Herpes Zoster and Malignancy

Wright, Edwin T.; Winer, Louis H.

doi:10.1001/archderm.1961.01580140068007

Cited by 62 publications

(10 citation statements)

References 3 publications

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“…In present series the incidence of leukemia was 1.7% -a number that is considerably higher than the incidence of leukemia in a standard population. This fact is well documented in several reports from the literature (Ferreira Marques, 1938;Hallgren, 1950;Wright and Winer, 1961).…”

Section: H Ellgrcn and Hcrsle A Statistical And Clinical Studysupporting

confidence: 66%

A Statistical and Clinical Study of Herpes Zoster

Hellgren¹,

Hersle²

1966

Geront clin

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Section: H Ellgrcn and Hcrsle A Statistical And Clinical Studysupporting

confidence: 66%

A Statistical and Clinical Study of Herpes Zoster

Hellgren¹,

Hersle²

1966

Geront clin

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“…The literature on the risk of HZ among patients with solid tumor malignancies is quite limited, especially for patients diagnosed in recent years (25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The reported percentage developing HZ has ranged from approximately 1.5% to 12%.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology of Herpes Zoster in Patients with Newly Diagnosed Cancer

Habel

Ray

Silverberg

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Given the limited literature, we conducted a study to examine the epidemiology of herpes zoster (HZ) among newly diagnosed cancer patients.Methods: We identified adult health plan members of Kaiser Permanente Northern California diagnosed with invasive cancer from 2001 to 2005. Electronic health records with inpatient and outpatient diagnoses, laboratory tests, and antiviral medications were used to identify HZ diagnoses from 2001 to 2006. HZ diagnoses and associated complications were confirmed by medical chart review. Treatment with chemotherapy and corticosteroids was used to classify patients by immunosuppression level.Results: Among 14,670 cancer patients, 424 were diagnosed with HZ during follow-up (median 22 months). The incidence of HZ was 31/1,000 person-year (PY) in patients with hematologic malignancies and 12/1,000 PY in patients with solid tumors. The corresponding 2-year cumulative incidence of HZ was approximately 6% and 2%, respectively. Compared with incidence rates of HZ reported in a general US population, the age-and sex-standardized rates of HZ were 4.8 times higher [95% confidence interval (CI), 4.0-5.6] in patients with hematologic malignancies and 1.9 times higher (95% CI, 1.7-2.1) in those with solid tumors. HZ risk increased with increasing level of immunosuppression. Among HZ cases, 19% with hematologic malignancies and 14% with solid tumors had HZ-associated pain for at least 30 days. The corresponding numbers for nonpain-related complications were 30% and 18%, respectively.Conclusions: Cancer patients are at substantially increased risk of HZ and among those with HZ, complications are relatively common.Impact: Better HZ prevention and treatment options for cancer patients are needed. Cancer Epidemiol Biomarkers Prev; 22(1); 82-90. Ó2012 AACR.

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“…Associated diseases included 4 with diabetes, 3 postgastrectomy patients (benign gastric ulcers), 1 patient with discoid lupus erythematosus, 1 with sarcoid, and 3 with ulcerative colitis. None of these were on steroids or had been Susan Lightman, R. J. Marsh, and David Powell for at least 4 months.…”

Section: Resultsmentioning

confidence: 99%

Herpes zoster ophthalmicus: a medical review.

Lightman¹,

Marsh²,

Powell³

1981

British Journal of Ophthalmology

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We therefore decided to carry out a retrospective study on our patients to see if this impression was correct and to see if the infection and ocular complications were more severe in those patients with underlying disease. Patients and methodsOur study was based on patients attending the Zoster Clinic at Moorfields Eye Hospital over the past 9 years. The vast majority of the patients were referred directly to the Casualty Department from their general practitioner within the first 10 days of onset of the rash. The diagnosis was confirmed in the Casualty Department and preliminary treatment started. Within the next few days the patients were seen in the Zoster Clinic, which is part of the External Diseases Group of Clinics under the auspices of the Professorial Unit at Moorfields. Apart from the ocular examination all patients had a medical history taken and underwent the following tests: a full blood count, differential white blood count and film, erythrocyte sedimentation rate (ESR), liver function tests, electrophoretic strip, blood sugar, and chest x-ray. The patients were also Correspondence to Dr S. Lightman. asked about previous zoster infections and whether they were on systemic steroids. Regular follow-up appointments were then made until the eye was quiet or they defaulted.Those patients whose blood tests were abnormal (abnormal being taken as anything outside the normal range in biochemistry, and differing from a normal differential white blood count) were looked at in detail and multivariate analysis was undertaken with age, sex, haematological results, biochemical results, and type of eye problem as variants. Probabilities were then computed by means of the Fisher exact probability test. ResultsOne thousand patients have attended the Zoster Clinic in the last 9 years. A small proportion of the patients had no ocular involvement-the infection being confined to the skin. Thirty-six patients reported previous zoster infections. These had usually been thoracic or lumbar, but 1 patient had suffered ophthalmic zoster on the other side 18 years previously and had visible pitting and depigmentation in the skin on that side.

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Herpes Zoster and Malignancy

Cited by 62 publications

References 3 publications

A Statistical and Clinical Study of Herpes Zoster

A Statistical and Clinical Study of Herpes Zoster

The Epidemiology of Herpes Zoster in Patients with Newly Diagnosed Cancer

Herpes zoster ophthalmicus: a medical review.

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