Herpes Zoster Incidence in Inflammatory Bowel Disease Patients: A Population-Based Study

Côté-Daigneault, Justin; Bessissow, Talat; Nicolae, M; Nie, Rui; Bitton, Alain; Lakatos, László; Brassard, Paul

doi:10.1093/ibd/izy311

Cited by 27 publications

(31 citation statements)

References 28 publications

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“…Recently, one cohort study conducted by Soh et al 1. published in Gut and Liver disclosed that inflammatory bowel disease (IBD)was associated with an elevated risk of herpes zoster (adjusted hazard ratio of 1.40 in ulcerative colitis and 2.13 in Crohn’s disease), which was consistent with the findings of previous studies 2,3. Some of my ideas are shared with the readers.…”

supporting

confidence: 72%

Inflammatory Bowel Disease and the Risk of Herpes Zoster

Lai

2019

Gut and Liver

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supporting

confidence: 72%

Inflammatory Bowel Disease and the Risk of Herpes Zoster

Lai

2019

Gut and Liver

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“…The activation and infection of VZV in sensory neurons will cause severe inflammation and immune response, which is the body's defense response to pathogenic microorganisms (Almanzar et al, 2019;Cote-Daigneault et al, 2019). Similarly, our GO enrichment results showed that a large number of VZV-induced DEGs in neuroblastoma cells were mainly related to "inflammatory response, " "immune response, " "response to lipopolysaccharide, " and "chemotaxis" (Figure 3).…”

Section: Discussionmentioning

confidence: 60%

Transcriptome Analysis Reveals the Role of Cellular Calcium Disorder in Varicella Zoster Virus-Induced Post-Herpetic Neuralgia

Yang

et al. 2021

Front. Mol. Neurosci.

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As a typical neuropathic pain, post-herpetic neuralgia (PHN) is a common complication of herpes zoster (HZ), which seriously affects the normal life and work of patients. The unclear pathogenesis and lack of effective drugs make the clinical efficacy of PHN unsatisfactory. Here, we obtained the transcriptome profile of neuroblastoma cells (SH-SY5Y) and DRG in rats infected with varicella zoster virus (VZV) by transcriptome sequencing (RNA-Seq) combined with publicly available gene array data sets. Next, the data processing of the transcriptome map was analyzed using bioinformatics methods, including the screening of differentially expressed genes (DEGs), Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Finally, real-time fluorescent quantitative PCR (qRT-PCR) was used to detect the expression of calcium-related genes, and calcium fluorescent probes and calcium colorimetry were used to evaluate the distribution and content of calcium ions in cells after VZV infection. Transcriptome data analysis (GO and KEGG enrichment analysis) showed that calcium disorder played an important role in SH-SY5Y cells infected by VZV and dorsal root ganglion (DRG) of the PHN rat model. The results of qRT-PCR showed that the expression levels of calcium-related genes BHLHA15, CACNA1F, CACNG1, CHRNA9, and STC2 were significantly upregulated, while the expression levels of CHRNA10, HRC, and TNNT3 were significantly downregulated in SH-SY5Y cells infected with VZV. Our calcium fluorescent probe and calcium colorimetric test results showed that VZV could change the distribution of calcium ions in infected cells and significantly increase the intracellular calcium content. In conclusion, our results revealed that the persistence of calcium disorder caused by VZV in nerve cells might be a crucial cause of herpetic neuralgia, and a potential target for clinical diagnosis and treatment of PHN.

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“…Live/Inactivated Vaccine Herpes Zoster IBD patients are at increased risk of developing HZ, as has been shown in several large studies [59][60][61][62]. In 2013, Long et al [59] compared the HZ risk among 108,000 IBD patients compared with 434,000 non-IBD individuals.…”

Section: Human Papillomavirusmentioning

confidence: 99%