Herpes-simplex-Virusinfektionen

Abstract

The herpes simplex viruses type 1 and 2 (HSV 1 and 2) as typical members of the larger herpes virus group have the tendency to become latent after an inapparent primary infection. They are transmitted from person to person during episodes of reactivation. HSV 1 and 2 usually cause harmless mucosal infections. Usually HSV are kept in check by the immune system. An impaired immune response leads to HSV infections which can be life-threatening. Genital HSV infections are an important cause of genital ulcerations, and HSV 2 is a predisposing factor for HIV and AIDS. Worldwide the diagnostic possibilities for HSV are often inadequate. Despite the availability of modern chemotherapeutic agents, the treatment of HSV infections is in many cases less than satisfactory. Dermatologists play a major role in the early diagnosis and effective therapy of these infections. In this paper, the latest diagnostic and therapeutic, as well as prophylactic measures and vaccines, are reviewed.

Vegetating foot ulcer as presenting sign of acquired immunodeficiency syndrome

“…In the immunocompromised host, however, mucocutaneous lesions can be extensive or appear at unusual sites with atypical presentation [1,2] thus posing a diagnostic challenge, as shown in the following case.…”

Seronegative <i>Herpes simplex</i> Associated Esophagogastric Ulcer after Liver Transplantation

“…HSV infection is a well-known, chronic persistent viral infection of varying recurrence rate [1]. It has been reported that HSV can be the cause of esophagitis, as seen in immunodeficient patients under therapeutic immunosuppression [2, 3].…”

“…HSV manifestations after transplantation have been described; however, usually a time delay between organ transplantation and HSV infection – corresponding with the time necessary for the achievement of full therapeutic immunosuppression – is seen. The herpes virus group consists of the Herpes zoster virus and the Herpes simplex virus [1, 4], the former occurring much more often as a painful post-transplant infection [5, 6, 7]. Infections or recurrences of HSV after transplantation are much more uncommon and comprise case reports describing esophagitis and nephritis [8, 9].…”

Wichtige virale und bakterielle Infektionen der Haut und Schleimhäute

“…Bei älteren und immunsupprimierten Menschen können disseminierte Infektionen auftreten. Rekurrierende Infektionen lassen sich mit Triggerfaktoren wie Fieber, Sonnenlicht oder Stress sowie konsumierenden Erkrankungen und Tumoren in Zusammenhang bringen[10].…”