Herpes-Type Virus Particles in Tissue Culture of Kaposi's Sarcoma From Different Geographic Regions2

Giraldo, Gaetano; Beth, E.; Haguenau, F

doi:10.1093/jnci/49.6.1509

Cited by 194 publications

(38 citation statements)

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“…Before the discovery of HHV-8 (56), herpesvirus particles were described in a short-term tissue culture of a KS lesion (92,115), and they were subsequently identified as cytomegalovirus (116). HHV-8 exhibits typical herpesvirus morphology: 100-to 150-nm particles with a lipid envelope and an electron-dense central core (242).…”

Section: Structure and Morphologymentioning

confidence: 99%

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

Ablashi¹,

Chatlynne²,

Whitman³

et al. 2002

Clin Microbiol Rev

275

182

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Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), discovered in 1994, is a human rhadinovirus (gamma-2 herpesvirus). Unlike other human herpesviruses (herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, cytomegalovirus, HHV-6, and HHV-7), it is not widespread in the general population and has many unique proteins. HHV-8 is strongly associated with all subtypes of Kaposi's sarcoma (KS), multicentric Castleman's disease, and a rare form of B-cell lymphoma, primary effusion lymphoma. In addition, HHV-8 DNA sequences have been found in association with other diseases, but the role of the virus in these diseases is largely unconfirmed and remains controversial. The seroprevalence of HHV-8, based on detection of latent and lytic proteins, is 2 to 5% in healthy donors except in certain geographic areas where the virus is endemic, 80 to 95% in classic KS patients, and 40 to 50% in HIV-1 patients without KS. This virus can be transmitted both sexually and through body fluids (e.g., saliva and blood). HHV-8 is a transforming virus, as evidenced by its presence in human malignancies, by the in vitro transforming properties of several of its viral genes, and by its ability to transform some primary cells in culture. It is not, however, sufficient for transformation, and other cofactors such as immunosuppressive cytokines are involved in the development of HHV-8-associated malignancies. In this article, we review the biology, molecular virology, epidemiology, transmission, detection methods, pathogenesis, and antiviral therapy of this newly discovered human herpesvirus

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Section: Structure and Morphologymentioning

confidence: 99%

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

Ablashi¹,

Chatlynne²,

Whitman³

et al. 2002

Clin Microbiol Rev

275

182

View full text Add to dashboard Cite

show abstract

“…This was primarily based on seroepidemiology; elevated antibody titres were measured in the sera of European and American patients with Kaposi's sarcoma in its classical form (Giraldo et al, 1972a(Giraldo et al, , 1978, and furthermore, virus particles, virion proteins and viral DNA were found in tumour biopsies Giraldo et al, 1972bGiraldo et al, , 1975Giraldo et al, , 1980Drew et al, 1982). Kaposi's sarcoma is associated with depressed functions of the cellular immune system; elevated antibody titres can be the consequence of endogenous virus reactivation, but serology is not applicable for proving a causal relationship between virus infection and tumour initiation or development.…”

Section: Regulatory Elements In the Ie1 Upstream Regionmentioning

confidence: 99%

Human Cytomegalovirus: Recent Aspects from Molecular Biology

Mach

Stamminger

Jahn

1989

Journal of General Virology

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“…Cytomegalovirus may be pathogenic in this setting but we consider it to be unproven at this time, with support only for criterion 4 following intracerebral inoculation of MCMV (Lussier, 1973(Lussier, , 1975Hudson, 1979). Kaposi's sarcoma Fifteen years ago, cultures of cells derived from Kaposi's sarcoma (KS) tissue were found to contain a herpesvirus which resembled CMV (Giraldo, Beth & Haguenau, 1972;. Serological studies later revealed that 100 % of patients with KS have IgG antibodies against CMV.…”

Section: Encephalitismentioning

confidence: 99%

The status of CMV as a human pathogen

Griffiths

Grundy

1988

Epidemiol. Infect.

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Cytomegalovirus (CMV) is a common infectious agent which is well adapted to its host. Following primary infection, which is almost always asymptomatic in people with normal immunity, the virus establishes latency at sites which are unknown. The virus is probably maintained in this latent state by immune surveillance mechanisms since immunosuppression frequently leads to reactivation of virus.Cytomegalovirus has been identified in most anatomical areas of the human body. The aim of this article is to define criteria for pathogenicity so that clinical and experimental data can be reviewed to determine if CMV is likely to cause disease at these various clinical sites. Thus, patients have been shown to die frequentlywithCMV but do they diefromit?

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Herpes-Type Virus Particles in Tissue Culture of Kaposi's Sarcoma From Different Geographic Regions2

Cited by 194 publications

References 0 publications

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

Human Cytomegalovirus: Recent Aspects from Molecular Biology

The status of CMV as a human pathogen

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