Herpes zoster and its complications in Italy: An observational survey

Paparatti, Umberto di Luzio; Arpinelli, Fabio; Visoná, Giovanni

doi:10.1016/s0163-4453(99)90079-8

Cited by 57 publications

(50 citation statements)

References 8 publications

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“…Although herpes zoster is not a reportable disease, an estimated 200,000-250,000 cases occur annually in Italy [di Luzio Paparatti et al, 1999]. The most notable manifestations of shingles in immunocompetent persons are acute neuralgia (pain occurring within 30 days of the onset of the rush) and persistent pain, traditionally termed post-herpetic neuralgia.…”

Section: Introductionmentioning

confidence: 99%

No evidence of family history as a risk factor for herpes zoster in patients with post‐herpetic neuralgia

Gatti

Pica

Boccia

et al. 2010

Journal of Medical Virology

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Little is known about reactivation of latent varicella zoster virus as herpes zoster in individuals with no underlying immunosuppression. Risk factors include age, sex, ethnicity, exogenous boosting of immunity from varicella contacts, underlying cell-mediated immune disorders, mechanical trauma, psychological stress, and immunotoxin exposure. An association between herpes zoster and family history of zoster has been proposed. A case-control study involving patients affected by post-herpetic neuralgia, which usually follows more severe acute herpes zoster, was performed. The patients with post-herpetic neuralgia were enrolled at the Pain Clinic of the Policlinico Tor Vergata in Rome, Italy, within 1 year from the onset of acute zoster. The controls matched for sex and age were chosen among healthy subjects without a history of herpes zoster presenting at the Internal Medicine Outpatient Clinic for hypertension in the same time period. All the participants in the study gave informed consent and were interviewed by medically trained and blinded investigators using a questionnaire. Similar proportions of the patients and the controls reported a family history of herpes zoster irrespective of the degree of relationship, i.e., 17.4% and 18.2%, respectively, by analyzing only the first-degree relatives [RR 1.03 (CI 95%: 0.78-1.37)], and 28.4% and 29.6%, respectively, by analyzing the total number of relatives [RR 1.03 (CI 95%: 0.81-1.31)]. Further and larger prospective cohort studies are needed to ascertain whether a family history of herpes zoster is really an independent predictor of zoster in different geographical settings.

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Section: Introductionmentioning

confidence: 99%

No evidence of family history as a risk factor for herpes zoster in patients with post‐herpetic neuralgia

Gatti

Pica

Boccia

et al. 2010

Journal of Medical Virology

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“…La mayoría de los estudios están realizados en población hospitalaria y en Estados Unidos y Gran B r e t a ñ a 2 . Los datos de incidencia en la literatura oscilan entre 1,3 y 4,8 casos /1.000 población por a ñ o 2 . Existen diferencias en los distintos países, por ejemplo la incidencia es menor en Estados Unidos que en Gran Bretaña 2 ; y también dependiendo del ámbito donde se realice el estudio, aportando cifras más bajas en los realizados en el primer nivel.…”

Section: El Herpes Zoster Es El Resultado De La Re a C T I V Ación Deunclassified

“…Los datos de incidencia en Atención Primaria oscilan entre 2,0/1.000/año 3 en Islandia y 4,1/1.000/año 2 en Italia en pacientes mayores de 15 años. En estos trabajos se presupone que todos los pacientes afectados de herpes zoster solicitan atención médica en el nivel primario, bien como primer paso por su accesibilidad y por la buena relación entre los médicos de primaria y los pacientes, o bien en un segundo paso después de acudir a urgencias o ser valorado por médicos de atención especializada 2 .…”

Section: El Herpes Zoster Es El Resultado De La Re a C T I V Ación Deunclassified

“…En general en estudios realizados en Atención Primaria se observa que en los pacientes con edades inferiores a 60 años, el curso clínico del herpes zoster es benigno y sin complicaciones 3 . En un estudio realizado por Paparatti et al 2 la tasa de complicaciones fue de 26,1%. Las distintas complicaciones se reflejan en la tabla II 1 , 5 , 8 .…”

Section: Complicacionesunclassified

“…Las distintas complicaciones se reflejan en la tabla II 1 , 5 , 8 . Las complicaciones son más frecuentes al aumentar el número de dermatomas afectados 2 y a mayor edad 2 y no hay diferencia significativa en cuanto al sexo 2 . La principal complicación del herpes zoster es la neuralgia post-herpética 1 , 8 .…”

Section: Complicacionesunclassified

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Manejo del episodio agudo de herpes zoster y la neuralgia post-herpética

Pozo¹,

Gómez²,

González

2002

Medifam

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RESUMEN El herpes zoster es el resultado de la re a c t i v ación del virus de la varicela zoster, siendo más frecuente en pacientes con edad avanzada y con la in ABSTRACT Herpes zoster results from reactivation of the varicella-zoster virus. It is more commom in elderly and inmunocompromised patients. The clinical course of herpes zoster, in patients of Primary Health Care and younger than 60 years of age, is beningn and without complications. The main complication of herpes zoster is the postherpetic neuralgia, which is pain that appears in the affected INTRODUCCIÓNEl herpes zoster es el cuadro clínico constituido por las manifestaciones dermatológicas (erupción vesiculosa) y neurológica (dolor) que se produce por la reactivación del virus varicela zoster. El dolor es el síntoma más común por el que los pacientes con herpes zoster solicitan atención médica 1 .

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Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease‐Modifying Antirheumatic Drugs

Pappas

Hooper

Kremer

et al. 2015

Arthritis Care & Research

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Objective. To identify the rheumatoid arthritis (RA) characteristics associated with increased herpes zoster (HZ) risk in the Corrona registry RA patients, and to evaluate the risk in initiators of tumor necrosis factor inhibitors (TNFi) or non-TNFi biologic agents or (among those who were currently on or had been previously treated with methotrexate [MTX]) conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) other than MTX. Methods. Cox regression modeling estimated the association between first HZ incidence and selected RA characteristics, including disease activity. Medication-related risk for HZ in RA patients taking current or past MTX (to exclude milder RA disease) were categorized by treatment initiation (TNFi versus non-TNFi versus csDMARD). Hazard ratios (HRs) estimated HZ risk of each treatment initiation category after stratification on trimmed propensity score (PS) quintiles to control for potential confounders. Results. A total of 28,852 patients contributed 95,287 person-years. Seven hundred twenty-nine observed HZ cases yielded a 7.7 (95% confidence interval [95% CI] 7.1-8.2) per 1,000 patient-years crude incidence rate, lower than found in prior RA cohorts. However, consistent with prior studies, increasing age (HR 1.14, 95% CI 1.09-1.19 per 5 years) and prednisone therapy ‡7.5 mg/day (HR 1.81, 95% CI 1.23-2.67) were associated with a higher HZ risk. Referent to TNFi exposure, PS-stratified analysis showed an HR for csDMARDs of 1.36 (95% CI 0.82-2.25) and for non-TNFi of 0.83 (95% CI 0.51-1.38). Conclusion. In the Corrona registry, the HZ risk in RA patients taking prior or current MTX increased with older age and higher prednisone dose. The HZ risk among these patients with RA was comparable after initiation of TNFi versus non-TNFi versus csDMARDs.

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Herpes zoster and its complications in Italy: An observational survey

Cited by 57 publications

References 8 publications

No evidence of family history as a risk factor for herpes zoster in patients with post‐herpetic neuralgia

No evidence of family history as a risk factor for herpes zoster in patients with post‐herpetic neuralgia

Manejo del episodio agudo de herpes zoster y la neuralgia post-herpética

Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease‐Modifying Antirheumatic Drugs

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