Herpes Simplex Virus Type-I and Pyogenic Granuloma: A Vascular Endothelial Growth Factor-Mediated Association

Hayderi, Lara El; Paurobally, D.; Fassotte, Marie-France; André, Josette; Arrese, Jorge E.; Sadzot-Delvaux, Catherine; Ruebben, Alexander; Nikkels, Arjen F.

doi:10.1159/000354570

Cited by 13 publications

(14 citation statements)

References 15 publications

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“…reported pyogenic granuloma like lesions caused by bacillary angiomatosis (BA). El Haydari et al . reported pyogenic granuloma like lesions after herpes virus infection.…”

Section: Discussionmentioning

confidence: 99%

“…Trauma, chronic irritation, some drugs, and pregnancy can trigger a pyogenic granuloma. [8][9][10] El Hayderi et al 12 reported a pyogenic granuloma after HSV-1 infection. Midilli et al 13 reported a nosocomial outbreak of disseminated orf infection in a burn unit.…”

Section: Discussionmentioning

confidence: 99%

“…Pyogenic granulomas after burn and infectious diseases angiomatosis (BA). El Haydari et al12 reported pyogenic granuloma like lesions after herpes virus infection. Similar to our case Midilli K et al…”

mentioning

confidence: 99%

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Poxvirus‐induced angiogenesis after a thermal burn

Özkaya

Taşkın

Taş

et al. 2014

The Journal of Dermatology

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Orf (contagious ecthyma) is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep, goats, and oxen. Parapoxviruses are transmitted to humans through contact with an infected animal or fomites. Orf virus infections can induce ulceration, and papulonodular, pustular, or ecthymic lesions of the skin after contact with an infected animal or contaminated fomite. Rarely, orf virus provokes extensive vasculo-endothelial proliferation as a skin manifestation. Here, we present the case of an 8-year old female with poxvirus-induced vascular angiogenesis that developed 10 days after a thermal burn. An 8-year-old female presented at our outpatient clinic with red swellings and a yellow-brown crust on them. After a thermal burn with hot water, she went to a clinic and the burn was dressed with nitrofurazone and covered for 2 days. When the dressing was removed after 2 days, nodules were seen in the burnt areas. When the clinical findings were considered with the histopathological features, a reactive vascular proliferation due to a viral agent was suspected. Following PCR, parapoxvirus ovis was detected. Viral infections such as pox virus can trigger pyogenic granulomas or pyogenic granuloma-like vascular angiogenesis. Infectious agents must be considered when dealing with pyogenic granuloma-like lesions.

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“…reported pyogenic granuloma like lesions caused by bacillary angiomatosis (BA). El Haydari et al . reported pyogenic granuloma like lesions after herpes virus infection.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Poxvirus‐induced angiogenesis after a thermal burn

Özkaya

Taşkın

Taş

et al. 2014

The Journal of Dermatology

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“…Da das Granuloma pyogenicum in der Regel wiederholt blutet und keine spontane Abheilungstendenz zeigt, ist eine operative Abtragung sinnvoll. Neben Traumen, hormonellen Faktoren und Medikamenten scheint insbesondere – ähnlich der durch Bartonella henselae induzierten bazillären Angiomatose – eine mikrobiologische Kolonisation mit Bakterien oder Viren , welche proangiogene Zytokine wie VEGF produzieren, an der reaktiven Gefäßproliferation von pathogenetischer Relevanz zu sein. Histologisch findet sich ein von einer lateralen epidermalen Collerette eingefasster, lobulär gegliederter, kapillärer Tumor (Abbildung a, b).…”

Section: Tumoren Des Säuglingsaltersunclassified

Pädiatrische Dermatohistopathologie – Histologie von Dermatosen im Neugeborenen‐ und Säuglingsalter

Wobser

Ernestus

Hamm

2015

J Deutsche Derma Gesell

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While neonatal skin physiology has been thoroughly examined using non-invasive techniques in recent years, only few systematic studies and review articles addressing the histopathology of neonatal skin have been published thus far. In most cases, histopathological findings of dermatoses in neonatal skin do not significantly differ from those seen in adult skin. Nevertheless, a comprehensive knowledge of embryonic and fetal skin development as well as the microanatomical structure of neonatal skin can contribute to a better understanding of various dermatoses of infancy. In the first part of this review article, we present the histopathological features of such skin diseases, which, though generally rare, almost exclusively appear during the first weeks of life due to distinctive structural and functional features of neonatal skin. The second part is dedicated to classic dermatoses of infancy and their histopathological features.

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“…It is believed that trauma and female sex hormones enhance expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) which will lead to evolution of the pyogenic granuloma [6,7,11,15]. Medications such as isotretinoin, acitretin, cyclosporine, lamivudine, docetaxel, imatinib, and indinavir may also be contributing factors [8,13,[15][16][17][18]. Infections such as caused by herpes simplex type-I and Epstein-Barr virus have also been incriminated [18].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Pyogenic Granuloma

Leung¹

2014

Clinics in Mother and Child Health

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Pyogenic granuloma, also known as lobular capillary hemangioma, is a common, acquired, benign vascular proliferation that typically develops as a small erythematous papule on the skin or oral mucosal surface. The papule usually enlarges quickly to a few millimeters over weeks and growth stabilizes over several months. Clinically, pyogenic granuloma presents as a soft dome-shaped papule/nodule or a sessile or pedunculated papule/nodule with a smooth, glistening, erosive, or friable surface. The color is usually bright red to dusky red. Characteristically, the lesion is asymptomatic and painless. Pyogenic granuloma is usually solitary. Cutaneous pyogenic granulomas are commonly located on the head and neck, as well as fingers and toes. In the oral cavity, pyogenic granulomas are more frequent on the gingiva. The lesion tends to bleed and ulcerate even with very minor trauma which brings patients to seek medical care. Although pyogenic granulomas occur in patients of any age, they are more prevalent in children, adolescents, and pregnant women. Cutaneous pyogenic granulomas have no gender predilection whereas the oral mucosal ones have a female to male ratio of 2:1. Trauma and female sex hormones are possible etiologic factors. The diagnosis is usually clinical. Pyogenic granulomas developing during pregnancy tend to resolve on their own after delivery and usually require no treatment. Most other lesions are treated. Surgical excision with linear closure allows histologic examination of the tissue. It also has the lowest rate of recurrence and is therefore the treatment of choice.

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Herpes Simplex Virus Type-I and Pyogenic Granuloma: A Vascular Endothelial Growth Factor-Mediated Association

Cited by 13 publications

References 15 publications

Poxvirus‐induced angiogenesis after a thermal burn

Poxvirus‐induced angiogenesis after a thermal burn

Pädiatrische Dermatohistopathologie – Histologie von Dermatosen im Neugeborenen‐ und Säuglingsalter

Pyogenic Granuloma

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