Herpes zoster, immunological deterioration and disease progression in HIV-1 infection

Veenstra, J.; Krol, Anneke; Praag, Rieneke M. E. van; Frissen, P. H. J.; Schellekens, P. T. A.; Lange, Joep M. A.; Coutinho, R. A.; Meer, J.T.M. van der

doi:10.1097/00002030-199510000-00006

Cited by 101 publications

(77 citation statements)

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“…In our study, HZ cases had lower CD4 ϩ percentages than non-HZ controls, which is in agreement with previous reports (40). However, using traditional Teff markers, we did not find significant associations between protection against HZ and the proportions of CD4 ϩ Teff.…”

supporting

confidence: 92%

Immune Correlates of Herpes Zoster in HIV-Infected Children and Youth

Weinberg

Huang

Song

et al. 2012

J Virol

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To identify immunologic factors that modulate the risk of herpes zoster (HZ), we compared varicella-zoster virus (VZV)-specific and nonspecific T-cell subpopulations of 47 HIV-infected children before they developed HZ with those of 141 VZV-positive HZ-negative matched controls. Compared with controls, HZ cases had lower VZV-specific CD8 ؉ CD107a ؉ cell percentages independently of CD4 ؉ percentages or HIV loads, suggesting that VZV-specific cytotoxic T cells are protective against HZ. In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ.

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supporting

confidence: 92%

Immune Correlates of Herpes Zoster in HIV-Infected Children and Youth

Weinberg

Huang

Song

et al. 2012

J Virol

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“…VZV was not an independent predictor of HIV disease progression. 12 Interestingly, in our study, the incidence of complications was smaller in the group with lower CD4 count, suggesting that most clinically evident complications were proportional to the activity of the immune response more than to specific viral cytopathic destruction. Exceptions were ocular hypertension and dry eye.…”

Section: Discussionmentioning

confidence: 41%

“…The incidence of varicella zoster viral (VZV) infection increases with declining CD4 þ lymphocyte count in HIV-infected patients: in the Amsterdam Cohort Study, 12 the incidence of VZV was 31.2 per 1000 person years at CD4 þ count 4500 cells/ml and 97.5 per 1000 person years at CD4 þ count o200 cells/ml. VZV was not an independent predictor of HIV disease progression.…”

Section: Discussionmentioning

confidence: 99%

Course and complications of varicella zoster ophthalmicus in a high HIV seroprevalence population (Cape Town, South Africa)

Richards

Maartens

Davidse

2007

Eye

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“…The incidence of HZO in HIV cases has not changed significantly since the advent of highly active antiretroviral therapy (HAART). 7 The most common vision-affecting complications of HZO are corneal opacities due to scarring, neovascularisation, neurotrophic or secondarily infected ulcers, the sequelae of uveitis (i.e. cataract and glaucoma), necrotising retinitis, posterior vascular occlusions and optic neuritis.…”

mentioning

confidence: 99%

“…Some studies demonstrated no increased incidence of HZO with duration of HIV and presumably declining CD4 count. 7,[13][14][15][16] It has been suggested that HZO occurs in patients with moderate degrees of immunodeficiency, and much less so in patients with profound immunodeficiency, 7,13,16,17 suggest that, in contrast to opportunistic infections such as cytomegalovirus that occur in profound immunodeficiency, HZO rather occurs in immunodysregulation. 18 We aimed to evaluate the sensitivity of Hutchinson's sign as a marker of ocular involvement in a series of consecutive HZO cases in a population at risk for HIV disease, and to explore the relationship between CD4 counts in the HIV-positive subgroup with and without a positive Hutchinson's sign.…”

mentioning

confidence: 99%