharyngeal swab of a donkey with neurologic disease, 15 and asinine herpesviruses 4 and 5 were identified in donkeys with interstitial pneumonia. 11 Another gammaherpesvirus, Equid herpesvirus 7 (EHV-7; order Herpesvirales, family Herpesviridae , subfamily Gammaherpesvirinae , genus Unassigned), also known as asinine herpesvirus 2 (AHV-2), has been isolated from the blood of a healthy donkey and from the nasal secretions of a mule following an outbreak of respiratory disease.…”

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confidence: 99%

Abortion in a Mediterranean miniature donkey (Equus asinus) associated with a gammaherpesvirus similar to Equid herpesvirus 7

et al. 2015

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Fetal tissues and placenta from a third trimester Mediterranean miniature donkey (Equus asinus) abortion were submitted to the Washington State University, Washington Animal Disease Diagnostic Laboratory for abortion diagnosis. Microscopic examination of formalin-fixed tissues revealed multifocal necrotizing placentitis. Several cells within the necrotic foci contained large, eosinophilic, intranuclear inclusions. Virus isolation from fresh, frozen placenta identified a cytopathic, syncytia-forming virus. Polymerase chain reaction (PCR) from the cultured virus using degenerate universal herpesvirus primers amplified a 699—base pair portion of the DNA polymerase gene. The PCR amplicon had 96.7% nucleotide identity with the DNA polymerase gene of Equid herpesvirus 7 (EHV-7; asinine herpesvirus 2), a gammaherpesvirus. An identical sequence was obtained when the same degenerate herpesvirus primers were used for PCR on the formalin-fixed placenta. Additionally, the amplicon had complete identity with short sequences of asinine herpesviruses that have been published in association with interstitial pneumonia in donkeys. EHV-7 has previously been isolated from nasal secretions of normal donkeys and mules. Our report describes a case of abortion associated with EHV-7 or a similar virus.

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Herpesvirus-Associated Neurological Disease in a Donkey

Cited by 22 publications

References 11 publications

Respiratory disease in the donkey

Respiratory disease in the donkey

Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report

Abortion in a Mediterranean miniature donkey (Equus asinus) associated with a gammaherpesvirus similar to Equid herpesvirus 7

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