Herpes zoster: Family history and psychological stress—Case–control study

Lasserre, A.; Blaizeau, Fanette; Gorwood, P.; Bloch, K.; Chauvin, Pierre; Liard, François; Blanchon, Thierry; Hanslik, Thomas

doi:10.1016/j.jcv.2012.06.020

Cited by 62 publications

(54 citation statements)

References 35 publications

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“…Of note, they were not specifically designed to address this question or were conducted in populations with specific co-comorbidities [6, 19]. In a prospective matched case–control study Lasserre et al [18] found that diabetes was associated with HZ in the univariate analysis, but the association was not significant in the multivariate analysis. Not taking into account an interaction between age and type II diabetes may result in underestimating the effect of type II diabetes in the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…However, the impact of chronic diseases is still unclear. Multiple chronic conditions have been identified as potential risk factors for HZ, including lung disease and COPD [6, 19, 20], liver disease [6], renal failure [6], depression [16, 18, 24], coronary diseases, hyperlipidemia, osteoarthritis, hypothyroism [16]. For many of those, the population-attributable fraction, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…An association between diabetes and HZ is supported by observations of Okamoto et al [14] who showed that subjects with diabetes between 41 and 79 years had significantly lower cell mediated immunity to varicella zoster virus than did healthy individuals. Epidemiological studies investigating the association between HZ and diabetes are few and have yielded contradictory results, with studies suggesting that diabetes is a risk factor for HZ [15–17] and others failing to demonstrate a statistically significant association [5, 6, 18]. Most of these studies addressed multiple risk factors for HZ, among which figured diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Risk of herpes zoster among diabetics: a matched cohort study in a US insurance claim database before introduction of vaccination, 1997–2006

et al. 2014

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PurposeTo assess whether diabetes is a risk factor for herpes zoster (HZ).MethodsWe conducted a retrospective cohort study using the Integrated Health Care Information Services database, during the period 1997–2006. A type I diabetes cohort, a type II diabetes cohort and two non-diabetic cohorts matched for date of enrolment and duration of follow-up were defined. HZ and diabetes were defined using a combination of ICD-9 and prescription drug codes. Individuals with immunosuppressive conditions or treatments were excluded. Cox Proportional Hazards regression analysis using a stepwise method with backward elimination was applied to estimate the hazard ratios (HR) of HZ, including age, gender and co-morbidities as covariates.ResultsThe study population comprised 380,401 and 20,397 type II and type I diabetic subjects respectively, as well as 1,521,604 and 81,588 matched controls. The median ages were 55, 35, 33 and 29 years, respectively. HZ incidence was 4.59, 2.13, 1.97, and 1.82 per 1,000 person-years, respectively. There was no evidence of an impact of type I diabetes on the risk of HZ. Type II diabetes was associated with an increased risk for HZ in subjects ≥65 (HR 3.12; 95 % CI 2.77–3.52, adjusted for gender) and in subjects between 40 and 64 (HR 1.51; 95 % CI 1.42–1.61) years of age. Cardiac disease and chronic pulmonary disease were also risk factors (HR 1.92; 95 % CI 1.73–2.13 and HR 1.52; 95 % CI 1.38–1.67) in non-diabetic subjects.ConclusionsThis study suggests that type II diabetes is associated with an increased risk of developing HZ, which was particularly high in adults 65 years and older and moderately increased in adults under 65 years of age.Electronic supplementary materialThe online version of this article (doi:10.1007/s15010-014-0645-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk of herpes zoster among diabetics: a matched cohort study in a US insurance claim database before introduction of vaccination, 1997–2006

et al. 2014

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“…In humans there is some evidence that stress can influence susceptibility to infectious skin diseases. There are several reports suggesting that recurrences of cutaneous herpes simplex are associated with psychosocial stress and depression (Pereira et al, 2003; Goldmeier et al, 2008; Chida and Mao, 2009) and that the occurrence of herpes zoster is preceded by more severe life stressors (Schmader et al, 1990; Mehta et al, 2004; Lasserre et al, 2012). …”

Section: Clinical Relevancementioning

confidence: 99%

Nerve-derived transmitters including peptides influence cutaneous immunology

Madva

Granstein

2013

Brain, Behavior, and Immunity

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Clinical observations suggest that the nervous and immune systems are closely related. For example, inflammatory skin disorders; such as psoriasis, atopic dermatitis, rosacea and acne; are widely believed to be exacerbated by stress. A growing body of research now suggests that neuropeptides and neurotransmitters serve as a link between these two systems. Neuropeptides and neurotransmitters are released by nerves innervating the skin to influence important actors of the immune system, such as Langerhans cells and mast cells, which are located within close anatomic proximity. Catecholamines and other sympathetic transmitters that are released in response to activation of the sympathetic nervous system are also able to reach the skin and affect immune cells. Neuropeptides appear to direct the outcome of Langerhans cell antigen presentation with regard to the subtypes of Th cells generated and neuropeptides induce the degranulation of mast cells, among other effects. Additionally, endothelial cells, which release many inflammatory mediators and express cell surface molecules that allow leukocytes to exit the bloodstream, appear to be regulated by certain neuropeptides and transmitters. This review focuses on the evidence that products of nerves have important regulatory activities on antigen presentation, mast cell function and endothelial cell biology. These activities are highly likely to have clinical and therapeutic relevance.

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“…Factors such as being away from one's family, disruption of the circadian cycle, working in a confined space, isolation from the outside world, and potential dangers of the missions could increase the stress level in submarine crews (29). Stress could lead to development or aggravation of some oral lesions, including lichen planus (7,9), aphthous stomatitis (30,31), and herpes lesions (30,32). Recurrent aphthous stomatitis is a common and painful mucosal lesion; its possible etiologic factors include genetic factors, vitamin deficiency, immune dysfunction, stress, etc.…”

Section: Discussionmentioning

confidence: 99%